| Full name: glycine cleavage system protein H | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q23.2 | ||
| Entrez ID: 2653 | HGNC ID: HGNC:4208 | Ensembl Gene: ENSG00000140905 | OMIM ID: 238330 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GCSH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCSH | 2653 | 213129_s_at | 0.6813 | 0.0768 | |
| GSE20347 | GCSH | 2653 | 213129_s_at | 0.5217 | 0.0035 | |
| GSE23400 | GCSH | 2653 | 213133_s_at | 0.3893 | 0.0000 | |
| GSE26886 | GCSH | 2653 | 213129_s_at | 0.7492 | 0.0007 | |
| GSE29001 | GCSH | 2653 | 213129_s_at | 0.4849 | 0.2602 | |
| GSE38129 | GCSH | 2653 | 213129_s_at | 0.6613 | 0.0000 | |
| GSE45670 | GCSH | 2653 | 213129_s_at | 0.2389 | 0.1888 | |
| GSE53622 | GCSH | 2653 | 97196 | -0.0297 | 0.7280 | |
| GSE53624 | GCSH | 2653 | 97196 | 0.2984 | 0.0000 | |
| GSE63941 | GCSH | 2653 | 213129_s_at | 0.3949 | 0.4720 | |
| GSE77861 | GCSH | 2653 | 213129_s_at | 0.3304 | 0.2581 | |
| GSE97050 | GCSH | 2653 | A_23_P117933 | -0.3466 | 0.2180 | |
| SRP007169 | GCSH | 2653 | RNAseq | 1.2863 | 0.0054 | |
| SRP008496 | GCSH | 2653 | RNAseq | 1.1184 | 0.0004 | |
| SRP064894 | GCSH | 2653 | RNAseq | 0.1260 | 0.4736 | |
| SRP133303 | GCSH | 2653 | RNAseq | 0.5104 | 0.0014 | |
| SRP159526 | GCSH | 2653 | RNAseq | 0.8434 | 0.0374 | |
| SRP193095 | GCSH | 2653 | RNAseq | 0.1259 | 0.4567 | |
| SRP219564 | GCSH | 2653 | RNAseq | 0.2120 | 0.5661 | |
| TCGA | GCSH | 2653 | RNAseq | 0.5158 | 0.0062 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GCSH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCSH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCSH | 2653 | 5 | 2 | 23 | |
| GSE20123 | GCSH | 2653 | 5 | 2 | 23 | |
| GSE43470 | GCSH | 2653 | 2 | 8 | 33 | |
| GSE46452 | GCSH | 2653 | 37 | 2 | 20 | |
| GSE47630 | GCSH | 2653 | 11 | 8 | 21 | |
| GSE54993 | GCSH | 2653 | 2 | 4 | 64 | |
| GSE54994 | GCSH | 2653 | 7 | 10 | 36 | |
| GSE60625 | GCSH | 2653 | 4 | 0 | 7 | |
| GSE74703 | GCSH | 2653 | 2 | 6 | 28 | |
| GSE74704 | GCSH | 2653 | 3 | 2 | 15 | |
| TCGA | GCSH | 2653 | 24 | 16 | 56 |
Total number of gains: 102; Total number of losses: 60; Total Number of normals: 326.
Somatic mutations of GCSH:
Generating mutation plots.
Highly correlated genes for GCSH:
Showing top 20/1144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCSH | KIAA1586 | 0.769699 | 3 | 0 | 3 |
| GCSH | ZCCHC17 | 0.761414 | 3 | 0 | 3 |
| GCSH | MMP15 | 0.752349 | 3 | 0 | 3 |
| GCSH | SRPK2 | 0.74923 | 3 | 0 | 3 |
| GCSH | CCNH | 0.745987 | 3 | 0 | 3 |
| GCSH | ZNF8 | 0.744473 | 3 | 0 | 3 |
| GCSH | SLC45A4 | 0.74009 | 4 | 0 | 4 |
| GCSH | NEK6 | 0.734085 | 3 | 0 | 3 |
| GCSH | CAMKK2 | 0.732057 | 3 | 0 | 3 |
| GCSH | MRPL32 | 0.724364 | 3 | 0 | 3 |
| GCSH | RPS6KA3 | 0.721962 | 3 | 0 | 3 |
| GCSH | TP53I13 | 0.720709 | 3 | 0 | 3 |
| GCSH | CWF19L2 | 0.715399 | 3 | 0 | 3 |
| GCSH | UHRF1BP1 | 0.707542 | 3 | 0 | 3 |
| GCSH | SP100 | 0.702105 | 3 | 0 | 3 |
| GCSH | RP9 | 0.697454 | 4 | 0 | 3 |
| GCSH | SMCR8 | 0.697225 | 4 | 0 | 3 |
| GCSH | EDEM2 | 0.693858 | 3 | 0 | 3 |
| GCSH | C20orf194 | 0.691982 | 3 | 0 | 3 |
| GCSH | ST3GAL5 | 0.687273 | 3 | 0 | 3 |
For details and further investigation, click here
