| Full name: SRY-box transcription factor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 6656 | HGNC ID: HGNC:11189 | Ensembl Gene: ENSG00000182968 | OMIM ID: 602148 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX1 | 6656 | 230982_at | 0.0630 | 0.8981 | |
| GSE20347 | SOX1 | 6656 | 208533_at | 0.0382 | 0.5971 | |
| GSE23400 | SOX1 | 6656 | 208533_at | -0.0459 | 0.0244 | |
| GSE26886 | SOX1 | 6656 | 230982_at | 0.3017 | 0.0649 | |
| GSE29001 | SOX1 | 6656 | 208533_at | 0.0122 | 0.9432 | |
| GSE38129 | SOX1 | 6656 | 208533_at | -0.0199 | 0.7714 | |
| GSE45670 | SOX1 | 6656 | 208533_at | -0.1138 | 0.3438 | |
| GSE63941 | SOX1 | 6656 | 230982_at | 0.3814 | 0.0338 | |
| GSE77861 | SOX1 | 6656 | 230982_at | -0.0140 | 0.9341 | |
| TCGA | SOX1 | 6656 | RNAseq | 2.8113 | 0.0025 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SOX1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX1 | 6656 | 6 | 12 | 12 | |
| GSE20123 | SOX1 | 6656 | 6 | 11 | 13 | |
| GSE43470 | SOX1 | 6656 | 4 | 13 | 26 | |
| GSE46452 | SOX1 | 6656 | 3 | 31 | 25 | |
| GSE47630 | SOX1 | 6656 | 3 | 26 | 11 | |
| GSE54993 | SOX1 | 6656 | 11 | 4 | 55 | |
| GSE54994 | SOX1 | 6656 | 9 | 8 | 36 | |
| GSE60625 | SOX1 | 6656 | 0 | 3 | 8 | |
| GSE74703 | SOX1 | 6656 | 3 | 9 | 24 | |
| GSE74704 | SOX1 | 6656 | 4 | 9 | 7 | |
| TCGA | SOX1 | 6656 | 20 | 33 | 43 |
Total number of gains: 69; Total number of losses: 159; Total Number of normals: 260.
Somatic mutations of SOX1:
Generating mutation plots.
Highly correlated genes for SOX1:
Showing top 20/254 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX1 | NKX1-1 | 0.75119 | 3 | 0 | 3 |
| SOX1 | ROPN1L | 0.694914 | 3 | 0 | 3 |
| SOX1 | PYY | 0.685624 | 4 | 0 | 3 |
| SOX1 | AK8 | 0.662855 | 3 | 0 | 3 |
| SOX1 | TTLL6 | 0.640866 | 3 | 0 | 3 |
| SOX1 | VPS9D1-AS1 | 0.628883 | 5 | 0 | 4 |
| SOX1 | AGRP | 0.628397 | 4 | 0 | 4 |
| SOX1 | SPIN2A | 0.627724 | 4 | 0 | 4 |
| SOX1 | SCGB2B2 | 0.626712 | 4 | 0 | 3 |
| SOX1 | ZSCAN10 | 0.623895 | 4 | 0 | 3 |
| SOX1 | ARMC6 | 0.622243 | 3 | 0 | 3 |
| SOX1 | B3GALT1 | 0.620531 | 4 | 0 | 3 |
| SOX1 | WNT10B | 0.618174 | 4 | 0 | 4 |
| SOX1 | KLF15 | 0.612067 | 3 | 0 | 3 |
| SOX1 | ART1 | 0.60539 | 5 | 0 | 4 |
| SOX1 | FRMD5 | 0.603518 | 3 | 0 | 3 |
| SOX1 | RENBP | 0.602901 | 4 | 0 | 3 |
| SOX1 | SLC8A3 | 0.602437 | 4 | 0 | 3 |
| SOX1 | SEC14L3 | 0.599874 | 3 | 0 | 3 |
| SOX1 | SLC6A12 | 0.599829 | 4 | 0 | 3 |
For details and further investigation, click here
