| Full name: ectopic P-granules autophagy protein 5 homolog | Alias Symbol: hEPG5 | ||
| Type: protein-coding gene | Cytoband: 18q12.3-q21.1 | ||
| Entrez ID: 57724 | HGNC ID: HGNC:29331 | Ensembl Gene: ENSG00000152223 | OMIM ID: 615068 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EPG5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPG5 | 57724 | 227638_at | -0.3003 | 0.5209 | |
| GSE26886 | EPG5 | 57724 | 227638_at | -2.0821 | 0.0000 | |
| GSE45670 | EPG5 | 57724 | 227638_at | -0.4353 | 0.0486 | |
| GSE53622 | EPG5 | 57724 | 131416 | -0.4648 | 0.0000 | |
| GSE53624 | EPG5 | 57724 | 131416 | -0.2947 | 0.0002 | |
| GSE63941 | EPG5 | 57724 | 227638_at | -2.5059 | 0.0033 | |
| GSE77861 | EPG5 | 57724 | 227638_at | -0.7049 | 0.1541 | |
| GSE97050 | EPG5 | 57724 | A_24_P341923 | -0.5021 | 0.1859 | |
| SRP007169 | EPG5 | 57724 | RNAseq | -1.7646 | 0.0009 | |
| SRP008496 | EPG5 | 57724 | RNAseq | -1.2529 | 0.0005 | |
| SRP064894 | EPG5 | 57724 | RNAseq | -1.1476 | 0.0000 | |
| SRP133303 | EPG5 | 57724 | RNAseq | -0.4999 | 0.0000 | |
| SRP159526 | EPG5 | 57724 | RNAseq | -0.7827 | 0.0003 | |
| SRP193095 | EPG5 | 57724 | RNAseq | -1.0252 | 0.0000 | |
| SRP219564 | EPG5 | 57724 | RNAseq | -0.9700 | 0.0124 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by EPG5 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of EPG5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPG5 | 57724 | 1 | 8 | 21 | |
| GSE20123 | EPG5 | 57724 | 1 | 8 | 21 | |
| GSE43470 | EPG5 | 57724 | 0 | 4 | 39 | |
| GSE46452 | EPG5 | 57724 | 1 | 26 | 32 | |
| GSE47630 | EPG5 | 57724 | 5 | 20 | 15 | |
| GSE54993 | EPG5 | 57724 | 8 | 1 | 61 | |
| GSE54994 | EPG5 | 57724 | 2 | 15 | 36 | |
| GSE60625 | EPG5 | 57724 | 0 | 4 | 7 | |
| GSE74703 | EPG5 | 57724 | 0 | 3 | 33 | |
| GSE74704 | EPG5 | 57724 | 0 | 6 | 14 | |
| TCGA | EPG5 | 57724 | 14 | 39 | 43 |
Total number of gains: 32; Total number of losses: 134; Total Number of normals: 322.
Somatic mutations of EPG5:
Generating mutation plots.
Highly correlated genes for EPG5:
Showing top 20/1203 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPG5 | LYSMD3 | 0.847681 | 4 | 0 | 4 |
| EPG5 | ZNF92 | 0.822581 | 3 | 0 | 3 |
| EPG5 | ATP6V1D | 0.811784 | 4 | 0 | 4 |
| EPG5 | CNST | 0.81148 | 4 | 0 | 4 |
| EPG5 | B3GNT2 | 0.805663 | 3 | 0 | 3 |
| EPG5 | STRN | 0.792544 | 4 | 0 | 4 |
| EPG5 | PDCD6IP | 0.790838 | 4 | 0 | 4 |
| EPG5 | SPTLC1 | 0.784757 | 4 | 0 | 4 |
| EPG5 | DDX52 | 0.782588 | 3 | 0 | 3 |
| EPG5 | TAB3 | 0.777223 | 5 | 0 | 5 |
| EPG5 | RAB18 | 0.776479 | 3 | 0 | 3 |
| EPG5 | FBXO42 | 0.773457 | 3 | 0 | 3 |
| EPG5 | USP9Y | 0.767456 | 3 | 0 | 3 |
| EPG5 | ABLIM2 | 0.761842 | 3 | 0 | 3 |
| EPG5 | SLK | 0.76122 | 4 | 0 | 4 |
| EPG5 | USP6NL | 0.758406 | 5 | 0 | 5 |
| EPG5 | COBLL1 | 0.751525 | 4 | 0 | 4 |
| EPG5 | STXBP5 | 0.75146 | 5 | 0 | 4 |
| EPG5 | BLZF1 | 0.750621 | 4 | 0 | 4 |
| EPG5 | CDK7 | 0.750055 | 3 | 0 | 3 |
For details and further investigation, click here
