| Full name: VPS37A subunit of ESCRT-I | Alias Symbol: FLJ32642|HCRP1|SPG53 | ||
| Type: protein-coding gene | Cytoband: 8p22 | ||
| Entrez ID: 137492 | HGNC ID: HGNC:24928 | Ensembl Gene: ENSG00000155975 | OMIM ID: 609927 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS37A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS37A | 137492 | 225378_at | 0.1090 | 0.8516 | |
| GSE26886 | VPS37A | 137492 | 225378_at | 0.0581 | 0.8341 | |
| GSE45670 | VPS37A | 137492 | 225378_at | -0.0110 | 0.9577 | |
| GSE53622 | VPS37A | 137492 | 58850 | -0.2728 | 0.0000 | |
| GSE53624 | VPS37A | 137492 | 58850 | -0.2892 | 0.0000 | |
| GSE63941 | VPS37A | 137492 | 225378_at | -1.1270 | 0.0269 | |
| GSE77861 | VPS37A | 137492 | 225378_at | -0.1077 | 0.7579 | |
| GSE97050 | VPS37A | 137492 | A_23_P366328 | -0.1594 | 0.4406 | |
| SRP007169 | VPS37A | 137492 | RNAseq | -0.7366 | 0.0497 | |
| SRP008496 | VPS37A | 137492 | RNAseq | -0.7116 | 0.0021 | |
| SRP064894 | VPS37A | 137492 | RNAseq | -0.4484 | 0.0246 | |
| SRP133303 | VPS37A | 137492 | RNAseq | -0.2589 | 0.2088 | |
| SRP159526 | VPS37A | 137492 | RNAseq | -0.2643 | 0.0943 | |
| SRP193095 | VPS37A | 137492 | RNAseq | -0.5100 | 0.0000 | |
| SRP219564 | VPS37A | 137492 | RNAseq | -0.5381 | 0.0279 | |
| TCGA | VPS37A | 137492 | RNAseq | -0.0812 | 0.1165 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by VPS37A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS37A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS37A | 137492 | 3 | 11 | 16 | |
| GSE20123 | VPS37A | 137492 | 4 | 11 | 15 | |
| GSE43470 | VPS37A | 137492 | 4 | 8 | 31 | |
| GSE46452 | VPS37A | 137492 | 14 | 13 | 32 | |
| GSE47630 | VPS37A | 137492 | 10 | 8 | 22 | |
| GSE54993 | VPS37A | 137492 | 2 | 14 | 54 | |
| GSE54994 | VPS37A | 137492 | 8 | 18 | 27 | |
| GSE60625 | VPS37A | 137492 | 3 | 0 | 8 | |
| GSE74703 | VPS37A | 137492 | 4 | 7 | 25 | |
| GSE74704 | VPS37A | 137492 | 3 | 7 | 10 | |
| TCGA | VPS37A | 137492 | 14 | 41 | 41 |
Total number of gains: 69; Total number of losses: 138; Total Number of normals: 281.
Somatic mutations of VPS37A:
Generating mutation plots.
Highly correlated genes for VPS37A:
Showing top 20/113 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS37A | PTPN12 | 0.829417 | 3 | 0 | 3 |
| VPS37A | GLS | 0.761804 | 3 | 0 | 3 |
| VPS37A | USP32 | 0.757602 | 3 | 0 | 3 |
| VPS37A | THAP1 | 0.749161 | 3 | 0 | 3 |
| VPS37A | CBL | 0.741161 | 3 | 0 | 3 |
| VPS37A | PAK2 | 0.725851 | 3 | 0 | 3 |
| VPS37A | RAB11FIP5 | 0.725481 | 3 | 0 | 3 |
| VPS37A | STAMBP | 0.725251 | 3 | 0 | 3 |
| VPS37A | AMPD3 | 0.723437 | 3 | 0 | 3 |
| VPS37A | NDUFAF2 | 0.721 | 3 | 0 | 3 |
| VPS37A | STAM | 0.711099 | 3 | 0 | 3 |
| VPS37A | MYO5A | 0.703365 | 3 | 0 | 3 |
| VPS37A | GRPEL1 | 0.701443 | 3 | 0 | 3 |
| VPS37A | CTTNBP2NL | 0.695764 | 3 | 0 | 3 |
| VPS37A | ACVR1 | 0.695522 | 3 | 0 | 3 |
| VPS37A | CLIP4 | 0.690718 | 3 | 0 | 3 |
| VPS37A | BDKRB1 | 0.690422 | 3 | 0 | 3 |
| VPS37A | FOXC2 | 0.68925 | 3 | 0 | 3 |
| VPS37A | RABEP1 | 0.684668 | 3 | 0 | 3 |
| VPS37A | ALAS1 | 0.684051 | 4 | 0 | 4 |
For details and further investigation, click here
