| Full name: transmembrane protein 173 | Alias Symbol: FLJ38577|NET23|ERIS|MPYS|STING|MITA | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 340061 | HGNC ID: HGNC:27962 | Ensembl Gene: ENSG00000184584 | OMIM ID: 612374 |
| Drug and gene relationship at DGIdb | |||
TMEM173 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway | |
| hsa04623 | Cytosolic DNA-sensing pathway |
Expression of TMEM173:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM173 | 340061 | 224929_at | -0.0353 | 0.9518 | |
| GSE26886 | TMEM173 | 340061 | 224929_at | 0.2343 | 0.4927 | |
| GSE45670 | TMEM173 | 340061 | 224916_at | 0.7409 | 0.0031 | |
| GSE53622 | TMEM173 | 340061 | 49431 | 0.2933 | 0.0053 | |
| GSE53624 | TMEM173 | 340061 | 49431 | 0.4493 | 0.0001 | |
| GSE63941 | TMEM173 | 340061 | 224929_at | 0.4154 | 0.5380 | |
| GSE77861 | TMEM173 | 340061 | 224929_at | 0.3082 | 0.4577 | |
| GSE97050 | TMEM173 | 340061 | A_23_P61371 | 0.2230 | 0.5000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM173 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM173:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM173 | 340061 | 3 | 11 | 16 | |
| GSE20123 | TMEM173 | 340061 | 4 | 11 | 15 | |
| GSE43470 | TMEM173 | 340061 | 4 | 8 | 31 | |
| GSE46452 | TMEM173 | 340061 | 0 | 27 | 32 | |
| GSE47630 | TMEM173 | 340061 | 0 | 20 | 20 | |
| GSE54993 | TMEM173 | 340061 | 9 | 1 | 60 | |
| GSE54994 | TMEM173 | 340061 | 2 | 14 | 37 | |
| GSE60625 | TMEM173 | 340061 | 0 | 0 | 11 | |
| GSE74703 | TMEM173 | 340061 | 3 | 6 | 27 | |
| GSE74704 | TMEM173 | 340061 | 3 | 5 | 12 | |
| TCGA | TMEM173 | 340061 | 4 | 37 | 55 |
Total number of gains: 32; Total number of losses: 140; Total Number of normals: 316.
Somatic mutations of TMEM173:
Generating mutation plots.
Highly correlated genes for TMEM173:
Showing top 20/357 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM173 | SEC22C | 0.777919 | 3 | 0 | 3 |
| TMEM173 | CHST3 | 0.756676 | 3 | 0 | 3 |
| TMEM173 | TMEM107 | 0.751639 | 3 | 0 | 3 |
| TMEM173 | FLNB | 0.736881 | 3 | 0 | 3 |
| TMEM173 | SPI1 | 0.73644 | 4 | 0 | 4 |
| TMEM173 | STK32B | 0.727988 | 4 | 0 | 3 |
| TMEM173 | C19orf38 | 0.727835 | 3 | 0 | 3 |
| TMEM173 | PCGF2 | 0.725686 | 3 | 0 | 3 |
| TMEM173 | LRRC8C | 0.711911 | 3 | 0 | 3 |
| TMEM173 | POMGNT1 | 0.707257 | 3 | 0 | 3 |
| TMEM173 | TEX261 | 0.704618 | 3 | 0 | 3 |
| TMEM173 | NPFF | 0.704546 | 3 | 0 | 3 |
| TMEM173 | BTBD6 | 0.702375 | 3 | 0 | 3 |
| TMEM173 | GPI | 0.70109 | 3 | 0 | 3 |
| TMEM173 | SIN3B | 0.697618 | 3 | 0 | 3 |
| TMEM173 | LILRB2 | 0.697492 | 4 | 0 | 4 |
| TMEM173 | ATN1 | 0.696062 | 3 | 0 | 3 |
| TMEM173 | PDCD1LG2 | 0.696041 | 4 | 0 | 4 |
| TMEM173 | NIT1 | 0.694366 | 4 | 0 | 3 |
| TMEM173 | GALNT2 | 0.691559 | 4 | 0 | 3 |
For details and further investigation, click here
