| Full name: hydroxysteroid 17-beta dehydrogenase 6 | Alias Symbol: HSE|RODH|SDR9C6 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 8630 | HGNC ID: HGNC:23316 | Ensembl Gene: ENSG00000025423 | OMIM ID: 606623 |
| Drug and gene relationship at DGIdb | |||
Expression of HSD17B6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B6 | 8630 | 205700_at | -0.2559 | 0.7765 | |
| GSE20347 | HSD17B6 | 8630 | 205700_at | 0.5493 | 0.0214 | |
| GSE23400 | HSD17B6 | 8630 | 205700_at | 0.0064 | 0.9116 | |
| GSE26886 | HSD17B6 | 8630 | 205700_at | 1.6975 | 0.0000 | |
| GSE29001 | HSD17B6 | 8630 | 205700_at | 0.9021 | 0.0024 | |
| GSE38129 | HSD17B6 | 8630 | 205700_at | 0.4642 | 0.1504 | |
| GSE45670 | HSD17B6 | 8630 | 205700_at | -1.0189 | 0.0069 | |
| GSE53622 | HSD17B6 | 8630 | 82895 | 0.0983 | 0.5120 | |
| GSE53624 | HSD17B6 | 8630 | 82895 | -0.1538 | 0.3147 | |
| GSE63941 | HSD17B6 | 8630 | 205700_at | -2.8058 | 0.0055 | |
| GSE77861 | HSD17B6 | 8630 | 205700_at | 0.5481 | 0.0673 | |
| GSE97050 | HSD17B6 | 8630 | A_23_P25030 | 0.3311 | 0.2385 | |
| SRP064894 | HSD17B6 | 8630 | RNAseq | -0.8838 | 0.0030 | |
| SRP133303 | HSD17B6 | 8630 | RNAseq | 0.0030 | 0.9930 | |
| SRP159526 | HSD17B6 | 8630 | RNAseq | -0.3698 | 0.5030 | |
| SRP193095 | HSD17B6 | 8630 | RNAseq | 1.4698 | 0.0000 | |
| SRP219564 | HSD17B6 | 8630 | RNAseq | -1.2215 | 0.0751 | |
| TCGA | HSD17B6 | 8630 | RNAseq | -0.2900 | 0.1169 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by HSD17B6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B6 | 8630 | 7 | 2 | 21 | |
| GSE20123 | HSD17B6 | 8630 | 7 | 1 | 22 | |
| GSE43470 | HSD17B6 | 8630 | 3 | 0 | 40 | |
| GSE46452 | HSD17B6 | 8630 | 8 | 1 | 50 | |
| GSE47630 | HSD17B6 | 8630 | 10 | 2 | 28 | |
| GSE54993 | HSD17B6 | 8630 | 0 | 5 | 65 | |
| GSE54994 | HSD17B6 | 8630 | 4 | 1 | 48 | |
| GSE60625 | HSD17B6 | 8630 | 0 | 0 | 11 | |
| GSE74703 | HSD17B6 | 8630 | 3 | 0 | 33 | |
| GSE74704 | HSD17B6 | 8630 | 4 | 1 | 15 | |
| TCGA | HSD17B6 | 8630 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of HSD17B6:
Generating mutation plots.
Highly correlated genes for HSD17B6:
Showing top 20/328 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B6 | VMA21 | 0.71182 | 3 | 0 | 3 |
| HSD17B6 | COLGALT1 | 0.71001 | 3 | 0 | 3 |
| HSD17B6 | DGUOK | 0.708709 | 3 | 0 | 3 |
| HSD17B6 | GTPBP4 | 0.708282 | 3 | 0 | 3 |
| HSD17B6 | GOLT1B | 0.701163 | 3 | 0 | 3 |
| HSD17B6 | ZBTB41 | 0.695809 | 3 | 0 | 3 |
| HSD17B6 | CDK5RAP1 | 0.695273 | 4 | 0 | 4 |
| HSD17B6 | SPICE1 | 0.691339 | 3 | 0 | 3 |
| HSD17B6 | RAD54L | 0.690099 | 3 | 0 | 3 |
| HSD17B6 | LRRC58 | 0.687908 | 3 | 0 | 3 |
| HSD17B6 | DDX54 | 0.681966 | 3 | 0 | 3 |
| HSD17B6 | ERVMER34-1 | 0.678791 | 4 | 0 | 3 |
| HSD17B6 | CTSL | 0.678702 | 3 | 0 | 3 |
| HSD17B6 | MORC4 | 0.670192 | 3 | 0 | 3 |
| HSD17B6 | ACBD6 | 0.668562 | 3 | 0 | 3 |
| HSD17B6 | GTF2E1 | 0.664402 | 3 | 0 | 3 |
| HSD17B6 | PLOD1 | 0.661141 | 3 | 0 | 3 |
| HSD17B6 | TBL1XR1 | 0.65681 | 5 | 0 | 4 |
| HSD17B6 | POFUT1 | 0.655541 | 4 | 0 | 3 |
| HSD17B6 | ZNF627 | 0.654516 | 3 | 0 | 3 |
For details and further investigation, click here
