| Full name: serine protease 12 | Alias Symbol: BSSP-3|MRT1 | ||
| Type: protein-coding gene | Cytoband: 4q26 | ||
| Entrez ID: 8492 | HGNC ID: HGNC:9477 | Ensembl Gene: ENSG00000164099 | OMIM ID: 606709 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS12 | 8492 | 213802_at | 0.5046 | 0.6464 | |
| GSE20347 | PRSS12 | 8492 | 213802_at | 0.0697 | 0.6628 | |
| GSE23400 | PRSS12 | 8492 | 205515_at | 0.0718 | 0.1113 | |
| GSE26886 | PRSS12 | 8492 | 213802_at | 0.6124 | 0.1557 | |
| GSE29001 | PRSS12 | 8492 | 205515_at | 0.0257 | 0.9190 | |
| GSE38129 | PRSS12 | 8492 | 213802_at | -0.0573 | 0.6983 | |
| GSE45670 | PRSS12 | 8492 | 213802_at | 0.4099 | 0.3518 | |
| GSE53622 | PRSS12 | 8492 | 93281 | -0.4256 | 0.0348 | |
| GSE53624 | PRSS12 | 8492 | 93281 | -0.5150 | 0.0017 | |
| GSE63941 | PRSS12 | 8492 | 213802_at | -3.4703 | 0.0015 | |
| GSE77861 | PRSS12 | 8492 | 213802_at | 0.1728 | 0.6493 | |
| GSE97050 | PRSS12 | 8492 | A_23_P121637 | 0.1358 | 0.7856 | |
| SRP007169 | PRSS12 | 8492 | RNAseq | -0.3710 | 0.5867 | |
| SRP064894 | PRSS12 | 8492 | RNAseq | -0.1282 | 0.7649 | |
| SRP133303 | PRSS12 | 8492 | RNAseq | 0.2164 | 0.5402 | |
| SRP159526 | PRSS12 | 8492 | RNAseq | 0.5220 | 0.3212 | |
| SRP193095 | PRSS12 | 8492 | RNAseq | 0.0083 | 0.9734 | |
| SRP219564 | PRSS12 | 8492 | RNAseq | 0.0806 | 0.8823 | |
| TCGA | PRSS12 | 8492 | RNAseq | -0.0490 | 0.8646 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PRSS12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRSS12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS12 | 8492 | 0 | 13 | 17 | |
| GSE20123 | PRSS12 | 8492 | 1 | 13 | 16 | |
| GSE43470 | PRSS12 | 8492 | 0 | 13 | 30 | |
| GSE46452 | PRSS12 | 8492 | 1 | 36 | 22 | |
| GSE47630 | PRSS12 | 8492 | 0 | 22 | 18 | |
| GSE54993 | PRSS12 | 8492 | 9 | 0 | 61 | |
| GSE54994 | PRSS12 | 8492 | 1 | 10 | 42 | |
| GSE60625 | PRSS12 | 8492 | 0 | 1 | 10 | |
| GSE74703 | PRSS12 | 8492 | 0 | 11 | 25 | |
| GSE74704 | PRSS12 | 8492 | 0 | 7 | 13 | |
| TCGA | PRSS12 | 8492 | 9 | 34 | 53 |
Total number of gains: 21; Total number of losses: 160; Total Number of normals: 307.
Somatic mutations of PRSS12:
Generating mutation plots.
Highly correlated genes for PRSS12:
Showing top 20/159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS12 | SLC1A2 | 0.785651 | 3 | 0 | 3 |
| PRSS12 | CCDC7 | 0.715813 | 3 | 0 | 3 |
| PRSS12 | NPFFR1 | 0.710384 | 3 | 0 | 3 |
| PRSS12 | LDLRAD3 | 0.699821 | 3 | 0 | 3 |
| PRSS12 | ZNF467 | 0.694416 | 3 | 0 | 3 |
| PRSS12 | COPB1 | 0.692984 | 3 | 0 | 3 |
| PRSS12 | AKR1C1 | 0.682073 | 3 | 0 | 3 |
| PRSS12 | ACSL4 | 0.681964 | 3 | 0 | 3 |
| PRSS12 | PSTPIP2 | 0.680276 | 3 | 0 | 3 |
| PRSS12 | PTPRA | 0.679711 | 3 | 0 | 3 |
| PRSS12 | SEL1L3 | 0.677202 | 4 | 0 | 3 |
| PRSS12 | SH2B3 | 0.67655 | 3 | 0 | 3 |
| PRSS12 | ZNF804A | 0.67551 | 3 | 0 | 3 |
| PRSS12 | TUSC3 | 0.670215 | 3 | 0 | 3 |
| PRSS12 | C12orf49 | 0.668671 | 4 | 0 | 3 |
| PRSS12 | AFP | 0.666261 | 3 | 0 | 3 |
| PRSS12 | CRYBA1 | 0.655218 | 4 | 0 | 4 |
| PRSS12 | AEBP2 | 0.655081 | 3 | 0 | 3 |
| PRSS12 | ARHGAP24 | 0.654802 | 4 | 0 | 4 |
| PRSS12 | ZCCHC3 | 0.648483 | 3 | 0 | 3 |
For details and further investigation, click here
