| Full name: protein C receptor | Alias Symbol: EPCR|CCD41|CD201 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 10544 | HGNC ID: HGNC:9452 | Ensembl Gene: ENSG00000101000 | OMIM ID: 600646 |
| Drug and gene relationship at DGIdb | |||
PROCR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of PROCR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PROCR | 10544 | 203650_at | 1.0039 | 0.3612 | |
| GSE20347 | PROCR | 10544 | 203650_at | 1.3374 | 0.0000 | |
| GSE23400 | PROCR | 10544 | 203650_at | 0.5455 | 0.0000 | |
| GSE26886 | PROCR | 10544 | 203650_at | 2.1561 | 0.0000 | |
| GSE29001 | PROCR | 10544 | 203650_at | 1.8444 | 0.0001 | |
| GSE38129 | PROCR | 10544 | 203650_at | 1.1012 | 0.0002 | |
| GSE45670 | PROCR | 10544 | 203650_at | 0.8245 | 0.1195 | |
| GSE53622 | PROCR | 10544 | 40483 | 1.0045 | 0.0000 | |
| GSE53624 | PROCR | 10544 | 40483 | 1.4530 | 0.0000 | |
| GSE63941 | PROCR | 10544 | 203650_at | -1.9534 | 0.0883 | |
| GSE77861 | PROCR | 10544 | 203650_at | 0.8914 | 0.0622 | |
| GSE97050 | PROCR | 10544 | A_23_P80040 | 0.7094 | 0.1269 | |
| SRP007169 | PROCR | 10544 | RNAseq | 1.7099 | 0.0004 | |
| SRP008496 | PROCR | 10544 | RNAseq | 1.2983 | 0.0001 | |
| SRP064894 | PROCR | 10544 | RNAseq | 1.4917 | 0.0000 | |
| SRP133303 | PROCR | 10544 | RNAseq | 1.2904 | 0.0006 | |
| SRP159526 | PROCR | 10544 | RNAseq | 1.9426 | 0.0004 | |
| SRP193095 | PROCR | 10544 | RNAseq | 1.7905 | 0.0000 | |
| SRP219564 | PROCR | 10544 | RNAseq | 1.5348 | 0.0380 | |
| TCGA | PROCR | 10544 | RNAseq | 0.1914 | 0.0996 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by PROCR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PROCR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PROCR | 10544 | 16 | 0 | 14 | |
| GSE20123 | PROCR | 10544 | 16 | 0 | 14 | |
| GSE43470 | PROCR | 10544 | 13 | 0 | 30 | |
| GSE46452 | PROCR | 10544 | 29 | 0 | 30 | |
| GSE47630 | PROCR | 10544 | 25 | 0 | 15 | |
| GSE54993 | PROCR | 10544 | 0 | 17 | 53 | |
| GSE54994 | PROCR | 10544 | 25 | 0 | 28 | |
| GSE60625 | PROCR | 10544 | 0 | 0 | 11 | |
| GSE74703 | PROCR | 10544 | 11 | 0 | 25 | |
| GSE74704 | PROCR | 10544 | 11 | 0 | 9 | |
| TCGA | PROCR | 10544 | 49 | 3 | 44 |
Total number of gains: 195; Total number of losses: 20; Total Number of normals: 273.
Somatic mutations of PROCR:
Generating mutation plots.
Highly correlated genes for PROCR:
Showing top 20/1262 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PROCR | PHF20 | 0.749249 | 3 | 0 | 3 |
| PROCR | ALKBH6 | 0.739615 | 3 | 0 | 3 |
| PROCR | GUCY1A2 | 0.736658 | 4 | 0 | 4 |
| PROCR | DDX60L | 0.730744 | 4 | 0 | 4 |
| PROCR | FCGR3A | 0.727092 | 3 | 0 | 3 |
| PROCR | SPICE1 | 0.716501 | 3 | 0 | 3 |
| PROCR | FMNL2 | 0.704541 | 7 | 0 | 7 |
| PROCR | NACC1 | 0.702053 | 3 | 0 | 3 |
| PROCR | PDK1 | 0.695132 | 3 | 0 | 3 |
| PROCR | WDR54 | 0.694421 | 7 | 0 | 7 |
| PROCR | SLC39A14 | 0.689985 | 11 | 0 | 11 |
| PROCR | CD276 | 0.688915 | 4 | 0 | 4 |
| PROCR | SPON2 | 0.688277 | 3 | 0 | 3 |
| PROCR | CRTC2 | 0.685772 | 3 | 0 | 3 |
| PROCR | AURKAIP1 | 0.685035 | 3 | 0 | 3 |
| PROCR | LPCAT1 | 0.684921 | 11 | 0 | 11 |
| PROCR | TGFBI | 0.684107 | 11 | 0 | 10 |
| PROCR | ISY1 | 0.684097 | 3 | 0 | 3 |
| PROCR | COMMD2 | 0.683205 | 3 | 0 | 3 |
| PROCR | UBE2J2 | 0.681399 | 3 | 0 | 3 |
For details and further investigation, click here
