APC

 

Full name: APC regulator of WNT signaling pathway Alias Symbol: DP2|DP3|DP2.5|PPP1R46
Type: protein-coding gene Cytoband: 5q22.2
Entrez ID: 324 HGNC ID: HGNC:583 Ensembl Gene: ENSG00000134982 OMIM ID: 611731
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 36/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

APC involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04810Regulation of actin cytoskeleton
hsa05166HTLV-I infection
hsa05213Endometrial cancer

 

Expression of APC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 APC 324 203525_s_at -0.8203 0.0870
GSE20347 APC 324 203525_s_at -0.9654 0.0000
GSE23400 APC 324 203527_s_at -0.1402 0.0000
GSE26886 APC 324 203525_s_at -0.2473 0.3726
GSE29001 APC 324 203525_s_at -0.6503 0.0601
GSE38129 APC 324 203525_s_at -0.7811 0.0000
GSE45670 APC 324 203525_s_at -0.2606 0.0460
GSE53622 APC 324 1890 -0.4400 0.0000
GSE53624 APC 324 1890 -0.2517 0.0024
GSE63941 APC 324 203525_s_at -0.9833 0.0880
GSE77861 APC 324 203525_s_at -0.8045 0.0233
GSE97050 APC 324 A_33_P3408983 -0.1696 0.5367
SRP007169 APC 324 RNAseq -0.3121 0.3463
SRP008496 APC 324 RNAseq -0.3603 0.0829
SRP064894 APC 324 RNAseq -0.7505 0.0007
SRP133303 APC 324 RNAseq -0.1834 0.2244
SRP159526 APC 324 RNAseq -0.6480 0.1101
SRP193095 APC 324 RNAseq -0.6077 0.0000
SRP219564 APC 324 RNAseq -0.8555 0.0103
TCGA APC 324 RNAseq -0.0796 0.1641

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by APC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of APC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 APC 324 1 13 16
GSE20123 APC 324 1 13 16
GSE43470 APC 324 3 8 32
GSE46452 APC 324 0 28 31
GSE47630 APC 324 0 21 19
GSE54993 APC 324 9 1 60
GSE54994 APC 324 1 17 35
GSE60625 APC 324 0 0 11
GSE74703 APC 324 2 6 28
GSE74704 APC 324 1 7 12
TCGA APC 324 3 41 52

Total number of gains: 21; Total number of losses: 155; Total Number of normals: 312.  

 

Somatic mutations of APC:

 

Generating mutation plots.

 

Highly correlated genes for APC:

 

Showing top 20/1025 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
APCBCAP290.772653505
APCC16orf720.76742303
APCCLTB0.757965505
APCTRIM60.741475303
APCPTGR10.732702303
APCDMXL10.72949710010
APCUGP20.718404706
APCCD590.713004606
APCDHX290.712393908
APCDLD0.709172504
APCSNX20.703169908
APCTTC370.7028041009
APCANKRD370.701237303
APCTHRB0.696805403
APCALAS10.695378505
APCIQGAP10.695224403
APCGOLGA40.694683908
APCWDR410.690337605
APCHIGD1A0.688675807
APCCHMP2B0.686497909

For details and further investigation, click here