| Full name: RasGEF domain family member 1B | Alias Symbol: GPIG4|FLJ31695 | ||
| Type: protein-coding gene | Cytoband: 4q21.21 | ||
| Entrez ID: 153020 | HGNC ID: HGNC:24881 | Ensembl Gene: ENSG00000138670 | OMIM ID: 614532 |
| Drug and gene relationship at DGIdb | |||
Expression of RASGEF1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGEF1B | 153020 | 1554999_at | -0.8328 | 0.1902 | |
| GSE26886 | RASGEF1B | 153020 | 1554999_at | -2.8731 | 0.0001 | |
| GSE45670 | RASGEF1B | 153020 | 1553785_at | -0.3744 | 0.1143 | |
| GSE53622 | RASGEF1B | 153020 | 78695 | -0.7095 | 0.0000 | |
| GSE53624 | RASGEF1B | 153020 | 78695 | -0.8911 | 0.0000 | |
| GSE63941 | RASGEF1B | 153020 | 1554999_at | 0.0091 | 0.9624 | |
| GSE77861 | RASGEF1B | 153020 | 1554999_at | -0.4049 | 0.1472 | |
| GSE97050 | RASGEF1B | 153020 | A_33_P3364646 | -0.2030 | 0.5713 | |
| SRP007169 | RASGEF1B | 153020 | RNAseq | -3.4387 | 0.0000 | |
| SRP008496 | RASGEF1B | 153020 | RNAseq | -3.1816 | 0.0000 | |
| SRP064894 | RASGEF1B | 153020 | RNAseq | -1.9486 | 0.0000 | |
| SRP133303 | RASGEF1B | 153020 | RNAseq | -1.1733 | 0.0000 | |
| SRP159526 | RASGEF1B | 153020 | RNAseq | 0.0187 | 0.9774 | |
| SRP193095 | RASGEF1B | 153020 | RNAseq | -2.0873 | 0.0000 | |
| SRP219564 | RASGEF1B | 153020 | RNAseq | -1.2597 | 0.0275 | |
| TCGA | RASGEF1B | 153020 | RNAseq | 0.0465 | 0.7200 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by RASGEF1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGEF1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGEF1B | 153020 | 1 | 10 | 19 | |
| GSE20123 | RASGEF1B | 153020 | 1 | 10 | 19 | |
| GSE43470 | RASGEF1B | 153020 | 0 | 13 | 30 | |
| GSE46452 | RASGEF1B | 153020 | 1 | 36 | 22 | |
| GSE47630 | RASGEF1B | 153020 | 1 | 19 | 20 | |
| GSE54993 | RASGEF1B | 153020 | 8 | 0 | 62 | |
| GSE54994 | RASGEF1B | 153020 | 0 | 9 | 44 | |
| GSE60625 | RASGEF1B | 153020 | 0 | 0 | 11 | |
| GSE74703 | RASGEF1B | 153020 | 0 | 11 | 25 | |
| GSE74704 | RASGEF1B | 153020 | 1 | 5 | 14 | |
| TCGA | RASGEF1B | 153020 | 12 | 35 | 49 |
Total number of gains: 25; Total number of losses: 148; Total Number of normals: 315.
Somatic mutations of RASGEF1B:
Generating mutation plots.
Highly correlated genes for RASGEF1B:
Showing top 20/840 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGEF1B | CCNYL1 | 0.749948 | 3 | 0 | 3 |
| RASGEF1B | ZNF143 | 0.748792 | 3 | 0 | 3 |
| RASGEF1B | PADI1 | 0.745301 | 3 | 0 | 3 |
| RASGEF1B | SESN2 | 0.734051 | 7 | 0 | 7 |
| RASGEF1B | NPAS2 | 0.731343 | 3 | 0 | 3 |
| RASGEF1B | HDHD2 | 0.729975 | 4 | 0 | 3 |
| RASGEF1B | GBA2 | 0.726957 | 3 | 0 | 3 |
| RASGEF1B | GADD45A | 0.723043 | 3 | 0 | 3 |
| RASGEF1B | CLDND1 | 0.722023 | 3 | 0 | 3 |
| RASGEF1B | RBM20 | 0.721449 | 4 | 0 | 4 |
| RASGEF1B | SRR | 0.719963 | 3 | 0 | 3 |
| RASGEF1B | LPIN1 | 0.719349 | 6 | 0 | 6 |
| RASGEF1B | PDLIM2 | 0.715016 | 4 | 0 | 4 |
| RASGEF1B | APIP | 0.712481 | 3 | 0 | 3 |
| RASGEF1B | ACAA2 | 0.711939 | 3 | 0 | 3 |
| RASGEF1B | CLK3 | 0.710309 | 3 | 0 | 3 |
| RASGEF1B | ST6GALNAC6 | 0.706044 | 4 | 0 | 3 |
| RASGEF1B | FAM122C | 0.705396 | 4 | 0 | 3 |
| RASGEF1B | SNAPC3 | 0.70353 | 4 | 0 | 3 |
| RASGEF1B | TRIM3 | 0.699744 | 3 | 0 | 3 |
For details and further investigation, click here
