| Full name: RAP1A, member of RAS oncogene family | Alias Symbol: KREV-1|SMGP21 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 5906 | HGNC ID: HGNC:9855 | Ensembl Gene: ENSG00000116473 | OMIM ID: 179520 |
| Drug and gene relationship at DGIdb | |||
RAP1A involved pathways:
Expression of RAP1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAP1A | 5906 | 202362_at | -1.0720 | 0.0265 | |
| GSE20347 | RAP1A | 5906 | 202362_at | -1.1144 | 0.0000 | |
| GSE23400 | RAP1A | 5906 | 202362_at | -0.6074 | 0.0000 | |
| GSE26886 | RAP1A | 5906 | 202362_at | -1.1254 | 0.0000 | |
| GSE29001 | RAP1A | 5906 | 202362_at | -0.7325 | 0.0043 | |
| GSE38129 | RAP1A | 5906 | 202362_at | -1.2105 | 0.0000 | |
| GSE45670 | RAP1A | 5906 | 202362_at | -0.9545 | 0.0000 | |
| GSE53622 | RAP1A | 5906 | 42477 | -0.9558 | 0.0000 | |
| GSE53624 | RAP1A | 5906 | 42477 | -0.8210 | 0.0000 | |
| GSE63941 | RAP1A | 5906 | 202362_at | -0.3256 | 0.5340 | |
| GSE77861 | RAP1A | 5906 | 202362_at | -1.0884 | 0.0003 | |
| GSE97050 | RAP1A | 5906 | A_33_P3342285 | -0.9151 | 0.0940 | |
| SRP007169 | RAP1A | 5906 | RNAseq | -1.1229 | 0.0009 | |
| SRP008496 | RAP1A | 5906 | RNAseq | -0.9289 | 0.0000 | |
| SRP064894 | RAP1A | 5906 | RNAseq | -0.5950 | 0.0003 | |
| SRP133303 | RAP1A | 5906 | RNAseq | -0.1959 | 0.4310 | |
| SRP159526 | RAP1A | 5906 | RNAseq | -1.0346 | 0.0000 | |
| SRP193095 | RAP1A | 5906 | RNAseq | -0.7367 | 0.0000 | |
| SRP219564 | RAP1A | 5906 | RNAseq | -0.9106 | 0.1461 | |
| TCGA | RAP1A | 5906 | RNAseq | -0.2544 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by RAP1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAP1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAP1A | 5906 | 0 | 10 | 20 | |
| GSE20123 | RAP1A | 5906 | 0 | 10 | 20 | |
| GSE43470 | RAP1A | 5906 | 0 | 8 | 35 | |
| GSE46452 | RAP1A | 5906 | 2 | 1 | 56 | |
| GSE47630 | RAP1A | 5906 | 9 | 5 | 26 | |
| GSE54993 | RAP1A | 5906 | 0 | 1 | 69 | |
| GSE54994 | RAP1A | 5906 | 7 | 4 | 42 | |
| GSE60625 | RAP1A | 5906 | 0 | 0 | 11 | |
| GSE74703 | RAP1A | 5906 | 0 | 7 | 29 | |
| GSE74704 | RAP1A | 5906 | 0 | 6 | 14 | |
| TCGA | RAP1A | 5906 | 7 | 27 | 62 |
Total number of gains: 25; Total number of losses: 79; Total Number of normals: 384.
Somatic mutations of RAP1A:
Generating mutation plots.
Highly correlated genes for RAP1A:
Showing top 20/1937 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAP1A | SLMAP | 0.833081 | 7 | 0 | 7 |
| RAP1A | PRICKLE2 | 0.793631 | 6 | 0 | 6 |
| RAP1A | NEGR1 | 0.791845 | 5 | 0 | 5 |
| RAP1A | MRVI1 | 0.787899 | 5 | 0 | 5 |
| RAP1A | ASB5 | 0.785444 | 5 | 0 | 5 |
| RAP1A | HIGD1A | 0.783566 | 11 | 0 | 11 |
| RAP1A | KAT2B | 0.782525 | 11 | 0 | 11 |
| RAP1A | LMBRD1 | 0.781909 | 11 | 0 | 11 |
| RAP1A | CITED2 | 0.778535 | 11 | 0 | 11 |
| RAP1A | NFIA | 0.776757 | 7 | 0 | 7 |
| RAP1A | NDUFV3 | 0.774953 | 3 | 0 | 3 |
| RAP1A | FYCO1 | 0.773193 | 11 | 0 | 11 |
| RAP1A | CLEC3B | 0.772271 | 3 | 0 | 3 |
| RAP1A | CALCOCO2 | 0.772164 | 11 | 0 | 11 |
| RAP1A | GFRA1 | 0.771378 | 5 | 0 | 5 |
| RAP1A | PREX2 | 0.770418 | 4 | 0 | 4 |
| RAP1A | TMEM132C | 0.769801 | 3 | 0 | 3 |
| RAP1A | FCHO2 | 0.767953 | 7 | 0 | 7 |
| RAP1A | SNORA68 | 0.766968 | 4 | 0 | 4 |
| RAP1A | ADAMTS9-AS2 | 0.764157 | 4 | 0 | 4 |
For details and further investigation, click here
