| Full name: matrix metallopeptidase 14 | Alias Symbol: MT1-MMP | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 4323 | HGNC ID: HGNC:7160 | Ensembl Gene: ENSG00000157227 | OMIM ID: 600754 |
| Drug and gene relationship at DGIdb | |||
MMP14 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04912 | GnRH signaling pathway |
Expression of MMP14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP14 | 4323 | 160020_at | 0.7767 | 0.1175 | |
| GSE20347 | MMP14 | 4323 | 202828_s_at | 0.1941 | 0.0202 | |
| GSE23400 | MMP14 | 4323 | 160020_at | 0.4671 | 0.0000 | |
| GSE26886 | MMP14 | 4323 | 217279_x_at | -0.4448 | 0.0021 | |
| GSE29001 | MMP14 | 4323 | 160020_at | 0.1076 | 0.4692 | |
| GSE38129 | MMP14 | 4323 | 160020_at | 0.6251 | 0.0085 | |
| GSE45670 | MMP14 | 4323 | 160020_at | 0.6977 | 0.0001 | |
| GSE53622 | MMP14 | 4323 | 1173 | 1.3253 | 0.0000 | |
| GSE53624 | MMP14 | 4323 | 1173 | 0.8696 | 0.0000 | |
| GSE63941 | MMP14 | 4323 | 160020_at | -1.3964 | 0.0226 | |
| GSE77861 | MMP14 | 4323 | 160020_at | 0.3488 | 0.0811 | |
| GSE97050 | MMP14 | 4323 | A_24_P82106 | 0.3025 | 0.4079 | |
| SRP007169 | MMP14 | 4323 | RNAseq | 1.3098 | 0.0005 | |
| SRP008496 | MMP14 | 4323 | RNAseq | 1.5844 | 0.0000 | |
| SRP064894 | MMP14 | 4323 | RNAseq | 2.3169 | 0.0000 | |
| SRP133303 | MMP14 | 4323 | RNAseq | 2.2049 | 0.0000 | |
| SRP159526 | MMP14 | 4323 | RNAseq | 1.1511 | 0.0000 | |
| SRP193095 | MMP14 | 4323 | RNAseq | 1.8312 | 0.0000 | |
| SRP219564 | MMP14 | 4323 | RNAseq | 1.7327 | 0.0001 | |
| TCGA | MMP14 | 4323 | RNAseq | 0.4511 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by MMP14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP14 | 4323 | 9 | 2 | 19 | |
| GSE20123 | MMP14 | 4323 | 9 | 2 | 19 | |
| GSE43470 | MMP14 | 4323 | 7 | 2 | 34 | |
| GSE46452 | MMP14 | 4323 | 17 | 2 | 40 | |
| GSE47630 | MMP14 | 4323 | 11 | 10 | 19 | |
| GSE54993 | MMP14 | 4323 | 3 | 11 | 56 | |
| GSE54994 | MMP14 | 4323 | 18 | 5 | 30 | |
| GSE60625 | MMP14 | 4323 | 0 | 2 | 9 | |
| GSE74703 | MMP14 | 4323 | 6 | 2 | 28 | |
| GSE74704 | MMP14 | 4323 | 4 | 1 | 15 | |
| TCGA | MMP14 | 4323 | 26 | 16 | 54 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of MMP14:
Generating mutation plots.
Highly correlated genes for MMP14:
Showing top 20/387 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP14 | STK32B | 0.750473 | 4 | 0 | 4 |
| MMP14 | NUTF2 | 0.728582 | 7 | 0 | 7 |
| MMP14 | ZBTB9 | 0.723325 | 3 | 0 | 3 |
| MMP14 | ISOC2 | 0.719568 | 3 | 0 | 3 |
| MMP14 | IL36G | 0.71665 | 3 | 0 | 3 |
| MMP14 | IFFO1 | 0.699143 | 3 | 0 | 3 |
| MMP14 | POLR1C | 0.690402 | 3 | 0 | 3 |
| MMP14 | IFFO2 | 0.689069 | 3 | 0 | 3 |
| MMP14 | TMEM173 | 0.67999 | 3 | 0 | 3 |
| MMP14 | RARRES1 | 0.678679 | 3 | 0 | 3 |
| MMP14 | RAB12 | 0.677368 | 4 | 0 | 4 |
| MMP14 | TNFRSF1A | 0.674337 | 6 | 0 | 6 |
| MMP14 | LINC00460 | 0.673734 | 5 | 0 | 5 |
| MMP14 | SURF4 | 0.672789 | 4 | 0 | 4 |
| MMP14 | TMEM107 | 0.670319 | 3 | 0 | 3 |
| MMP14 | RAB11FIP5 | 0.668961 | 5 | 0 | 4 |
| MMP14 | NIPAL4 | 0.66813 | 3 | 0 | 3 |
| MMP14 | C6orf141 | 0.667633 | 5 | 0 | 4 |
| MMP14 | GMPPA | 0.666265 | 4 | 0 | 4 |
| MMP14 | MOB3A | 0.662958 | 3 | 0 | 3 |
For details and further investigation, click here
