| Full name: sialic acid binding Ig like lectin 11 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 114132 | HGNC ID: HGNC:15622 | Ensembl Gene: ENSG00000161640 | OMIM ID: 607157 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SIGLEC11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC11 | 114132 | 1552911_at | -0.1165 | 0.7192 | |
| GSE26886 | SIGLEC11 | 114132 | 1552911_at | 0.0914 | 0.4392 | |
| GSE45670 | SIGLEC11 | 114132 | 1552911_at | -0.0044 | 0.9764 | |
| GSE53622 | SIGLEC11 | 114132 | 102370 | 0.3358 | 0.0003 | |
| GSE53624 | SIGLEC11 | 114132 | 102370 | 0.2630 | 0.0192 | |
| GSE63941 | SIGLEC11 | 114132 | 1552911_at | 0.1222 | 0.4859 | |
| GSE77861 | SIGLEC11 | 114132 | 1552911_at | -0.1165 | 0.5099 | |
| GSE97050 | SIGLEC11 | A_21_P0011772 | -0.0978 | 0.7370 | ||
| SRP133303 | SIGLEC11 | 114132 | RNAseq | -0.0644 | 0.8037 | |
| SRP193095 | SIGLEC11 | 114132 | RNAseq | -0.3078 | 0.1846 | |
| SRP219564 | SIGLEC11 | 114132 | RNAseq | 0.0966 | 0.8830 | |
| TCGA | SIGLEC11 | 114132 | RNAseq | -3.2981 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SIGLEC11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC11 | 114132 | 4 | 4 | 22 | |
| GSE20123 | SIGLEC11 | 114132 | 4 | 3 | 23 | |
| GSE43470 | SIGLEC11 | 114132 | 5 | 11 | 27 | |
| GSE46452 | SIGLEC11 | 114132 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC11 | 114132 | 10 | 6 | 24 | |
| GSE54993 | SIGLEC11 | 114132 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC11 | 114132 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC11 | 114132 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC11 | 114132 | 5 | 7 | 24 | |
| GSE74704 | SIGLEC11 | 114132 | 4 | 1 | 15 | |
| TCGA | SIGLEC11 | 114132 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of SIGLEC11:
Generating mutation plots.
Highly correlated genes for SIGLEC11:
Showing top 20/443 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC11 | GHSR | 0.792604 | 3 | 0 | 3 |
| SIGLEC11 | KRTAP10-12 | 0.784331 | 3 | 0 | 3 |
| SIGLEC11 | ST8SIA3 | 0.781719 | 3 | 0 | 3 |
| SIGLEC11 | STRC | 0.772013 | 3 | 0 | 3 |
| SIGLEC11 | YY2 | 0.771157 | 3 | 0 | 3 |
| SIGLEC11 | PAX6 | 0.759878 | 3 | 0 | 3 |
| SIGLEC11 | ZNF763 | 0.74957 | 3 | 0 | 3 |
| SIGLEC11 | SLC26A1 | 0.74751 | 4 | 0 | 4 |
| SIGLEC11 | MRGPRG | 0.746972 | 3 | 0 | 3 |
| SIGLEC11 | CLTCL1 | 0.743573 | 3 | 0 | 3 |
| SIGLEC11 | OR2C3 | 0.740494 | 3 | 0 | 3 |
| SIGLEC11 | C9orf153 | 0.739678 | 3 | 0 | 3 |
| SIGLEC11 | LBX2 | 0.734083 | 3 | 0 | 3 |
| SIGLEC11 | DCDC1 | 0.732133 | 3 | 0 | 3 |
| SIGLEC11 | PGP | 0.731833 | 3 | 0 | 3 |
| SIGLEC11 | NLRP6 | 0.731425 | 3 | 0 | 3 |
| SIGLEC11 | OR10AD1 | 0.729841 | 3 | 0 | 3 |
| SIGLEC11 | GPR173 | 0.727588 | 3 | 0 | 3 |
| SIGLEC11 | CLDN9 | 0.724884 | 6 | 0 | 5 |
| SIGLEC11 | OR2T27 | 0.724453 | 3 | 0 | 3 |
For details and further investigation, click here
