| Full name: SHOC2 leucine rich repeat scaffold protein | Alias Symbol: KIAA0862|SOC2|SUR-8|SOC-2|SUR8 | ||
| Type: protein-coding gene | Cytoband: 10q25.2 | ||
| Entrez ID: 8036 | HGNC ID: HGNC:15454 | Ensembl Gene: ENSG00000108061 | OMIM ID: 602775 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SHOC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of SHOC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHOC2 | 8036 | 202777_at | -0.2519 | 0.4584 | |
| GSE20347 | SHOC2 | 8036 | 202777_at | -0.5506 | 0.0000 | |
| GSE23400 | SHOC2 | 8036 | 202777_at | -0.3036 | 0.0000 | |
| GSE26886 | SHOC2 | 8036 | 202777_at | -1.7024 | 0.0000 | |
| GSE29001 | SHOC2 | 8036 | 202777_at | -0.4374 | 0.0102 | |
| GSE38129 | SHOC2 | 8036 | 202777_at | -0.4989 | 0.0000 | |
| GSE45670 | SHOC2 | 8036 | 202777_at | -0.3014 | 0.0020 | |
| GSE53622 | SHOC2 | 8036 | 19559 | -0.5028 | 0.0000 | |
| GSE53624 | SHOC2 | 8036 | 19559 | -0.5832 | 0.0000 | |
| GSE63941 | SHOC2 | 8036 | 202777_at | -0.7641 | 0.0156 | |
| GSE77861 | SHOC2 | 8036 | 202777_at | -0.4149 | 0.1340 | |
| GSE97050 | SHOC2 | 8036 | A_23_P202565 | 0.0171 | 0.9410 | |
| SRP007169 | SHOC2 | 8036 | RNAseq | -1.3749 | 0.0001 | |
| SRP008496 | SHOC2 | 8036 | RNAseq | -1.1339 | 0.0000 | |
| SRP064894 | SHOC2 | 8036 | RNAseq | -0.6218 | 0.0006 | |
| SRP133303 | SHOC2 | 8036 | RNAseq | -0.0515 | 0.6471 | |
| SRP159526 | SHOC2 | 8036 | RNAseq | -0.6247 | 0.1667 | |
| SRP193095 | SHOC2 | 8036 | RNAseq | -0.5993 | 0.0000 | |
| SRP219564 | SHOC2 | 8036 | RNAseq | -0.3093 | 0.3046 | |
| TCGA | SHOC2 | 8036 | RNAseq | -0.0974 | 0.0339 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SHOC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHOC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHOC2 | 8036 | 1 | 9 | 20 | |
| GSE20123 | SHOC2 | 8036 | 1 | 8 | 21 | |
| GSE43470 | SHOC2 | 8036 | 0 | 7 | 36 | |
| GSE46452 | SHOC2 | 8036 | 0 | 11 | 48 | |
| GSE47630 | SHOC2 | 8036 | 2 | 14 | 24 | |
| GSE54993 | SHOC2 | 8036 | 8 | 0 | 62 | |
| GSE54994 | SHOC2 | 8036 | 1 | 10 | 42 | |
| GSE60625 | SHOC2 | 8036 | 0 | 0 | 11 | |
| GSE74703 | SHOC2 | 8036 | 0 | 5 | 31 | |
| GSE74704 | SHOC2 | 8036 | 1 | 4 | 15 | |
| TCGA | SHOC2 | 8036 | 4 | 29 | 63 |
Total number of gains: 18; Total number of losses: 97; Total Number of normals: 373.
Somatic mutations of SHOC2:
Generating mutation plots.
Highly correlated genes for SHOC2:
Showing top 20/306 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHOC2 | ACAT2 | 0.776917 | 3 | 0 | 3 |
| SHOC2 | SH2D1B | 0.763619 | 3 | 0 | 3 |
| SHOC2 | B3GNT8 | 0.76032 | 4 | 0 | 4 |
| SHOC2 | GCH1 | 0.709247 | 4 | 0 | 4 |
| SHOC2 | AP5M1 | 0.703804 | 3 | 0 | 3 |
| SHOC2 | TRIM24 | 0.700049 | 3 | 0 | 3 |
| SHOC2 | SUDS3 | 0.699782 | 4 | 0 | 3 |
| SHOC2 | ACTR8 | 0.695837 | 4 | 0 | 4 |
| SHOC2 | SOX21-AS1 | 0.695395 | 3 | 0 | 3 |
| SHOC2 | CCSER2 | 0.683208 | 8 | 0 | 8 |
| SHOC2 | SLC23A3 | 0.681137 | 3 | 0 | 3 |
| SHOC2 | RABGGTB | 0.678791 | 4 | 0 | 3 |
| SHOC2 | NUDT16L1 | 0.671471 | 4 | 0 | 3 |
| SHOC2 | BUD13 | 0.670812 | 4 | 0 | 3 |
| SHOC2 | UBN2 | 0.670504 | 4 | 0 | 3 |
| SHOC2 | CCDC186 | 0.668716 | 10 | 0 | 9 |
| SHOC2 | STX7 | 0.668519 | 10 | 0 | 9 |
| SHOC2 | ZNF230 | 0.667407 | 4 | 0 | 3 |
| SHOC2 | NCKAP5 | 0.660779 | 4 | 0 | 3 |
| SHOC2 | TMEM217 | 0.658111 | 5 | 0 | 5 |
For details and further investigation, click here
