| Full name: ER membrane protein complex subunit 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 55831 | HGNC ID: HGNC:23999 | Ensembl Gene: ENSG00000125037 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EMC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EMC3 | 55831 | 217882_at | -0.4569 | 0.1942 | |
| GSE20347 | EMC3 | 55831 | 217882_at | -1.1505 | 0.0000 | |
| GSE23400 | EMC3 | 55831 | 217882_at | -0.8575 | 0.0000 | |
| GSE26886 | EMC3 | 55831 | 217882_at | -1.2290 | 0.0000 | |
| GSE29001 | EMC3 | 55831 | 217882_at | -1.3552 | 0.0012 | |
| GSE38129 | EMC3 | 55831 | 217882_at | -0.8920 | 0.0000 | |
| GSE45670 | EMC3 | 55831 | 217882_at | -0.4620 | 0.0134 | |
| GSE53622 | EMC3 | 55831 | 32062 | -1.0776 | 0.0000 | |
| GSE53624 | EMC3 | 55831 | 32062 | -1.3423 | 0.0000 | |
| GSE63941 | EMC3 | 55831 | 217882_at | -0.6905 | 0.1102 | |
| GSE77861 | EMC3 | 55831 | 217882_at | -0.8798 | 0.0042 | |
| SRP007169 | EMC3 | 55831 | RNAseq | -2.2908 | 0.0000 | |
| SRP008496 | EMC3 | 55831 | RNAseq | -2.2195 | 0.0000 | |
| SRP064894 | EMC3 | 55831 | RNAseq | -1.1362 | 0.0000 | |
| SRP133303 | EMC3 | 55831 | RNAseq | -0.8406 | 0.0000 | |
| SRP159526 | EMC3 | 55831 | RNAseq | -1.2018 | 0.0000 | |
| SRP193095 | EMC3 | 55831 | RNAseq | -1.1617 | 0.0000 | |
| SRP219564 | EMC3 | 55831 | RNAseq | -1.3922 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by EMC3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of EMC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EMC3 | 55831 | 1 | 18 | 11 | |
| GSE20123 | EMC3 | 55831 | 1 | 18 | 11 | |
| GSE43470 | EMC3 | 55831 | 1 | 20 | 22 | |
| GSE46452 | EMC3 | 55831 | 2 | 17 | 40 | |
| GSE47630 | EMC3 | 55831 | 2 | 23 | 15 | |
| GSE54993 | EMC3 | 55831 | 6 | 1 | 63 | |
| GSE54994 | EMC3 | 55831 | 3 | 31 | 19 | |
| GSE60625 | EMC3 | 55831 | 5 | 0 | 6 | |
| GSE74703 | EMC3 | 55831 | 1 | 16 | 19 | |
| GSE74704 | EMC3 | 55831 | 1 | 11 | 8 | |
| TCGA | EMC3 | 55831 | 5 | 65 | 26 |
Total number of gains: 28; Total number of losses: 220; Total Number of normals: 240.
Somatic mutations of EMC3:
Generating mutation plots.
Highly correlated genes for EMC3:
Showing top 20/1646 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EMC3 | SERPINB1 | 0.803168 | 10 | 0 | 10 |
| EMC3 | CAPN14 | 0.802352 | 6 | 0 | 6 |
| EMC3 | ZNF185 | 0.800528 | 10 | 0 | 10 |
| EMC3 | HIGD1A | 0.800459 | 10 | 0 | 10 |
| EMC3 | RANBP9 | 0.798633 | 10 | 0 | 10 |
| EMC3 | CXCR2 | 0.796772 | 10 | 0 | 10 |
| EMC3 | TMOD3 | 0.793922 | 10 | 0 | 10 |
| EMC3 | UBL3 | 0.791046 | 11 | 0 | 11 |
| EMC3 | PRSS27 | 0.790476 | 6 | 0 | 6 |
| EMC3 | BNIPL | 0.789089 | 6 | 0 | 6 |
| EMC3 | KAT2B | 0.788211 | 11 | 0 | 11 |
| EMC3 | GDPD3 | 0.785975 | 10 | 0 | 10 |
| EMC3 | RAB11A | 0.785803 | 10 | 0 | 10 |
| EMC3 | RNF141 | 0.783789 | 10 | 0 | 10 |
| EMC3 | MRPS36 | 0.783241 | 6 | 0 | 6 |
| EMC3 | ABHD5 | 0.78075 | 11 | 0 | 10 |
| EMC3 | PDCD6IP | 0.780635 | 10 | 0 | 10 |
| EMC3 | ACPP | 0.780062 | 10 | 0 | 10 |
| EMC3 | CYSRT1 | 0.780005 | 6 | 0 | 6 |
| EMC3 | ENDOU | 0.779832 | 10 | 0 | 10 |
For details and further investigation, click here
