FADD

 

Full name: Fas associated via death domain Alias Symbol: MORT1|GIG3
Type: protein-coding gene Cytoband: 11q13.3
Entrez ID: 8772 HGNC ID: HGNC:3573 Ensembl Gene: ENSG00000168040 OMIM ID: 602457
Drug and gene relationship at DGIdb
Screen Evidence:

 

FADD involved pathways:

KEGG pathway Description View
hsa04210Apoptosis
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04668TNF signaling pathway
hsa05010Alzheimer's disease
hsa05142Chagas disease (American trypanosomiasis)
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05168Herpes simplex infection
hsa05200Pathways in cancer

 

Expression of FADD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FADD 8772 202535_at 1.8387 0.1911
GSE20347 FADD 8772 202535_at 1.7208 0.0003
GSE23400 FADD 8772 202535_at 1.3072 0.0000
GSE26886 FADD 8772 202535_at 1.6823 0.0001
GSE29001 FADD 8772 202535_at 1.6489 0.0004
GSE38129 FADD 8772 202535_at 1.7172 0.0000
GSE45670 FADD 8772 202535_at 0.9709 0.0265
GSE63941 FADD 8772 202535_at 1.8647 0.0467
GSE77861 FADD 8772 202535_at 1.2146 0.1536
GSE97050 FADD 8772 A_23_P86917 1.4471 0.0781
SRP007169 FADD 8772 RNAseq 1.7104 0.0167
SRP008496 FADD 8772 RNAseq 1.9485 0.0090
SRP064894 FADD 8772 RNAseq 2.2902 0.0000
SRP133303 FADD 8772 RNAseq 2.2655 0.0000
SRP159526 FADD 8772 RNAseq 2.9893 0.0000
SRP193095 FADD 8772 RNAseq 2.2798 0.0000
SRP219564 FADD 8772 RNAseq 2.6982 0.0001
TCGA FADD 8772 RNAseq 0.5806 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by FADD expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of FADD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FADD 8772 19 2 9
GSE20123 FADD 8772 20 1 9
GSE43470 FADD 8772 15 2 26
GSE46452 FADD 8772 33 3 23
GSE47630 FADD 8772 18 2 20
GSE54993 FADD 8772 1 25 44
GSE54994 FADD 8772 26 5 22
GSE60625 FADD 8772 0 8 3
GSE74703 FADD 8772 12 1 23
GSE74704 FADD 8772 13 0 7
TCGA FADD 8772 64 2 30

Total number of gains: 221; Total number of losses: 51; Total Number of normals: 216.  

 

Somatic mutations of FADD:

 

Generating mutation plots.

 

Highly correlated genes for FADD:

 

Showing top 20/1458 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FADDPPFIA10.9090511011
FADDANO10.79802811011
FADDA4GALT0.755975303
FADDENPP50.755483303
FADDMRPL210.755185707
FADDBAD0.752885303
FADDTRIM590.751581303
FADDSPSB20.748287303
FADDASB70.747958303
FADDFLVCR10.744481303
FADDSPICE10.73209303
FADDSAP1300.729323303
FADDANLN0.729125404
FADDDHRS130.724356303
FADDZDHHC160.724067404
FADDCHML0.720176303
FADDGTF2F20.715737303
FADDMASTL0.711955403
FADDUBTD20.711183505
FADDCTTN0.7095981008

For details and further investigation, click here