| Full name: SRSF protein kinase 2 | Alias Symbol: SFRSK2 | ||
| Type: protein-coding gene | Cytoband: 7q22.3 | ||
| Entrez ID: 6733 | HGNC ID: HGNC:11306 | Ensembl Gene: ENSG00000135250 | OMIM ID: 602980 |
| Drug and gene relationship at DGIdb | |||
Expression of SRPK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRPK2 | 6733 | 203181_x_at | 0.3054 | 0.3218 | |
| GSE20347 | SRPK2 | 6733 | 203181_x_at | 0.5198 | 0.0002 | |
| GSE23400 | SRPK2 | 6733 | 203181_x_at | 0.2690 | 0.0057 | |
| GSE26886 | SRPK2 | 6733 | 203181_x_at | 0.7595 | 0.0002 | |
| GSE29001 | SRPK2 | 6733 | 203181_x_at | 0.6074 | 0.0030 | |
| GSE38129 | SRPK2 | 6733 | 203181_x_at | 0.4575 | 0.0012 | |
| GSE45670 | SRPK2 | 6733 | 203182_s_at | 0.5217 | 0.0031 | |
| GSE53622 | SRPK2 | 6733 | 62714 | 0.5458 | 0.0000 | |
| GSE53624 | SRPK2 | 6733 | 62714 | 0.5830 | 0.0000 | |
| GSE63941 | SRPK2 | 6733 | 203182_s_at | -0.6027 | 0.0983 | |
| GSE77861 | SRPK2 | 6733 | 203182_s_at | 0.6933 | 0.0079 | |
| GSE97050 | SRPK2 | 6733 | A_23_P406438 | 0.1658 | 0.6111 | |
| SRP007169 | SRPK2 | 6733 | RNAseq | 0.6885 | 0.0494 | |
| SRP008496 | SRPK2 | 6733 | RNAseq | 1.1844 | 0.0000 | |
| SRP064894 | SRPK2 | 6733 | RNAseq | 0.4725 | 0.0414 | |
| SRP133303 | SRPK2 | 6733 | RNAseq | 0.6649 | 0.0000 | |
| SRP159526 | SRPK2 | 6733 | RNAseq | 0.3903 | 0.1518 | |
| SRP193095 | SRPK2 | 6733 | RNAseq | 0.7385 | 0.0000 | |
| SRP219564 | SRPK2 | 6733 | RNAseq | 0.3399 | 0.3671 | |
| TCGA | SRPK2 | 6733 | RNAseq | 0.1584 | 0.0035 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SRPK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRPK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRPK2 | 6733 | 13 | 0 | 17 | |
| GSE20123 | SRPK2 | 6733 | 13 | 0 | 17 | |
| GSE43470 | SRPK2 | 6733 | 7 | 1 | 35 | |
| GSE46452 | SRPK2 | 6733 | 10 | 1 | 48 | |
| GSE47630 | SRPK2 | 6733 | 8 | 3 | 29 | |
| GSE54993 | SRPK2 | 6733 | 2 | 10 | 58 | |
| GSE54994 | SRPK2 | 6733 | 14 | 4 | 35 | |
| GSE60625 | SRPK2 | 6733 | 0 | 0 | 11 | |
| GSE74703 | SRPK2 | 6733 | 7 | 1 | 28 | |
| GSE74704 | SRPK2 | 6733 | 8 | 0 | 12 | |
| TCGA | SRPK2 | 6733 | 53 | 9 | 34 |
Total number of gains: 135; Total number of losses: 29; Total Number of normals: 324.
Somatic mutations of SRPK2:
Generating mutation plots.
Highly correlated genes for SRPK2:
Showing top 20/1386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRPK2 | MRPS9 | 0.759055 | 3 | 0 | 3 |
| SRPK2 | ARL13B | 0.758719 | 5 | 0 | 5 |
| SRPK2 | SLC6A6 | 0.753666 | 3 | 0 | 3 |
| SRPK2 | DHX40 | 0.753398 | 3 | 0 | 3 |
| SRPK2 | CPNE1 | 0.751941 | 3 | 0 | 3 |
| SRPK2 | RLIM | 0.750236 | 3 | 0 | 3 |
| SRPK2 | GCSH | 0.74923 | 3 | 0 | 3 |
| SRPK2 | UCKL1 | 0.746763 | 3 | 0 | 3 |
| SRPK2 | ALKBH6 | 0.741857 | 5 | 0 | 5 |
| SRPK2 | CRTC2 | 0.7354 | 3 | 0 | 3 |
| SRPK2 | NBAS | 0.733542 | 3 | 0 | 3 |
| SRPK2 | SSBP4 | 0.729907 | 3 | 0 | 3 |
| SRPK2 | YWHAG | 0.729162 | 5 | 0 | 5 |
| SRPK2 | FAM168B | 0.728575 | 3 | 0 | 3 |
| SRPK2 | ZCRB1 | 0.726042 | 3 | 0 | 3 |
| SRPK2 | BCL9L | 0.721662 | 3 | 0 | 3 |
| SRPK2 | PCGF2 | 0.717938 | 3 | 0 | 3 |
| SRPK2 | NSMAF | 0.715011 | 3 | 0 | 3 |
| SRPK2 | WDR81 | 0.714544 | 4 | 0 | 3 |
| SRPK2 | ZSCAN21 | 0.714074 | 3 | 0 | 3 |
For details and further investigation, click here
