PDGFRA

 

Full name: platelet derived growth factor receptor alpha Alias Symbol: CD140a|PDGFR2|GAS9
Type: protein-coding gene Cytoband: 4q12
Entrez ID: 5156 HGNC ID: HGNC:8803 Ensembl Gene: ENSG00000134853 OMIM ID: 173490
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PDGFRA involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05231Choline metabolism in cancer

 

Expression of PDGFRA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDGFRA 5156 203131_at -1.7498 0.0599
GSE20347 PDGFRA 5156 203131_at -0.6868 0.0044
GSE23400 PDGFRA 5156 203131_at -0.5773 0.0024
GSE26886 PDGFRA 5156 203131_at -1.5197 0.0071
GSE29001 PDGFRA 5156 203131_at -1.5316 0.0001
GSE38129 PDGFRA 5156 203131_at -0.9809 0.0061
GSE45670 PDGFRA 5156 203131_at -1.8980 0.0003
GSE53622 PDGFRA 5156 90444 -0.3859 0.0125
GSE53624 PDGFRA 5156 90444 -0.7997 0.0000
GSE63941 PDGFRA 5156 215305_at -2.3957 0.0000
GSE77861 PDGFRA 5156 203131_at -0.7155 0.2410
GSE97050 PDGFRA 5156 A_23_P300033 0.0694 0.8310
SRP007169 PDGFRA 5156 RNAseq 1.3155 0.0163
SRP008496 PDGFRA 5156 RNAseq 1.5951 0.0002
SRP064894 PDGFRA 5156 RNAseq 0.3541 0.3727
SRP133303 PDGFRA 5156 RNAseq -0.2924 0.2799
SRP159526 PDGFRA 5156 RNAseq 0.3173 0.3529
SRP193095 PDGFRA 5156 RNAseq 0.2283 0.4447
SRP219564 PDGFRA 5156 RNAseq 0.1850 0.7765
TCGA PDGFRA 5156 RNAseq -0.4668 0.0001

Upregulated datasets: 2; Downregulated datasets: 4.  

 

Survival by PDGFRA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDGFRA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDGFRA 5156 3 11 16
GSE20123 PDGFRA 5156 2 11 17
GSE43470 PDGFRA 5156 0 14 29
GSE46452 PDGFRA 5156 1 36 22
GSE47630 PDGFRA 5156 1 18 21
GSE54993 PDGFRA 5156 7 0 63
GSE54994 PDGFRA 5156 2 10 41
GSE60625 PDGFRA 5156 0 0 11
GSE74703 PDGFRA 5156 0 12 24
GSE74704 PDGFRA 5156 1 6 13
TCGA PDGFRA 5156 19 27 50

Total number of gains: 36; Total number of losses: 145; Total Number of normals: 307.  

 

Somatic mutations of PDGFRA:

 

Generating mutation plots.

 

Highly correlated genes for PDGFRA:

 

Showing top 20/1208 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDGFRAFNIP20.810783303
PDGFRANKAPL0.809185404
PDGFRALINC012790.804174303
PDGFRAAFF30.804103303
PDGFRAC11orf960.791154404
PDGFRADDR20.775358909
PDGFRAPDZRN3-AS10.773718303
PDGFRAMFAP40.7651909
PDGFRAPGM30.7645303
PDGFRAFGF70.76053808
PDGFRASNX250.75412303
PDGFRASLC16A40.750623808
PDGFRAPREX20.748938404
PDGFRACCDC800.744977606
PDGFRACNRIP10.737177807
PDGFRAOLFML10.736982909
PDGFRAFBLN50.736912909
PDGFRACYP4V20.73278404
PDGFRAARHGAP310.732741706
PDGFRASTAM0.732157303

For details and further investigation, click here