| Full name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 | Alias Symbol: DEP.2|FLJ12987|P-REX2|PPP1R129 | ||
| Type: protein-coding gene | Cytoband: 8q13.2 | ||
| Entrez ID: 80243 | HGNC ID: HGNC:22950 | Ensembl Gene: ENSG00000046889 | OMIM ID: 612139 |
| Drug and gene relationship at DGIdb | |||
Expression of PREX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PREX2 | 80243 | 228692_at | -0.9044 | 0.0902 | |
| GSE20347 | PREX2 | 80243 | 220732_at | 0.0260 | 0.6864 | |
| GSE23400 | PREX2 | 80243 | 220732_at | -0.1250 | 0.0010 | |
| GSE26886 | PREX2 | 80243 | 233408_at | -0.0471 | 0.6950 | |
| GSE29001 | PREX2 | 80243 | 220732_at | -0.1141 | 0.4257 | |
| GSE38129 | PREX2 | 80243 | 220732_at | -0.0461 | 0.4591 | |
| GSE45670 | PREX2 | 80243 | 220732_at | 0.0734 | 0.3209 | |
| GSE53622 | PREX2 | 80243 | 17234 | -1.0627 | 0.0000 | |
| GSE53624 | PREX2 | 80243 | 17234 | -0.9420 | 0.0000 | |
| GSE63941 | PREX2 | 80243 | 220732_at | -0.0180 | 0.9115 | |
| GSE77861 | PREX2 | 80243 | 233408_at | -0.0402 | 0.6782 | |
| GSE97050 | PREX2 | 80243 | A_33_P3394995 | -0.4135 | 0.1702 | |
| SRP007169 | PREX2 | 80243 | RNAseq | 0.8749 | 0.1746 | |
| SRP064894 | PREX2 | 80243 | RNAseq | 0.0794 | 0.8455 | |
| SRP133303 | PREX2 | 80243 | RNAseq | -0.9571 | 0.0003 | |
| SRP159526 | PREX2 | 80243 | RNAseq | -0.3804 | 0.4010 | |
| SRP193095 | PREX2 | 80243 | RNAseq | 0.0475 | 0.8039 | |
| SRP219564 | PREX2 | 80243 | RNAseq | -0.2609 | 0.6830 | |
| TCGA | PREX2 | 80243 | RNAseq | -1.3402 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PREX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PREX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PREX2 | 80243 | 15 | 1 | 14 | |
| GSE20123 | PREX2 | 80243 | 16 | 1 | 13 | |
| GSE43470 | PREX2 | 80243 | 16 | 3 | 24 | |
| GSE46452 | PREX2 | 80243 | 20 | 2 | 37 | |
| GSE47630 | PREX2 | 80243 | 23 | 1 | 16 | |
| GSE54993 | PREX2 | 80243 | 1 | 18 | 51 | |
| GSE54994 | PREX2 | 80243 | 30 | 0 | 23 | |
| GSE60625 | PREX2 | 80243 | 0 | 4 | 7 | |
| GSE74703 | PREX2 | 80243 | 14 | 2 | 20 | |
| GSE74704 | PREX2 | 80243 | 11 | 0 | 9 | |
| TCGA | PREX2 | 80243 | 50 | 4 | 42 |
Total number of gains: 196; Total number of losses: 36; Total Number of normals: 256.
Somatic mutations of PREX2:
Generating mutation plots.
Highly correlated genes for PREX2:
Showing top 20/1075 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PREX2 | EBF1 | 0.852257 | 4 | 0 | 4 |
| PREX2 | CYYR1 | 0.846301 | 4 | 0 | 4 |
| PREX2 | JAM2 | 0.84395 | 4 | 0 | 4 |
| PREX2 | AOC3 | 0.832674 | 4 | 0 | 4 |
| PREX2 | TMEM100 | 0.829913 | 3 | 0 | 3 |
| PREX2 | MAGI2-AS3 | 0.822398 | 3 | 0 | 3 |
| PREX2 | CSDE1 | 0.822058 | 3 | 0 | 3 |
| PREX2 | JAM3 | 0.81825 | 4 | 0 | 4 |
| PREX2 | FNBP1 | 0.816418 | 3 | 0 | 3 |
| PREX2 | RCAN2 | 0.815362 | 4 | 0 | 4 |
| PREX2 | COL14A1 | 0.813671 | 4 | 0 | 4 |
| PREX2 | LRRN4CL | 0.813426 | 4 | 0 | 4 |
| PREX2 | SMIM10 | 0.812896 | 3 | 0 | 3 |
| PREX2 | UBXN10 | 0.812674 | 3 | 0 | 3 |
| PREX2 | FHL1 | 0.811643 | 4 | 0 | 4 |
| PREX2 | TCEAL6 | 0.801528 | 3 | 0 | 3 |
| PREX2 | TGFBR3 | 0.79737 | 4 | 0 | 4 |
| PREX2 | ECSCR | 0.79723 | 4 | 0 | 4 |
| PREX2 | PLN | 0.796302 | 4 | 0 | 4 |
| PREX2 | RHOJ | 0.795707 | 5 | 0 | 4 |
For details and further investigation, click here
