| Full name: speedy/RINGO cell cycle regulator family member E2 | Alias Symbol: MGC119295 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 441273 | HGNC ID: HGNC:33841 | Ensembl Gene: ENSG00000205238 | OMIM ID: 617624 |
| Drug and gene relationship at DGIdb | |||
SPDYE2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of SPDYE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPDYE2 | 441273 | 217610_at | 0.6848 | 0.3393 | |
| GSE20347 | SPDYE2 | 441273 | 217610_at | 0.4111 | 0.0735 | |
| GSE23400 | SPDYE2 | 441273 | 217610_at | 0.2755 | 0.0125 | |
| GSE26886 | SPDYE2 | 441273 | 217610_at | 0.1094 | 0.4104 | |
| GSE29001 | SPDYE2 | 441273 | 217610_at | 0.2461 | 0.3336 | |
| GSE38129 | SPDYE2 | 441273 | 217610_at | 0.3948 | 0.0393 | |
| GSE45670 | SPDYE2 | 441273 | 217610_at | 0.6487 | 0.0062 | |
| GSE63941 | SPDYE2 | 441273 | 217610_at | -0.0999 | 0.8015 | |
| GSE77861 | SPDYE2 | 441273 | 217610_at | 0.2516 | 0.1882 | |
| GSE97050 | SPDYE2 | 441273 | A_33_P3249524 | 0.1502 | 0.5019 | |
| SRP133303 | SPDYE2 | 441273 | RNAseq | 0.4776 | 0.1514 | |
| SRP159526 | SPDYE2 | 441273 | RNAseq | 0.7841 | 0.0644 | |
| SRP193095 | SPDYE2 | 441273 | RNAseq | 0.7140 | 0.0051 | |
| SRP219564 | SPDYE2 | 441273 | RNAseq | 0.8080 | 0.4606 | |
| TCGA | SPDYE2 | 441273 | RNAseq | 0.4451 | 0.2507 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPDYE2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SPDYE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDYE2 | 441273 | 13 | 0 | 17 | |
| GSE20123 | SPDYE2 | 441273 | 12 | 0 | 18 | |
| GSE43470 | SPDYE2 | 441273 | 6 | 3 | 34 | |
| GSE46452 | SPDYE2 | 441273 | 10 | 1 | 48 | |
| GSE47630 | SPDYE2 | 441273 | 7 | 3 | 30 | |
| GSE54993 | SPDYE2 | 441273 | 1 | 10 | 59 | |
| GSE54994 | SPDYE2 | 441273 | 15 | 3 | 35 | |
| GSE60625 | SPDYE2 | 441273 | 0 | 0 | 11 | |
| GSE74703 | SPDYE2 | 441273 | 6 | 2 | 28 | |
| GSE74704 | SPDYE2 | 441273 | 9 | 0 | 11 | |
| TCGA | SPDYE2 | 441273 | 53 | 6 | 37 |
Total number of gains: 132; Total number of losses: 28; Total Number of normals: 328.
Somatic mutations of SPDYE2:
Generating mutation plots.
Highly correlated genes for SPDYE2:
Showing top 20/173 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDYE2 | TAPT1-AS1 | 0.779386 | 3 | 0 | 3 |
| SPDYE2 | FUT8-AS1 | 0.713497 | 3 | 0 | 3 |
| SPDYE2 | ARHGEF1 | 0.706146 | 4 | 0 | 4 |
| SPDYE2 | CMTM4 | 0.702681 | 3 | 0 | 3 |
| SPDYE2 | SLC26A6 | 0.690687 | 3 | 0 | 3 |
| SPDYE2 | CMBL | 0.684866 | 4 | 0 | 3 |
| SPDYE2 | UBXN2A | 0.682896 | 5 | 0 | 5 |
| SPDYE2 | CHD7 | 0.682574 | 3 | 0 | 3 |
| SPDYE2 | POU3F4 | 0.681846 | 3 | 0 | 3 |
| SPDYE2 | TNRC6C-AS1 | 0.670813 | 4 | 0 | 4 |
| SPDYE2 | WDPCP | 0.647627 | 4 | 0 | 3 |
| SPDYE2 | AAK1 | 0.64529 | 6 | 0 | 5 |
| SPDYE2 | DBT | 0.644222 | 7 | 0 | 5 |
| SPDYE2 | LRRC69 | 0.642947 | 3 | 0 | 3 |
| SPDYE2 | MMP14 | 0.642317 | 3 | 0 | 3 |
| SPDYE2 | FASTKD3 | 0.637971 | 3 | 0 | 3 |
| SPDYE2 | ANKRD10-IT1 | 0.631438 | 7 | 0 | 6 |
| SPDYE2 | CCDC152 | 0.628576 | 5 | 0 | 4 |
| SPDYE2 | NLN | 0.627437 | 6 | 0 | 4 |
| SPDYE2 | RAD9A | 0.624817 | 7 | 0 | 6 |
For details and further investigation, click here
