| Full name: NLR family pyrin domain containing 6 | Alias Symbol: PYPAF5|PAN3|CLR11.4 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 171389 | HGNC ID: HGNC:22944 | Ensembl Gene: ENSG00000174885 | OMIM ID: 609650 |
| Drug and gene relationship at DGIdb | |||
Expression of NLRP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP6 | 171389 | 1552932_at | -0.2725 | 0.2158 | |
| GSE26886 | NLRP6 | 171389 | 1552932_at | 0.0202 | 0.8853 | |
| GSE45670 | NLRP6 | 171389 | 1552932_at | 0.1085 | 0.2890 | |
| GSE53622 | NLRP6 | 171389 | 26652 | -0.5310 | 0.0000 | |
| GSE53624 | NLRP6 | 171389 | 26652 | -0.8603 | 0.0000 | |
| GSE63941 | NLRP6 | 171389 | 1552932_at | 0.0603 | 0.7723 | |
| GSE77861 | NLRP6 | 171389 | 1552932_at | -0.2641 | 0.0514 | |
| GSE97050 | NLRP6 | 171389 | A_23_P311632 | -0.1750 | 0.4389 | |
| SRP219564 | NLRP6 | 171389 | RNAseq | 1.0043 | 0.2259 | |
| TCGA | NLRP6 | 171389 | RNAseq | -0.4259 | 0.3635 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLRP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP6 | 171389 | 1 | 11 | 18 | |
| GSE20123 | NLRP6 | 171389 | 1 | 12 | 17 | |
| GSE43470 | NLRP6 | 171389 | 1 | 11 | 31 | |
| GSE46452 | NLRP6 | 171389 | 7 | 8 | 44 | |
| GSE47630 | NLRP6 | 171389 | 4 | 12 | 24 | |
| GSE54993 | NLRP6 | 171389 | 3 | 2 | 65 | |
| GSE54994 | NLRP6 | 171389 | 1 | 12 | 40 | |
| GSE60625 | NLRP6 | 171389 | 0 | 0 | 11 | |
| GSE74703 | NLRP6 | 171389 | 1 | 9 | 26 | |
| GSE74704 | NLRP6 | 171389 | 0 | 8 | 12 | |
| TCGA | NLRP6 | 171389 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 123; Total Number of normals: 338.
Somatic mutations of NLRP6:
Generating mutation plots.
Highly correlated genes for NLRP6:
Showing top 20/280 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP6 | IL26 | 0.799344 | 3 | 0 | 3 |
| NLRP6 | CD300LG | 0.790736 | 3 | 0 | 3 |
| NLRP6 | DDC | 0.787978 | 3 | 0 | 3 |
| NLRP6 | ALAS2 | 0.754165 | 3 | 0 | 3 |
| NLRP6 | KCNF1 | 0.747618 | 3 | 0 | 3 |
| NLRP6 | SIGLEC11 | 0.731425 | 3 | 0 | 3 |
| NLRP6 | CTSE | 0.727947 | 3 | 0 | 3 |
| NLRP6 | TMEM101 | 0.725052 | 3 | 0 | 3 |
| NLRP6 | ARHGAP30 | 0.723215 | 3 | 0 | 3 |
| NLRP6 | KRT33A | 0.722092 | 3 | 0 | 3 |
| NLRP6 | GAS2L2 | 0.716366 | 3 | 0 | 3 |
| NLRP6 | UNC13B | 0.711338 | 3 | 0 | 3 |
| NLRP6 | SVOPL | 0.710178 | 3 | 0 | 3 |
| NLRP6 | IQCD | 0.701886 | 3 | 0 | 3 |
| NLRP6 | CLEC4G | 0.698873 | 3 | 0 | 3 |
| NLRP6 | ODF4 | 0.697288 | 4 | 0 | 3 |
| NLRP6 | GALK1 | 0.697038 | 4 | 0 | 3 |
| NLRP6 | GIPR | 0.69164 | 3 | 0 | 3 |
| NLRP6 | CCL24 | 0.690279 | 3 | 0 | 3 |
| NLRP6 | SMAGP | 0.688629 | 3 | 0 | 3 |
For details and further investigation, click here
