| Full name: solute carrier family 1 member 2 | Alias Symbol: GLT-1|EAAT2 | ||
| Type: protein-coding gene | Cytoband: 11p13 | ||
| Entrez ID: 6506 | HGNC ID: HGNC:10940 | Ensembl Gene: ENSG00000110436 | OMIM ID: 600300 |
| Drug and gene relationship at DGIdb | |||
SLC1A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of SLC1A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC1A2 | 6506 | 208389_s_at | -0.0470 | 0.8901 | |
| GSE20347 | SLC1A2 | 6506 | 208389_s_at | 0.0366 | 0.7104 | |
| GSE23400 | SLC1A2 | 6506 | 208389_s_at | -0.0819 | 0.0022 | |
| GSE26886 | SLC1A2 | 6506 | 208389_s_at | 0.0791 | 0.4645 | |
| GSE29001 | SLC1A2 | 6506 | 208389_s_at | 0.0247 | 0.9053 | |
| GSE38129 | SLC1A2 | 6506 | 208389_s_at | -0.1032 | 0.2516 | |
| GSE45670 | SLC1A2 | 6506 | 208389_s_at | -0.0369 | 0.6832 | |
| GSE53622 | SLC1A2 | 6506 | 122817 | -0.5864 | 0.0100 | |
| GSE53624 | SLC1A2 | 6506 | 122817 | -0.6883 | 0.0017 | |
| GSE63941 | SLC1A2 | 6506 | 225491_at | -3.2176 | 0.0000 | |
| GSE77861 | SLC1A2 | 6506 | 208389_s_at | -0.0235 | 0.7843 | |
| GSE97050 | SLC1A2 | 6506 | A_24_P350759 | 0.0292 | 0.8915 | |
| SRP007169 | SLC1A2 | 6506 | RNAseq | 3.1313 | 0.0073 | |
| SRP133303 | SLC1A2 | 6506 | RNAseq | -0.0769 | 0.6386 | |
| SRP159526 | SLC1A2 | 6506 | RNAseq | -0.3891 | 0.6037 | |
| SRP193095 | SLC1A2 | 6506 | RNAseq | -0.0134 | 0.9658 | |
| SRP219564 | SLC1A2 | 6506 | RNAseq | -0.3446 | 0.4487 | |
| TCGA | SLC1A2 | 6506 | RNAseq | -2.1426 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by SLC1A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC1A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC1A2 | 6506 | 2 | 6 | 22 | |
| GSE20123 | SLC1A2 | 6506 | 2 | 5 | 23 | |
| GSE43470 | SLC1A2 | 6506 | 3 | 4 | 36 | |
| GSE46452 | SLC1A2 | 6506 | 7 | 5 | 47 | |
| GSE47630 | SLC1A2 | 6506 | 3 | 10 | 27 | |
| GSE54993 | SLC1A2 | 6506 | 3 | 2 | 65 | |
| GSE54994 | SLC1A2 | 6506 | 3 | 10 | 40 | |
| GSE60625 | SLC1A2 | 6506 | 0 | 0 | 11 | |
| GSE74703 | SLC1A2 | 6506 | 2 | 2 | 32 | |
| GSE74704 | SLC1A2 | 6506 | 0 | 3 | 17 | |
| TCGA | SLC1A2 | 6506 | 15 | 23 | 58 |
Total number of gains: 40; Total number of losses: 70; Total Number of normals: 378.
Somatic mutations of SLC1A2:
Generating mutation plots.
Highly correlated genes for SLC1A2:
Showing top 20/388 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC1A2 | PRSS12 | 0.785651 | 3 | 0 | 3 |
| SLC1A2 | DOK6 | 0.716378 | 3 | 0 | 3 |
| SLC1A2 | ZNF836 | 0.702038 | 3 | 0 | 3 |
| SLC1A2 | ST6GALNAC6 | 0.693157 | 3 | 0 | 3 |
| SLC1A2 | DZIP1L | 0.684556 | 3 | 0 | 3 |
| SLC1A2 | FGFR1 | 0.678575 | 4 | 0 | 4 |
| SLC1A2 | MAP4 | 0.67107 | 3 | 0 | 3 |
| SLC1A2 | LMAN1 | 0.66654 | 3 | 0 | 3 |
| SLC1A2 | NEURL1 | 0.662206 | 6 | 0 | 5 |
| SLC1A2 | PSG1 | 0.661175 | 5 | 0 | 5 |
| SLC1A2 | ZNF829 | 0.655394 | 3 | 0 | 3 |
| SLC1A2 | NPHS2 | 0.643069 | 5 | 0 | 5 |
| SLC1A2 | ZNF358 | 0.641417 | 3 | 0 | 3 |
| SLC1A2 | RASGEF1B | 0.639505 | 3 | 0 | 3 |
| SLC1A2 | TMEM170B | 0.638581 | 3 | 0 | 3 |
| SLC1A2 | MAP1A | 0.636562 | 4 | 0 | 3 |
| SLC1A2 | COLEC10 | 0.63638 | 7 | 0 | 6 |
| SLC1A2 | TRIML1 | 0.636155 | 3 | 0 | 3 |
| SLC1A2 | AFF3 | 0.6344 | 3 | 0 | 3 |
| SLC1A2 | C1orf68 | 0.633318 | 4 | 0 | 4 |
For details and further investigation, click here
