| Full name: SIX homeobox 6 | Alias Symbol: Six9 | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 4990 | HGNC ID: HGNC:10892 | Ensembl Gene: ENSG00000184302 | OMIM ID: 606326 |
| Drug and gene relationship at DGIdb | |||
Expression of SIX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIX6 | 4990 | 207250_at | 0.0014 | 0.9965 | |
| GSE20347 | SIX6 | 4990 | 207250_at | -0.0644 | 0.3464 | |
| GSE23400 | SIX6 | 4990 | 207250_at | -0.0907 | 0.0036 | |
| GSE26886 | SIX6 | 4990 | 207250_at | 0.2310 | 0.0177 | |
| GSE29001 | SIX6 | 4990 | 207250_at | -0.0453 | 0.8276 | |
| GSE38129 | SIX6 | 4990 | 207250_at | -0.1077 | 0.1432 | |
| GSE45670 | SIX6 | 4990 | 207250_at | -0.0620 | 0.4601 | |
| GSE53622 | SIX6 | 4990 | 85166 | -0.0840 | 0.3516 | |
| GSE53624 | SIX6 | 4990 | 85166 | -0.0948 | 0.5262 | |
| GSE63941 | SIX6 | 4990 | 207250_at | -0.0094 | 0.9546 | |
| GSE77861 | SIX6 | 4990 | 207250_at | -0.1026 | 0.3050 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIX6 | 4990 | 8 | 3 | 19 | |
| GSE20123 | SIX6 | 4990 | 7 | 3 | 20 | |
| GSE43470 | SIX6 | 4990 | 8 | 2 | 33 | |
| GSE46452 | SIX6 | 4990 | 16 | 3 | 40 | |
| GSE47630 | SIX6 | 4990 | 11 | 9 | 20 | |
| GSE54993 | SIX6 | 4990 | 3 | 9 | 58 | |
| GSE54994 | SIX6 | 4990 | 19 | 4 | 30 | |
| GSE60625 | SIX6 | 4990 | 0 | 2 | 9 | |
| GSE74703 | SIX6 | 4990 | 7 | 2 | 27 | |
| GSE74704 | SIX6 | 4990 | 3 | 2 | 15 | |
| TCGA | SIX6 | 4990 | 32 | 14 | 50 |
Total number of gains: 114; Total number of losses: 53; Total Number of normals: 321.
Somatic mutations of SIX6:
Generating mutation plots.
Highly correlated genes for SIX6:
Showing top 20/1012 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIX6 | NAT2 | 0.772479 | 3 | 0 | 3 |
| SIX6 | TMEM8B | 0.744574 | 3 | 0 | 3 |
| SIX6 | TXNDC2 | 0.734591 | 3 | 0 | 3 |
| SIX6 | CKM | 0.725276 | 3 | 0 | 3 |
| SIX6 | GSC | 0.698996 | 3 | 0 | 3 |
| SIX6 | ENDOV | 0.695677 | 3 | 0 | 3 |
| SIX6 | CCDC151 | 0.692765 | 3 | 0 | 3 |
| SIX6 | SEC14L4 | 0.691019 | 5 | 0 | 5 |
| SIX6 | TTC9B | 0.689573 | 3 | 0 | 3 |
| SIX6 | PRLR | 0.688956 | 4 | 0 | 4 |
| SIX6 | CYP2D6 | 0.688495 | 5 | 0 | 5 |
| SIX6 | LUZP4 | 0.687036 | 4 | 0 | 4 |
| SIX6 | DLGAP2 | 0.68454 | 7 | 0 | 7 |
| SIX6 | KCNH4 | 0.683795 | 6 | 0 | 6 |
| SIX6 | CDHR2 | 0.68342 | 4 | 0 | 3 |
| SIX6 | SLC22A13 | 0.682155 | 5 | 0 | 5 |
| SIX6 | ARMC4 | 0.681913 | 5 | 0 | 5 |
| SIX6 | FAM153A | 0.681605 | 6 | 0 | 4 |
| SIX6 | NAPA-AS1 | 0.674195 | 3 | 0 | 3 |
| SIX6 | CAV3 | 0.672217 | 5 | 0 | 5 |
For details and further investigation, click here
