| Full name: solute carrier family 12 member 1 | Alias Symbol: NKCC2 | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 6557 | HGNC ID: HGNC:10910 | Ensembl Gene: ENSG00000074803 | OMIM ID: 600839 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC12A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC12A1 | 6557 | 1554842_at | -0.0695 | 0.8462 | |
| GSE20347 | SLC12A1 | 6557 | 220281_at | 0.0408 | 0.4164 | |
| GSE23400 | SLC12A1 | 6557 | 220281_at | -0.0106 | 0.3957 | |
| GSE26886 | SLC12A1 | 6557 | 1554842_at | -0.0636 | 0.6359 | |
| GSE29001 | SLC12A1 | 6557 | 220281_at | 0.0528 | 0.5648 | |
| GSE38129 | SLC12A1 | 6557 | 220281_at | 0.0110 | 0.8115 | |
| GSE45670 | SLC12A1 | 6557 | 1554842_at | -0.0296 | 0.8017 | |
| GSE53622 | SLC12A1 | 6557 | 25814 | 0.6745 | 0.0001 | |
| GSE53624 | SLC12A1 | 6557 | 25814 | 0.0836 | 0.5037 | |
| GSE63941 | SLC12A1 | 6557 | 1554842_at | 0.4272 | 0.0005 | |
| GSE77861 | SLC12A1 | 6557 | 1554842_at | -0.1494 | 0.1021 | |
| TCGA | SLC12A1 | 6557 | RNAseq | -0.0743 | 0.9453 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC12A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC12A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC12A1 | 6557 | 5 | 3 | 22 | |
| GSE20123 | SLC12A1 | 6557 | 5 | 3 | 22 | |
| GSE43470 | SLC12A1 | 6557 | 5 | 4 | 34 | |
| GSE46452 | SLC12A1 | 6557 | 3 | 7 | 49 | |
| GSE47630 | SLC12A1 | 6557 | 8 | 10 | 22 | |
| GSE54993 | SLC12A1 | 6557 | 4 | 6 | 60 | |
| GSE54994 | SLC12A1 | 6557 | 5 | 7 | 41 | |
| GSE60625 | SLC12A1 | 6557 | 4 | 0 | 7 | |
| GSE74703 | SLC12A1 | 6557 | 5 | 3 | 28 | |
| GSE74704 | SLC12A1 | 6557 | 2 | 3 | 15 | |
| TCGA | SLC12A1 | 6557 | 10 | 18 | 68 |
Total number of gains: 56; Total number of losses: 64; Total Number of normals: 368.
Somatic mutations of SLC12A1:
Generating mutation plots.
Highly correlated genes for SLC12A1:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC12A1 | TMEM105 | 0.699015 | 3 | 0 | 3 |
| SLC12A1 | GPHB5 | 0.682508 | 3 | 0 | 3 |
| SLC12A1 | KIF25 | 0.681815 | 3 | 0 | 3 |
| SLC12A1 | MEGF11 | 0.661625 | 4 | 0 | 4 |
| SLC12A1 | NFIA-AS2 | 0.658539 | 3 | 0 | 3 |
| SLC12A1 | AMBRA1 | 0.656665 | 3 | 0 | 3 |
| SLC12A1 | FAM171A2 | 0.647504 | 4 | 0 | 3 |
| SLC12A1 | TMEM95 | 0.647499 | 3 | 0 | 3 |
| SLC12A1 | DGCR10 | 0.646808 | 3 | 0 | 3 |
| SLC12A1 | SLC17A9 | 0.645914 | 3 | 0 | 3 |
| SLC12A1 | EPHA10 | 0.645681 | 3 | 0 | 3 |
| SLC12A1 | FOXN4 | 0.64113 | 4 | 0 | 3 |
| SLC12A1 | ZNF135 | 0.639193 | 3 | 0 | 3 |
| SLC12A1 | EPO | 0.639176 | 4 | 0 | 3 |
| SLC12A1 | B4GALNT1 | 0.636789 | 3 | 0 | 3 |
| SLC12A1 | TLR7 | 0.630338 | 3 | 0 | 3 |
| SLC12A1 | CRTAC1 | 0.627322 | 3 | 0 | 3 |
| SLC12A1 | TMEM79 | 0.623437 | 3 | 0 | 3 |
| SLC12A1 | LINC00165 | 0.621448 | 3 | 0 | 3 |
| SLC12A1 | PTGES2 | 0.617747 | 3 | 0 | 3 |
For details and further investigation, click here
