| Full name: signal transducing adaptor molecule | Alias Symbol: STAM1 | ||
| Type: protein-coding gene | Cytoband: 10p12.33 | ||
| Entrez ID: 8027 | HGNC ID: HGNC:11357 | Ensembl Gene: ENSG00000136738 | OMIM ID: 601899 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
STAM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of STAM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STAM | 8027 | 203544_s_at | -0.1605 | 0.8215 | |
| GSE20347 | STAM | 8027 | 203544_s_at | -0.3361 | 0.0751 | |
| GSE23400 | STAM | 8027 | 203544_s_at | 0.0098 | 0.9226 | |
| GSE26886 | STAM | 8027 | 203544_s_at | -0.7910 | 0.0305 | |
| GSE29001 | STAM | 8027 | 203544_s_at | -0.1587 | 0.5609 | |
| GSE38129 | STAM | 8027 | 203544_s_at | -0.1301 | 0.3585 | |
| GSE45670 | STAM | 8027 | 203544_s_at | -0.0568 | 0.6975 | |
| GSE53622 | STAM | 8027 | 39461 | -0.1107 | 0.1005 | |
| GSE53624 | STAM | 8027 | 39461 | -0.0287 | 0.7179 | |
| GSE63941 | STAM | 8027 | 203544_s_at | -1.5817 | 0.0009 | |
| GSE77861 | STAM | 8027 | 203544_s_at | -0.4668 | 0.0851 | |
| GSE97050 | STAM | 8027 | A_33_P3287840 | 0.2468 | 0.4174 | |
| SRP007169 | STAM | 8027 | RNAseq | 0.3250 | 0.4515 | |
| SRP008496 | STAM | 8027 | RNAseq | 0.7255 | 0.0123 | |
| SRP064894 | STAM | 8027 | RNAseq | -0.2024 | 0.4227 | |
| SRP133303 | STAM | 8027 | RNAseq | 0.0392 | 0.8411 | |
| SRP159526 | STAM | 8027 | RNAseq | -0.6851 | 0.0638 | |
| SRP193095 | STAM | 8027 | RNAseq | -0.1661 | 0.0817 | |
| SRP219564 | STAM | 8027 | RNAseq | -0.4371 | 0.2521 | |
| TCGA | STAM | 8027 | RNAseq | -0.0858 | 0.1357 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by STAM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STAM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STAM | 8027 | 3 | 8 | 19 | |
| GSE20123 | STAM | 8027 | 3 | 7 | 20 | |
| GSE43470 | STAM | 8027 | 3 | 4 | 36 | |
| GSE46452 | STAM | 8027 | 1 | 14 | 44 | |
| GSE47630 | STAM | 8027 | 5 | 15 | 20 | |
| GSE54993 | STAM | 8027 | 10 | 0 | 60 | |
| GSE54994 | STAM | 8027 | 4 | 9 | 40 | |
| GSE60625 | STAM | 8027 | 0 | 0 | 11 | |
| GSE74703 | STAM | 8027 | 2 | 3 | 31 | |
| GSE74704 | STAM | 8027 | 0 | 6 | 14 | |
| TCGA | STAM | 8027 | 18 | 26 | 52 |
Total number of gains: 49; Total number of losses: 92; Total Number of normals: 347.
Somatic mutations of STAM:
Generating mutation plots.
Highly correlated genes for STAM:
Showing top 20/446 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STAM | TMEM19 | 0.798046 | 3 | 0 | 3 |
| STAM | AMPD3 | 0.777244 | 3 | 0 | 3 |
| STAM | ARHGEF6 | 0.76894 | 3 | 0 | 3 |
| STAM | VASN | 0.764343 | 3 | 0 | 3 |
| STAM | ZNF578 | 0.746014 | 3 | 0 | 3 |
| STAM | TMEM117 | 0.745331 | 3 | 0 | 3 |
| STAM | MTPN | 0.74358 | 3 | 0 | 3 |
| STAM | GYPC | 0.74231 | 3 | 0 | 3 |
| STAM | FOPNL | 0.737423 | 3 | 0 | 3 |
| STAM | EPG5 | 0.735971 | 3 | 0 | 3 |
| STAM | TTC23 | 0.733633 | 3 | 0 | 3 |
| STAM | CCDC25 | 0.733188 | 3 | 0 | 3 |
| STAM | PDGFRA | 0.732157 | 3 | 0 | 3 |
| STAM | SUSD1 | 0.728583 | 4 | 0 | 4 |
| STAM | LRRC40 | 0.719777 | 4 | 0 | 3 |
| STAM | PTTG1IP | 0.716786 | 3 | 0 | 3 |
| STAM | PDE5A | 0.713621 | 3 | 0 | 3 |
| STAM | ERCC6 | 0.711102 | 3 | 0 | 3 |
| STAM | VPS37A | 0.711099 | 3 | 0 | 3 |
| STAM | ZCCHC9 | 0.710292 | 5 | 0 | 4 |
For details and further investigation, click here
