SIN3B

 

Full name: SIN3 transcription regulator family member B Alias Symbol: KIAA0700
Type: protein-coding gene Cytoband: 19p13.12
Entrez ID: 23309 HGNC ID: HGNC:19354 Ensembl Gene: ENSG00000127511 OMIM ID: 607777
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SIN3B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SIN3B 23309 209352_s_at 0.5358 0.3612
GSE20347 SIN3B 23309 39705_at 0.3918 0.0009
GSE23400 SIN3B 23309 209352_s_at 0.2657 0.0000
GSE26886 SIN3B 23309 39705_at 0.4565 0.0028
GSE29001 SIN3B 23309 39705_at 0.6105 0.1617
GSE38129 SIN3B 23309 39705_at 0.2314 0.0265
GSE45670 SIN3B 23309 39705_at 0.2528 0.0711
GSE53622 SIN3B 23309 149783 0.3469 0.0000
GSE53624 SIN3B 23309 149783 0.5507 0.0000
GSE63941 SIN3B 23309 39705_at -0.0408 0.9136
GSE77861 SIN3B 23309 39705_at 0.4499 0.0056
GSE97050 SIN3B 23309 A_33_P3225230 -0.0381 0.8624
SRP007169 SIN3B 23309 RNAseq 0.7017 0.0559
SRP008496 SIN3B 23309 RNAseq 0.8091 0.0009
SRP064894 SIN3B 23309 RNAseq 0.4354 0.0028
SRP133303 SIN3B 23309 RNAseq 0.0124 0.9264
SRP159526 SIN3B 23309 RNAseq 0.2374 0.5871
SRP193095 SIN3B 23309 RNAseq 0.7496 0.0000
SRP219564 SIN3B 23309 RNAseq 0.8350 0.1035
TCGA SIN3B 23309 RNAseq 0.0053 0.9073

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SIN3B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SIN3B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SIN3B 23309 4 3 23
GSE20123 SIN3B 23309 3 2 25
GSE43470 SIN3B 23309 2 6 35
GSE46452 SIN3B 23309 47 1 11
GSE47630 SIN3B 23309 4 8 28
GSE54993 SIN3B 23309 15 4 51
GSE54994 SIN3B 23309 6 14 33
GSE60625 SIN3B 23309 9 0 2
GSE74703 SIN3B 23309 2 4 30
GSE74704 SIN3B 23309 0 1 19
TCGA SIN3B 23309 17 9 70

Total number of gains: 109; Total number of losses: 52; Total Number of normals: 327.  

 

Somatic mutations of SIN3B:

 

Generating mutation plots.

 

Highly correlated genes for SIN3B:

 

Showing top 20/1035 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SIN3BZNF2840.757766303
SIN3BLGI20.741924303
SIN3BTEX100.741357303
SIN3BZBED10.740575303
SIN3BMB21D20.729817404
SIN3BSLC39A30.726025404
SIN3BWIZ0.72106512012
SIN3BIGF2R0.713621505
SIN3BDNAH140.711984403
SIN3BSTK32B0.70964403
SIN3BGATAD2B0.702518504
SIN3BISM20.698125303
SIN3BTMEM1730.697618303
SIN3BNOM10.695426303
SIN3BZNF7710.6942303
SIN3BZNF518B0.688089403
SIN3BALKBH60.687263505
SIN3BRILPL10.687046505
SIN3BSSBP40.680674504
SIN3BZBTB20.67924404

For details and further investigation, click here