| Full name: solute carrier family 8 member A3 | Alias Symbol: NCX3 | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 6547 | HGNC ID: HGNC:11070 | Ensembl Gene: ENSG00000100678 | OMIM ID: 607991 |
| Drug and gene relationship at DGIdb | |||
SLC8A3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway |
Expression of SLC8A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC8A3 | 6547 | 1568859_a_at | 0.0263 | 0.9424 | |
| GSE26886 | SLC8A3 | 6547 | 1568859_a_at | 0.4263 | 0.0014 | |
| GSE45670 | SLC8A3 | 6547 | 1568859_a_at | 0.0704 | 0.3820 | |
| GSE53622 | SLC8A3 | 6547 | 97211 | -0.6251 | 0.0000 | |
| GSE53624 | SLC8A3 | 6547 | 97211 | -0.8497 | 0.0000 | |
| GSE63941 | SLC8A3 | 6547 | 1568859_a_at | 0.2321 | 0.1525 | |
| GSE77861 | SLC8A3 | 6547 | 1568859_a_at | 0.0316 | 0.7973 | |
| GSE97050 | SLC8A3 | 6547 | A_24_P167654 | 0.1159 | 0.5846 | |
| SRP133303 | SLC8A3 | 6547 | RNAseq | -1.8503 | 0.0000 | |
| TCGA | SLC8A3 | 6547 | RNAseq | -1.9732 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SLC8A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC8A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC8A3 | 6547 | 8 | 3 | 19 | |
| GSE20123 | SLC8A3 | 6547 | 8 | 3 | 19 | |
| GSE43470 | SLC8A3 | 6547 | 8 | 3 | 32 | |
| GSE46452 | SLC8A3 | 6547 | 16 | 3 | 40 | |
| GSE47630 | SLC8A3 | 6547 | 11 | 9 | 20 | |
| GSE54993 | SLC8A3 | 6547 | 3 | 9 | 58 | |
| GSE54994 | SLC8A3 | 6547 | 18 | 5 | 30 | |
| GSE60625 | SLC8A3 | 6547 | 0 | 2 | 9 | |
| GSE74703 | SLC8A3 | 6547 | 7 | 3 | 26 | |
| GSE74704 | SLC8A3 | 6547 | 3 | 3 | 14 | |
| TCGA | SLC8A3 | 6547 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of SLC8A3:
Generating mutation plots.
Highly correlated genes for SLC8A3:
Showing top 20/208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC8A3 | CHGA | 0.74959 | 3 | 0 | 3 |
| SLC8A3 | CALCA | 0.743653 | 3 | 0 | 3 |
| SLC8A3 | DNAJC22 | 0.740469 | 3 | 0 | 3 |
| SLC8A3 | TMEM59L | 0.740045 | 3 | 0 | 3 |
| SLC8A3 | CCL27 | 0.724951 | 3 | 0 | 3 |
| SLC8A3 | PNPLA2 | 0.711884 | 5 | 0 | 5 |
| SLC8A3 | LAIR2 | 0.708878 | 4 | 0 | 4 |
| SLC8A3 | RIMBP2 | 0.706113 | 3 | 0 | 3 |
| SLC8A3 | CORT | 0.698972 | 3 | 0 | 3 |
| SLC8A3 | ROPN1L | 0.693701 | 4 | 0 | 3 |
| SLC8A3 | PHOSPHO1 | 0.692679 | 3 | 0 | 3 |
| SLC8A3 | C6orf15 | 0.692242 | 4 | 0 | 4 |
| SLC8A3 | THPO | 0.68121 | 3 | 0 | 3 |
| SLC8A3 | DNAJC5B | 0.678453 | 3 | 0 | 3 |
| SLC8A3 | KIR2DS1 | 0.67443 | 3 | 0 | 3 |
| SLC8A3 | USHBP1 | 0.673486 | 3 | 0 | 3 |
| SLC8A3 | FURIN | 0.670363 | 3 | 0 | 3 |
| SLC8A3 | GP9 | 0.667591 | 4 | 0 | 4 |
| SLC8A3 | TREM1 | 0.666452 | 3 | 0 | 3 |
| SLC8A3 | HNF1B | 0.664863 | 4 | 0 | 4 |
For details and further investigation, click here
