| Full name: isthmin 2 | Alias Symbol: FLJ32147|TAIL1 | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 145501 | HGNC ID: HGNC:23176 | Ensembl Gene: ENSG00000100593 | OMIM ID: 612684 |
| Drug and gene relationship at DGIdb | |||
Expression of ISM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISM2 | 145501 | 228212_at | 0.1242 | 0.7178 | |
| GSE26886 | ISM2 | 145501 | 228212_at | 0.1686 | 0.1207 | |
| GSE45670 | ISM2 | 145501 | 228212_at | 0.1115 | 0.2548 | |
| GSE53622 | ISM2 | 145501 | 42173 | 0.3722 | 0.0080 | |
| GSE53624 | ISM2 | 145501 | 42173 | 0.6094 | 0.0000 | |
| GSE63941 | ISM2 | 145501 | 228212_at | 0.3306 | 0.1032 | |
| GSE77861 | ISM2 | 145501 | 228212_at | -0.0076 | 0.9479 | |
| GSE97050 | ISM2 | 145501 | A_23_P344125 | 0.0428 | 0.8454 | |
| TCGA | ISM2 | 145501 | RNAseq | 1.9126 | 0.0003 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ISM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISM2 | 145501 | 8 | 3 | 19 | |
| GSE20123 | ISM2 | 145501 | 8 | 3 | 19 | |
| GSE43470 | ISM2 | 145501 | 8 | 3 | 32 | |
| GSE46452 | ISM2 | 145501 | 16 | 3 | 40 | |
| GSE47630 | ISM2 | 145501 | 11 | 8 | 21 | |
| GSE54993 | ISM2 | 145501 | 3 | 8 | 59 | |
| GSE54994 | ISM2 | 145501 | 19 | 4 | 30 | |
| GSE60625 | ISM2 | 145501 | 0 | 2 | 9 | |
| GSE74703 | ISM2 | 145501 | 7 | 3 | 26 | |
| GSE74704 | ISM2 | 145501 | 3 | 3 | 14 | |
| TCGA | ISM2 | 145501 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of ISM2:
Generating mutation plots.
Highly correlated genes for ISM2:
Showing top 20/106 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISM2 | CRYBB2 | 0.759186 | 3 | 0 | 3 |
| ISM2 | NGF | 0.752662 | 3 | 0 | 3 |
| ISM2 | MIER2 | 0.748444 | 3 | 0 | 3 |
| ISM2 | C17orf67 | 0.746926 | 3 | 0 | 3 |
| ISM2 | IL3RA | 0.737124 | 3 | 0 | 3 |
| ISM2 | EPN1 | 0.72742 | 3 | 0 | 3 |
| ISM2 | ZNF579 | 0.719202 | 3 | 0 | 3 |
| ISM2 | MCOLN3 | 0.716265 | 3 | 0 | 3 |
| ISM2 | SLC26A5 | 0.703139 | 3 | 0 | 3 |
| ISM2 | FAM20C | 0.700545 | 3 | 0 | 3 |
| ISM2 | SIN3B | 0.698125 | 3 | 0 | 3 |
| ISM2 | CREB5 | 0.693859 | 3 | 0 | 3 |
| ISM2 | TP53AIP1 | 0.691582 | 4 | 0 | 4 |
| ISM2 | SUGP1 | 0.688575 | 3 | 0 | 3 |
| ISM2 | JUND | 0.681055 | 3 | 0 | 3 |
| ISM2 | ZNF638 | 0.679625 | 3 | 0 | 3 |
| ISM2 | ZNF546 | 0.676992 | 3 | 0 | 3 |
| ISM2 | SORBS3 | 0.675166 | 3 | 0 | 3 |
| ISM2 | SLC35E1 | 0.674636 | 3 | 0 | 3 |
| ISM2 | JOSD2 | 0.674427 | 4 | 0 | 3 |
For details and further investigation, click here
