| Full name: spindle and centriole associated protein 1 | Alias Symbol: SPICE | ||
| Type: protein-coding gene | Cytoband: 3q13.2 | ||
| Entrez ID: 152185 | HGNC ID: HGNC:25083 | Ensembl Gene: ENSG00000163611 | OMIM ID: 613447 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPICE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPICE1 | 152185 | 234995_at | 0.1177 | 0.8727 | |
| GSE20347 | SPICE1 | 152185 | 215094_at | -0.0021 | 0.9744 | |
| GSE23400 | SPICE1 | 152185 | 215094_at | -0.0302 | 0.1915 | |
| GSE26886 | SPICE1 | 152185 | 234995_at | 1.4194 | 0.0000 | |
| GSE29001 | SPICE1 | 152185 | 215094_at | 0.0372 | 0.7909 | |
| GSE38129 | SPICE1 | 152185 | 215094_at | -0.0485 | 0.3362 | |
| GSE45670 | SPICE1 | 152185 | 234995_at | 0.2469 | 0.3004 | |
| GSE53622 | SPICE1 | 152185 | 65574 | 0.4938 | 0.0000 | |
| GSE53624 | SPICE1 | 152185 | 65574 | 0.3420 | 0.0028 | |
| GSE63941 | SPICE1 | 152185 | 234995_at | 1.0841 | 0.1158 | |
| GSE77861 | SPICE1 | 152185 | 234995_at | 0.3605 | 0.3145 | |
| GSE97050 | SPICE1 | 152185 | A_33_P3388006 | 0.1977 | 0.3138 | |
| SRP007169 | SPICE1 | 152185 | RNAseq | 0.6708 | 0.2015 | |
| SRP008496 | SPICE1 | 152185 | RNAseq | 0.8479 | 0.0241 | |
| SRP064894 | SPICE1 | 152185 | RNAseq | 0.3729 | 0.1029 | |
| SRP133303 | SPICE1 | 152185 | RNAseq | 0.2615 | 0.2236 | |
| SRP159526 | SPICE1 | 152185 | RNAseq | 0.4193 | 0.0333 | |
| SRP193095 | SPICE1 | 152185 | RNAseq | 0.2409 | 0.0294 | |
| SRP219564 | SPICE1 | 152185 | RNAseq | 0.3724 | 0.2269 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPICE1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SPICE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPICE1 | 152185 | 16 | 1 | 13 | |
| GSE20123 | SPICE1 | 152185 | 16 | 1 | 13 | |
| GSE43470 | SPICE1 | 152185 | 21 | 1 | 21 | |
| GSE46452 | SPICE1 | 152185 | 13 | 5 | 41 | |
| GSE47630 | SPICE1 | 152185 | 16 | 6 | 18 | |
| GSE54993 | SPICE1 | 152185 | 2 | 6 | 62 | |
| GSE54994 | SPICE1 | 152185 | 29 | 4 | 20 | |
| GSE60625 | SPICE1 | 152185 | 0 | 6 | 5 | |
| GSE74703 | SPICE1 | 152185 | 17 | 1 | 18 | |
| GSE74704 | SPICE1 | 152185 | 12 | 1 | 7 | |
| TCGA | SPICE1 | 152185 | 52 | 7 | 37 |
Total number of gains: 194; Total number of losses: 39; Total Number of normals: 255.
Somatic mutations of SPICE1:
Generating mutation plots.
Highly correlated genes for SPICE1:
Showing top 20/353 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPICE1 | TCF7L2 | 0.786724 | 3 | 0 | 3 |
| SPICE1 | GPATCH1 | 0.736724 | 3 | 0 | 3 |
| SPICE1 | FADD | 0.73209 | 3 | 0 | 3 |
| SPICE1 | WDR25 | 0.728099 | 3 | 0 | 3 |
| SPICE1 | GPR160 | 0.727587 | 3 | 0 | 3 |
| SPICE1 | ANGEL2 | 0.720743 | 3 | 0 | 3 |
| SPICE1 | PROCR | 0.716501 | 3 | 0 | 3 |
| SPICE1 | ZNF121 | 0.713405 | 3 | 0 | 3 |
| SPICE1 | ZNF627 | 0.707985 | 3 | 0 | 3 |
| SPICE1 | ZNF184 | 0.707314 | 3 | 0 | 3 |
| SPICE1 | YIPF2 | 0.705371 | 3 | 0 | 3 |
| SPICE1 | PDRG1 | 0.698827 | 3 | 0 | 3 |
| SPICE1 | TOP1MT | 0.696174 | 3 | 0 | 3 |
| SPICE1 | EXOSC3 | 0.694512 | 3 | 0 | 3 |
| SPICE1 | ZNF507 | 0.694363 | 4 | 0 | 4 |
| SPICE1 | PPP1R37 | 0.692688 | 4 | 0 | 3 |
| SPICE1 | HSD17B6 | 0.691339 | 3 | 0 | 3 |
| SPICE1 | ZCCHC7 | 0.688037 | 3 | 0 | 3 |
| SPICE1 | ENPP5 | 0.686658 | 4 | 0 | 4 |
| SPICE1 | SP100 | 0.68235 | 3 | 0 | 3 |
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