| Full name: AP2 associated kinase 1 | Alias Symbol: KIAA1048|DKFZp686K16132 | ||
| Type: protein-coding gene | Cytoband: 2p13.3 | ||
| Entrez ID: 22848 | HGNC ID: HGNC:19679 | Ensembl Gene: ENSG00000115977 | OMIM ID: 616405 |
| Drug and gene relationship at DGIdb | |||
Expression of AAK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AAK1 | 22848 | 205434_s_at | 0.4810 | 0.3190 | |
| GSE20347 | AAK1 | 22848 | 205434_s_at | 0.4787 | 0.0012 | |
| GSE23400 | AAK1 | 22848 | 205434_s_at | 0.1733 | 0.0112 | |
| GSE26886 | AAK1 | 22848 | 225522_at | 0.3145 | 0.1083 | |
| GSE29001 | AAK1 | 22848 | 205434_s_at | 0.2802 | 0.5388 | |
| GSE38129 | AAK1 | 22848 | 205434_s_at | 0.3374 | 0.0074 | |
| GSE45670 | AAK1 | 22848 | 205434_s_at | 0.7019 | 0.0000 | |
| GSE53622 | AAK1 | 22848 | 25643 | 0.2346 | 0.0000 | |
| GSE53624 | AAK1 | 22848 | 25643 | 0.1103 | 0.0399 | |
| GSE63941 | AAK1 | 22848 | 225522_at | -0.6530 | 0.1184 | |
| GSE77861 | AAK1 | 22848 | 205434_s_at | 0.6084 | 0.0103 | |
| GSE97050 | AAK1 | 22848 | A_33_P3289204 | 0.2515 | 0.2641 | |
| SRP007169 | AAK1 | 22848 | RNAseq | 1.0369 | 0.0176 | |
| SRP008496 | AAK1 | 22848 | RNAseq | 0.8461 | 0.0009 | |
| SRP064894 | AAK1 | 22848 | RNAseq | 0.3476 | 0.0015 | |
| SRP133303 | AAK1 | 22848 | RNAseq | 0.3603 | 0.0090 | |
| SRP159526 | AAK1 | 22848 | RNAseq | 0.3731 | 0.1145 | |
| SRP193095 | AAK1 | 22848 | RNAseq | 0.2234 | 0.0161 | |
| SRP219564 | AAK1 | 22848 | RNAseq | 0.0036 | 0.9875 | |
| TCGA | AAK1 | 22848 | RNAseq | -0.1700 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AAK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AAK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AAK1 | 22848 | 11 | 0 | 19 | |
| GSE20123 | AAK1 | 22848 | 11 | 0 | 19 | |
| GSE43470 | AAK1 | 22848 | 3 | 0 | 40 | |
| GSE46452 | AAK1 | 22848 | 2 | 3 | 54 | |
| GSE47630 | AAK1 | 22848 | 7 | 0 | 33 | |
| GSE54993 | AAK1 | 22848 | 0 | 6 | 64 | |
| GSE54994 | AAK1 | 22848 | 12 | 0 | 41 | |
| GSE60625 | AAK1 | 22848 | 0 | 3 | 8 | |
| GSE74703 | AAK1 | 22848 | 3 | 0 | 33 | |
| GSE74704 | AAK1 | 22848 | 9 | 0 | 11 | |
| TCGA | AAK1 | 22848 | 37 | 3 | 56 |
Total number of gains: 95; Total number of losses: 15; Total Number of normals: 378.
Somatic mutations of AAK1:
Generating mutation plots.
Highly correlated genes for AAK1:
Showing top 20/739 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AAK1 | ARF1 | 0.799359 | 3 | 0 | 3 |
| AAK1 | SLC39A3 | 0.791697 | 3 | 0 | 3 |
| AAK1 | CBX1 | 0.789259 | 3 | 0 | 3 |
| AAK1 | ELOF1 | 0.786659 | 3 | 0 | 3 |
| AAK1 | SPIRE2 | 0.770531 | 3 | 0 | 3 |
| AAK1 | RFX1 | 0.762046 | 3 | 0 | 3 |
| AAK1 | CRYBB2 | 0.737085 | 3 | 0 | 3 |
| AAK1 | SPNS1 | 0.732667 | 3 | 0 | 3 |
| AAK1 | TOR1A | 0.732054 | 3 | 0 | 3 |
| AAK1 | MADD | 0.726169 | 3 | 0 | 3 |
| AAK1 | IFRD2 | 0.722425 | 3 | 0 | 3 |
| AAK1 | THAP5 | 0.721346 | 3 | 0 | 3 |
| AAK1 | PIGG | 0.720172 | 3 | 0 | 3 |
| AAK1 | ZBED1 | 0.719206 | 4 | 0 | 4 |
| AAK1 | ARHGEF2 | 0.718704 | 4 | 0 | 4 |
| AAK1 | ANAPC4 | 0.717554 | 3 | 0 | 3 |
| AAK1 | FAM193A | 0.715159 | 4 | 0 | 3 |
| AAK1 | PIF1 | 0.713274 | 3 | 0 | 3 |
| AAK1 | GTPBP1 | 0.708256 | 4 | 0 | 4 |
| AAK1 | TRAF3IP1 | 0.706417 | 4 | 0 | 4 |
For details and further investigation, click here
