| Full name: NK1 homeobox 1 | Alias Symbol: HSPX153|SAX2 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 54729 | HGNC ID: HGNC:24975 | Ensembl Gene: ENSG00000235608 | OMIM ID: 617869 |
| Drug and gene relationship at DGIdb | |||
Expression of NKX1-1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKX1-1 | 54729 | 1565537_at | 0.0224 | 0.9436 | |
| GSE26886 | NKX1-1 | 54729 | 1565537_at | 0.3304 | 0.0385 | |
| GSE45670 | NKX1-1 | 54729 | 1565537_at | 0.2144 | 0.0673 | |
| GSE63941 | NKX1-1 | 54729 | 1565537_at | 0.3612 | 0.0688 | |
| GSE77861 | NKX1-1 | 54729 | 1565537_at | -0.0827 | 0.6549 |
Upregulated datasets: 0; Downregulated datasets: 0.
Copy number change of NKX1-1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKX1-1 | 54729 | 0 | 16 | 14 | |
| GSE20123 | NKX1-1 | 54729 | 0 | 16 | 14 | |
| GSE43470 | NKX1-1 | 54729 | 0 | 17 | 26 | |
| GSE46452 | NKX1-1 | 54729 | 1 | 36 | 22 | |
| GSE47630 | NKX1-1 | 54729 | 2 | 19 | 19 | |
| GSE54993 | NKX1-1 | 54729 | 11 | 0 | 59 | |
| GSE54994 | NKX1-1 | 54729 | 3 | 12 | 38 | |
| GSE60625 | NKX1-1 | 54729 | 0 | 0 | 11 | |
| GSE74703 | NKX1-1 | 54729 | 0 | 13 | 23 | |
| GSE74704 | NKX1-1 | 54729 | 0 | 8 | 12 |
Total number of gains: 17; Total number of losses: 137; Total Number of normals: 238.
Somatic mutations of NKX1-1:
Generating mutation plots.
Highly correlated genes for NKX1-1:
Showing top 20/57 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKX1-1 | SOX1 | 0.75119 | 3 | 0 | 3 |
| NKX1-1 | DOC2A | 0.68668 | 3 | 0 | 3 |
| NKX1-1 | TP53TG5 | 0.661321 | 3 | 0 | 3 |
| NKX1-1 | HOTTIP | 0.652923 | 4 | 0 | 4 |
| NKX1-1 | TGIF2LY | 0.640308 | 3 | 0 | 3 |
| NKX1-1 | DLL4 | 0.638608 | 3 | 0 | 3 |
| NKX1-1 | ATCAY | 0.621712 | 3 | 0 | 3 |
| NKX1-1 | AATK | 0.621392 | 3 | 0 | 3 |
| NKX1-1 | PRAMEF11 | 0.616985 | 3 | 0 | 3 |
| NKX1-1 | SLC8A3 | 0.616694 | 4 | 0 | 3 |
| NKX1-1 | GLRA2 | 0.613795 | 4 | 0 | 4 |
| NKX1-1 | CLCA1 | 0.61173 | 3 | 0 | 3 |
| NKX1-1 | CABP4 | 0.611645 | 4 | 0 | 4 |
| NKX1-1 | RGMB-AS1 | 0.609823 | 4 | 0 | 3 |
| NKX1-1 | EXTL1 | 0.592857 | 3 | 0 | 3 |
| NKX1-1 | VPS9D1-AS1 | 0.589541 | 4 | 0 | 3 |
| NKX1-1 | PTGIR | 0.587284 | 3 | 0 | 3 |
| NKX1-1 | HOXC-AS3 | 0.585697 | 3 | 0 | 3 |
| NKX1-1 | PANX2 | 0.584115 | 4 | 0 | 3 |
| NKX1-1 | FNDC8 | 0.583396 | 4 | 0 | 3 |
For details and further investigation, click here
