| Full name: ERCC excision repair 6, chromatin remodeling factor | Alias Symbol: CSB|RAD26|ARMD5 | ||
| Type: protein-coding gene | Cytoband: 10q11.23 | ||
| Entrez ID: 2074 | HGNC ID: HGNC:3438 | Ensembl Gene: ENSG00000225830 | OMIM ID: 609413 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ERCC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERCC6 | 2074 | 230108_at | 0.0954 | 0.8571 | |
| GSE20347 | ERCC6 | 2074 | 207347_at | 0.1123 | 0.2310 | |
| GSE23400 | ERCC6 | 2074 | 207347_at | -0.0456 | 0.3194 | |
| GSE26886 | ERCC6 | 2074 | 230108_at | -0.5013 | 0.0039 | |
| GSE29001 | ERCC6 | 2074 | 207347_at | -0.0324 | 0.9032 | |
| GSE38129 | ERCC6 | 2074 | 207347_at | 0.0630 | 0.5204 | |
| GSE45670 | ERCC6 | 2074 | 230108_at | 0.1925 | 0.0969 | |
| GSE53622 | ERCC6 | 2074 | 36816 | -0.4934 | 0.0000 | |
| GSE53624 | ERCC6 | 2074 | 36816 | -0.2660 | 0.0135 | |
| GSE63941 | ERCC6 | 2074 | 230108_at | 0.4753 | 0.1882 | |
| GSE77861 | ERCC6 | 2074 | 230108_at | -0.1574 | 0.2100 | |
| GSE97050 | ERCC6 | 2074 | A_23_P1292 | 0.2914 | 0.3897 | |
| SRP007169 | ERCC6 | 2074 | RNAseq | -0.0084 | 0.9851 | |
| SRP008496 | ERCC6 | 2074 | RNAseq | 0.4013 | 0.2745 | |
| SRP064894 | ERCC6 | 2074 | RNAseq | -0.7029 | 0.0067 | |
| SRP133303 | ERCC6 | 2074 | RNAseq | -0.0345 | 0.8407 | |
| SRP159526 | ERCC6 | 2074 | RNAseq | -0.7126 | 0.0400 | |
| SRP193095 | ERCC6 | 2074 | RNAseq | -0.2172 | 0.0794 | |
| SRP219564 | ERCC6 | 2074 | RNAseq | -1.0191 | 0.0393 | |
| TCGA | ERCC6 | 2074 | RNAseq | 0.0599 | 0.4355 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ERCC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERCC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERCC6 | 2074 | 2 | 5 | 23 | |
| GSE20123 | ERCC6 | 2074 | 2 | 5 | 23 | |
| GSE43470 | ERCC6 | 2074 | 2 | 6 | 35 | |
| GSE46452 | ERCC6 | 2074 | 0 | 13 | 46 | |
| GSE47630 | ERCC6 | 2074 | 4 | 12 | 24 | |
| GSE54993 | ERCC6 | 2074 | 9 | 0 | 61 | |
| GSE54994 | ERCC6 | 2074 | 2 | 10 | 41 | |
| GSE60625 | ERCC6 | 2074 | 0 | 0 | 11 | |
| GSE74703 | ERCC6 | 2074 | 2 | 3 | 31 | |
| GSE74704 | ERCC6 | 2074 | 1 | 4 | 15 | |
| TCGA | ERCC6 | 2074 | 12 | 22 | 62 |
Total number of gains: 36; Total number of losses: 80; Total Number of normals: 372.
Somatic mutations of ERCC6:
Generating mutation plots.
Highly correlated genes for ERCC6:
Showing top 20/535 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERCC6 | LARP4 | 0.805844 | 3 | 0 | 3 |
| ERCC6 | ZNF616 | 0.787576 | 3 | 0 | 3 |
| ERCC6 | NANS | 0.783511 | 3 | 0 | 3 |
| ERCC6 | TBK1 | 0.781621 | 3 | 0 | 3 |
| ERCC6 | PRKCH | 0.775217 | 4 | 0 | 4 |
| ERCC6 | PDIK1L | 0.773646 | 4 | 0 | 4 |
| ERCC6 | MRPS18A | 0.772986 | 3 | 0 | 3 |
| ERCC6 | BROX | 0.772978 | 3 | 0 | 3 |
| ERCC6 | RASA2 | 0.765137 | 3 | 0 | 3 |
| ERCC6 | GLO1 | 0.758926 | 3 | 0 | 3 |
| ERCC6 | NECAP2 | 0.742669 | 3 | 0 | 3 |
| ERCC6 | GTF2A1 | 0.740613 | 4 | 0 | 3 |
| ERCC6 | ZNF41 | 0.73917 | 3 | 0 | 3 |
| ERCC6 | MBOAT1 | 0.728965 | 3 | 0 | 3 |
| ERCC6 | SRRM1 | 0.728469 | 3 | 0 | 3 |
| ERCC6 | ALDH5A1 | 0.728433 | 3 | 0 | 3 |
| ERCC6 | ZNF17 | 0.727446 | 4 | 0 | 4 |
| ERCC6 | ERI2 | 0.726089 | 3 | 0 | 3 |
| ERCC6 | DLG2 | 0.725815 | 3 | 0 | 3 |
| ERCC6 | FDXACB1 | 0.722935 | 4 | 0 | 3 |
For details and further investigation, click here
