| Full name: S-phase kinase associated protein 1 | Alias Symbol: EMC19|OCP2|TCEB1L|MGC34403|OCP-II|p19A | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 6500 | HGNC ID: HGNC:10899 | Ensembl Gene: ENSG00000113558 | OMIM ID: 601434 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SKP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04350 | TGF-beta signaling pathway | |
| hsa04710 | Circadian rhythm |
Expression of SKP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SKP1 | 6500 | 200718_s_at | -0.3466 | 0.1410 | |
| GSE20347 | SKP1 | 6500 | 200718_s_at | -0.4018 | 0.0189 | |
| GSE23400 | SKP1 | 6500 | 200718_s_at | -0.2336 | 0.0001 | |
| GSE26886 | SKP1 | 6500 | 200718_s_at | -0.1434 | 0.3896 | |
| GSE29001 | SKP1 | 6500 | 200718_s_at | -0.4042 | 0.2916 | |
| GSE38129 | SKP1 | 6500 | 200718_s_at | -0.3587 | 0.0079 | |
| GSE45670 | SKP1 | 6500 | 200718_s_at | -0.2149 | 0.0170 | |
| GSE53622 | SKP1 | 6500 | 85928 | -0.5967 | 0.0000 | |
| GSE53624 | SKP1 | 6500 | 85928 | -0.4268 | 0.0000 | |
| GSE63941 | SKP1 | 6500 | 200718_s_at | -0.5491 | 0.0187 | |
| GSE77861 | SKP1 | 6500 | 200718_s_at | -0.5614 | 0.0590 | |
| GSE97050 | SKP1 | 6500 | A_23_P133424 | -0.6784 | 0.0965 | |
| SRP007169 | SKP1 | 6500 | RNAseq | -1.6253 | 0.0000 | |
| SRP008496 | SKP1 | 6500 | RNAseq | -1.4277 | 0.0000 | |
| SRP064894 | SKP1 | 6500 | RNAseq | -0.6166 | 0.0001 | |
| SRP133303 | SKP1 | 6500 | RNAseq | -0.1036 | 0.5851 | |
| SRP159526 | SKP1 | 6500 | RNAseq | -0.0587 | 0.8743 | |
| SRP193095 | SKP1 | 6500 | RNAseq | -0.7054 | 0.0000 | |
| SRP219564 | SKP1 | 6500 | RNAseq | -0.5742 | 0.1927 | |
| TCGA | SKP1 | 6500 | RNAseq | -0.0409 | 0.3293 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SKP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SKP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SKP1 | 6500 | 2 | 11 | 17 | |
| GSE20123 | SKP1 | 6500 | 3 | 11 | 16 | |
| GSE43470 | SKP1 | 6500 | 2 | 8 | 33 | |
| GSE46452 | SKP1 | 6500 | 0 | 27 | 32 | |
| GSE47630 | SKP1 | 6500 | 0 | 21 | 19 | |
| GSE54993 | SKP1 | 6500 | 9 | 1 | 60 | |
| GSE54994 | SKP1 | 6500 | 2 | 14 | 37 | |
| GSE60625 | SKP1 | 6500 | 0 | 0 | 11 | |
| GSE74703 | SKP1 | 6500 | 2 | 5 | 29 | |
| GSE74704 | SKP1 | 6500 | 2 | 5 | 13 | |
| TCGA | SKP1 | 6500 | 3 | 37 | 56 |
Total number of gains: 25; Total number of losses: 140; Total Number of normals: 323.
Somatic mutations of SKP1:
Generating mutation plots.
Highly correlated genes for SKP1:
Showing top 20/1096 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SKP1 | PIGP | 0.747346 | 4 | 0 | 4 |
| SKP1 | IK | 0.734706 | 10 | 0 | 9 |
| SKP1 | PCP4L1 | 0.734285 | 3 | 0 | 3 |
| SKP1 | CLMP | 0.724708 | 3 | 0 | 3 |
| SKP1 | GNPDA2 | 0.722595 | 3 | 0 | 3 |
| SKP1 | EVC2 | 0.72208 | 3 | 0 | 3 |
| SKP1 | LEPROT | 0.721987 | 4 | 0 | 4 |
| SKP1 | SNX2 | 0.721838 | 10 | 0 | 9 |
| SKP1 | AFF4 | 0.717921 | 8 | 0 | 8 |
| SKP1 | HINT3 | 0.717508 | 4 | 0 | 4 |
| SKP1 | NKAPL | 0.717261 | 5 | 0 | 5 |
| SKP1 | BAD | 0.716375 | 3 | 0 | 3 |
| SKP1 | UBE2Q2 | 0.705346 | 3 | 0 | 3 |
| SKP1 | C11orf96 | 0.692463 | 3 | 0 | 3 |
| SKP1 | MTMR3 | 0.692222 | 4 | 0 | 3 |
| SKP1 | EBF1 | 0.691428 | 4 | 0 | 4 |
| SKP1 | HMHB1 | 0.687643 | 3 | 0 | 3 |
| SKP1 | ARRDC3 | 0.687633 | 6 | 0 | 5 |
| SKP1 | POLR2L | 0.685317 | 5 | 0 | 5 |
| SKP1 | EIF4E3 | 0.684908 | 7 | 0 | 7 |
For details and further investigation, click here
