ACVR2A

 

Full name: activin A receptor type 2A Alias Symbol: ACTRII
Type: protein-coding gene Cytoband: 2q22.3-q23.1
Entrez ID: 92 HGNC ID: HGNC:173 Ensembl Gene: ENSG00000121989 OMIM ID: 102581
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 26/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ACVR2A involved pathways:

KEGG pathway Description View
hsa04350TGF-beta signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells

 

Expression of ACVR2A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ACVR2A 92 205327_s_at -0.3133 0.5161
GSE20347 ACVR2A 92 205327_s_at -0.4095 0.0085
GSE23400 ACVR2A 92 205327_s_at -0.0272 0.6382
GSE26886 ACVR2A 92 205327_s_at -0.6212 0.0074
GSE29001 ACVR2A 92 205327_s_at -0.5755 0.0214
GSE38129 ACVR2A 92 205327_s_at -0.3249 0.0209
GSE45670 ACVR2A 92 205327_s_at -0.2283 0.2479
GSE53622 ACVR2A 92 115431 -0.3690 0.0006
GSE53624 ACVR2A 92 115431 -0.5342 0.0000
GSE63941 ACVR2A 92 205327_s_at -0.7151 0.2277
GSE77861 ACVR2A 92 205327_s_at -0.0731 0.6046
GSE97050 ACVR2A 92 A_23_P153930 -0.1714 0.4438
SRP007169 ACVR2A 92 RNAseq -0.7124 0.1620
SRP008496 ACVR2A 92 RNAseq -0.4693 0.1175
SRP064894 ACVR2A 92 RNAseq -0.4565 0.0189
SRP133303 ACVR2A 92 RNAseq -0.4207 0.1152
SRP159526 ACVR2A 92 RNAseq 0.2973 0.6031
SRP193095 ACVR2A 92 RNAseq -0.9904 0.0000
SRP219564 ACVR2A 92 RNAseq -0.7285 0.1176
TCGA ACVR2A 92 RNAseq -0.2647 0.0002

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ACVR2A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ACVR2A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ACVR2A 92 4 2 24
GSE20123 ACVR2A 92 4 2 24
GSE43470 ACVR2A 92 3 1 39
GSE46452 ACVR2A 92 1 4 54
GSE47630 ACVR2A 92 5 3 32
GSE54993 ACVR2A 92 0 6 64
GSE54994 ACVR2A 92 11 2 40
GSE60625 ACVR2A 92 0 3 8
GSE74703 ACVR2A 92 2 1 33
GSE74704 ACVR2A 92 3 1 16
TCGA ACVR2A 92 22 10 64

Total number of gains: 55; Total number of losses: 35; Total Number of normals: 398.  

 

Somatic mutations of ACVR2A:

 

Generating mutation plots.

 

Highly correlated genes for ACVR2A:

 

Showing top 20/666 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ACVR2AKIAA20260.787703303
ACVR2ANIPSNAP3A0.783727303
ACVR2AZCCHC100.766067303
ACVR2AZNF240.764762404
ACVR2ACOG30.743659303
ACVR2AUSP380.738258303
ACVR2ANAA350.736997403
ACVR2AIFT740.735147404
ACVR2AIMPA10.725287303
ACVR2AGORASP10.721488403
ACVR2ATBC1D230.717953303
ACVR2ACOX6B10.713684303
ACVR2AMED280.711453303
ACVR2AEAF10.706053303
ACVR2ALARP1B0.706008303
ACVR2AITPRIPL20.705704303
ACVR2AZDHHC210.702734303
ACVR2ASMARCA20.702729303
ACVR2ABRK10.700703303
ACVR2APITPNM30.697479303

For details and further investigation, click here