EXOSC3

 

Full name: exosome component 3 Alias Symbol: hRrp40p|Rrp40p|RRP40|CGI-102|p10|hRrp-40
Type: protein-coding gene Cytoband: 9p13.2
Entrez ID: 51010 HGNC ID: HGNC:17944 Ensembl Gene: ENSG00000107371 OMIM ID: 606489
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of EXOSC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EXOSC3 51010 227916_x_at 0.4322 0.1257
GSE26886 EXOSC3 51010 227916_x_at 0.6496 0.0016
GSE45670 EXOSC3 51010 227916_x_at 0.8643 0.0000
GSE53622 EXOSC3 51010 99173 0.3810 0.0000
GSE53624 EXOSC3 51010 99173 0.8236 0.0000
GSE63941 EXOSC3 51010 227916_x_at 0.7265 0.1043
GSE77861 EXOSC3 51010 227916_x_at 0.0364 0.8840
GSE97050 EXOSC3 51010 A_23_P123905 0.2145 0.4573
SRP007169 EXOSC3 51010 RNAseq 0.6908 0.0940
SRP008496 EXOSC3 51010 RNAseq 0.9239 0.0037
SRP064894 EXOSC3 51010 RNAseq 0.5386 0.0082
SRP133303 EXOSC3 51010 RNAseq -0.1564 0.2870
SRP159526 EXOSC3 51010 RNAseq 0.1791 0.5899
SRP193095 EXOSC3 51010 RNAseq -0.2487 0.0199
SRP219564 EXOSC3 51010 RNAseq 0.6432 0.1451
TCGA EXOSC3 51010 RNAseq 0.1775 0.0156

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by EXOSC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EXOSC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EXOSC3 51010 4 13 13
GSE20123 EXOSC3 51010 4 13 13
GSE43470 EXOSC3 51010 1 12 30
GSE46452 EXOSC3 51010 6 15 38
GSE47630 EXOSC3 51010 1 20 19
GSE54993 EXOSC3 51010 6 0 64
GSE54994 EXOSC3 51010 5 13 35
GSE60625 EXOSC3 51010 0 0 11
GSE74703 EXOSC3 51010 1 8 27
GSE74704 EXOSC3 51010 1 9 10
TCGA EXOSC3 51010 14 45 37

Total number of gains: 43; Total number of losses: 148; Total Number of normals: 297.  

 

Somatic mutations of EXOSC3:

 

Generating mutation plots.

 

Highly correlated genes for EXOSC3:

 

Showing top 20/1113 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EXOSC3TOMM50.72139707
EXOSC3TMEM2230.715199404
EXOSC3CXCL160.71112303
EXOSC3SLC1A50.70698303
EXOSC3NIPBL0.705975303
EXOSC3RCL10.700408606
EXOSC3SPICE10.694512303
EXOSC3SSRP10.69332606
EXOSC3POLR1A0.683877303
EXOSC3MTERF30.683164303
EXOSC3NCBP10.683093403
EXOSC3ARHGAP180.682715303
EXOSC3KNOP10.681377303
EXOSC3TMEM63B0.679437303
EXOSC3GART0.679362605
EXOSC3EME10.679241505
EXOSC3C10orf550.676418404
EXOSC3WDR30.675275503
EXOSC3MELK0.674048908
EXOSC3TAF4B0.672049403

For details and further investigation, click here