| Full name: NK6 homeobox 2 | Alias Symbol: NKX6B|GTX|NKX6.1 | ||
| Type: protein-coding gene | Cytoband: 10q26.3 | ||
| Entrez ID: 84504 | HGNC ID: HGNC:19321 | Ensembl Gene: ENSG00000148826 | OMIM ID: 605955 |
| Drug and gene relationship at DGIdb | |||
Expression of NKX6-2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKX6-2 | 84504 | 235832_at | -0.0179 | 0.9571 | |
| GSE26886 | NKX6-2 | 84504 | 235832_at | 0.2062 | 0.0487 | |
| GSE45670 | NKX6-2 | 84504 | 235832_at | 0.1715 | 0.0418 | |
| GSE53622 | NKX6-2 | 84504 | 45743 | 0.0361 | 0.6469 | |
| GSE53624 | NKX6-2 | 84504 | 45743 | -0.1625 | 0.0624 | |
| GSE63941 | NKX6-2 | 84504 | 235832_at | -0.0696 | 0.6474 | |
| GSE77861 | NKX6-2 | 84504 | 235832_at | 0.0721 | 0.4888 | |
| GSE97050 | NKX6-2 | 84504 | A_33_P3264910 | -0.0001 | 0.9997 | |
| TCGA | NKX6-2 | 84504 | RNAseq | -6.0337 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NKX6-2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKX6-2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKX6-2 | 84504 | 2 | 8 | 20 | |
| GSE20123 | NKX6-2 | 84504 | 2 | 9 | 19 | |
| GSE43470 | NKX6-2 | 84504 | 0 | 9 | 34 | |
| GSE46452 | NKX6-2 | 84504 | 1 | 11 | 47 | |
| GSE47630 | NKX6-2 | 84504 | 4 | 13 | 23 | |
| GSE54993 | NKX6-2 | 84504 | 8 | 2 | 60 | |
| GSE54994 | NKX6-2 | 84504 | 1 | 9 | 43 | |
| GSE60625 | NKX6-2 | 84504 | 0 | 0 | 11 | |
| GSE74703 | NKX6-2 | 84504 | 0 | 6 | 30 | |
| GSE74704 | NKX6-2 | 84504 | 2 | 4 | 14 |
Total number of gains: 20; Total number of losses: 71; Total Number of normals: 301.
Somatic mutations of NKX6-2:
Generating mutation plots.
Highly correlated genes for NKX6-2:
Showing top 20/68 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKX6-2 | MAPKAP1 | 0.822165 | 3 | 0 | 3 |
| NKX6-2 | RNF187 | 0.799738 | 3 | 0 | 3 |
| NKX6-2 | INTS1 | 0.736186 | 3 | 0 | 3 |
| NKX6-2 | DHX37 | 0.703668 | 3 | 0 | 3 |
| NKX6-2 | TRMT61A | 0.696492 | 3 | 0 | 3 |
| NKX6-2 | CD163L1 | 0.695957 | 3 | 0 | 3 |
| NKX6-2 | TGFB1 | 0.694077 | 3 | 0 | 3 |
| NKX6-2 | LIPF | 0.690186 | 3 | 0 | 3 |
| NKX6-2 | PPP5C | 0.688505 | 4 | 0 | 4 |
| NKX6-2 | ANGPTL4 | 0.685865 | 3 | 0 | 3 |
| NKX6-2 | SMARCAL1 | 0.682831 | 3 | 0 | 3 |
| NKX6-2 | NCAPH2 | 0.681962 | 3 | 0 | 3 |
| NKX6-2 | GTPBP10 | 0.678149 | 3 | 0 | 3 |
| NKX6-2 | B4GALT2 | 0.677256 | 3 | 0 | 3 |
| NKX6-2 | MRPS18B | 0.671867 | 3 | 0 | 3 |
| NKX6-2 | CSNK1G2 | 0.668376 | 3 | 0 | 3 |
| NKX6-2 | SH3PXD2B | 0.666299 | 3 | 0 | 3 |
| NKX6-2 | CDKN2D | 0.665083 | 3 | 0 | 3 |
| NKX6-2 | EEF1D | 0.664154 | 3 | 0 | 3 |
| NKX6-2 | RAB40AL | 0.66244 | 3 | 0 | 3 |
For details and further investigation, click here
