| Full name: sorting nexin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q23.2 | ||
| Entrez ID: 6643 | HGNC ID: HGNC:11173 | Ensembl Gene: ENSG00000205302 | OMIM ID: 605929 |
| Drug and gene relationship at DGIdb | |||
Expression of SNX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SNX2 | 6643 | 202113_s_at | -0.7372 | 0.1572 | |
| GSE20347 | SNX2 | 6643 | 202113_s_at | -0.8923 | 0.0001 | |
| GSE23400 | SNX2 | 6643 | 202113_s_at | -0.4588 | 0.0000 | |
| GSE26886 | SNX2 | 6643 | 202114_at | -0.1655 | 0.3858 | |
| GSE29001 | SNX2 | 6643 | 202114_at | -0.5449 | 0.0195 | |
| GSE38129 | SNX2 | 6643 | 202113_s_at | -0.6071 | 0.0021 | |
| GSE45670 | SNX2 | 6643 | 202113_s_at | -0.4503 | 0.0066 | |
| GSE53622 | SNX2 | 6643 | 76647 | -0.6617 | 0.0000 | |
| GSE53624 | SNX2 | 6643 | 76647 | -0.4974 | 0.0000 | |
| GSE63941 | SNX2 | 6643 | 202113_s_at | 0.4538 | 0.1745 | |
| GSE77861 | SNX2 | 6643 | 202113_s_at | -0.7980 | 0.0299 | |
| GSE97050 | SNX2 | 6643 | A_23_P7697 | -0.6493 | 0.1556 | |
| SRP007169 | SNX2 | 6643 | RNAseq | -1.3958 | 0.0001 | |
| SRP008496 | SNX2 | 6643 | RNAseq | -1.2319 | 0.0000 | |
| SRP064894 | SNX2 | 6643 | RNAseq | -0.4504 | 0.0009 | |
| SRP133303 | SNX2 | 6643 | RNAseq | -0.2273 | 0.1784 | |
| SRP159526 | SNX2 | 6643 | RNAseq | -0.5226 | 0.1849 | |
| SRP193095 | SNX2 | 6643 | RNAseq | -0.7604 | 0.0000 | |
| SRP219564 | SNX2 | 6643 | RNAseq | -0.6010 | 0.1005 | |
| TCGA | SNX2 | 6643 | RNAseq | -0.1710 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SNX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SNX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SNX2 | 6643 | 1 | 13 | 16 | |
| GSE20123 | SNX2 | 6643 | 1 | 13 | 16 | |
| GSE43470 | SNX2 | 6643 | 3 | 8 | 32 | |
| GSE46452 | SNX2 | 6643 | 0 | 27 | 32 | |
| GSE47630 | SNX2 | 6643 | 0 | 21 | 19 | |
| GSE54993 | SNX2 | 6643 | 9 | 1 | 60 | |
| GSE54994 | SNX2 | 6643 | 2 | 14 | 37 | |
| GSE60625 | SNX2 | 6643 | 0 | 0 | 11 | |
| GSE74703 | SNX2 | 6643 | 2 | 6 | 28 | |
| GSE74704 | SNX2 | 6643 | 1 | 7 | 12 | |
| TCGA | SNX2 | 6643 | 3 | 41 | 52 |
Total number of gains: 22; Total number of losses: 151; Total Number of normals: 315.
Somatic mutations of SNX2:
Generating mutation plots.
Highly correlated genes for SNX2:
Showing top 20/788 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SNX2 | CYP21A2 | 0.739346 | 3 | 0 | 3 |
| SNX2 | STARD9 | 0.736624 | 3 | 0 | 3 |
| SNX2 | CLEC3B | 0.729994 | 3 | 0 | 3 |
| SNX2 | ANKRD37 | 0.722042 | 3 | 0 | 3 |
| SNX2 | SKP1 | 0.721838 | 10 | 0 | 9 |
| SNX2 | ZNF383 | 0.705918 | 3 | 0 | 3 |
| SNX2 | APC | 0.703169 | 9 | 0 | 8 |
| SNX2 | PLEKHB1 | 0.701265 | 3 | 0 | 3 |
| SNX2 | ZNF585A | 0.69959 | 3 | 0 | 3 |
| SNX2 | CCNG1 | 0.699451 | 10 | 0 | 10 |
| SNX2 | ZCCHC9 | 0.693137 | 5 | 0 | 5 |
| SNX2 | IK | 0.69116 | 12 | 0 | 11 |
| SNX2 | INTS6-AS1 | 0.678994 | 3 | 0 | 3 |
| SNX2 | SLC43A3 | 0.674068 | 3 | 0 | 3 |
| SNX2 | EMC3 | 0.672466 | 8 | 0 | 6 |
| SNX2 | NDUFS4 | 0.671225 | 11 | 0 | 10 |
| SNX2 | RAP1A | 0.669447 | 10 | 0 | 9 |
| SNX2 | DMXL1 | 0.668688 | 12 | 0 | 12 |
| SNX2 | UFSP2 | 0.66798 | 10 | 0 | 8 |
| SNX2 | PCP4L1 | 0.667212 | 4 | 0 | 3 |
For details and further investigation, click here
