| Full name: TAL bHLH transcription factor 1, erythroid differentiation factor | Alias Symbol: SCL|bHLHa17 | ||
| Type: protein-coding gene | Cytoband: 1p33 | ||
| Entrez ID: 6886 | HGNC ID: HGNC:11556 | Ensembl Gene: ENSG00000162367 | OMIM ID: 187040 |
| Drug and gene relationship at DGIdb | |||
Expression of TAL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAL1 | 6886 | 1561651_s_at | -0.2230 | 0.3506 | |
| GSE20347 | TAL1 | 6886 | 216925_s_at | -0.0336 | 0.8080 | |
| GSE23400 | TAL1 | 6886 | 216925_s_at | -0.1473 | 0.0029 | |
| GSE26886 | TAL1 | 6886 | 1561651_s_at | -0.0232 | 0.8632 | |
| GSE29001 | TAL1 | 6886 | 216925_s_at | 0.0203 | 0.9252 | |
| GSE38129 | TAL1 | 6886 | 216925_s_at | -0.1534 | 0.0901 | |
| GSE45670 | TAL1 | 6886 | 1561651_s_at | -0.2102 | 0.0725 | |
| GSE53622 | TAL1 | 6886 | 30491 | -0.9210 | 0.0000 | |
| GSE53624 | TAL1 | 6886 | 30491 | -0.7088 | 0.0000 | |
| GSE63941 | TAL1 | 6886 | 1561651_s_at | 0.2328 | 0.1722 | |
| GSE77861 | TAL1 | 6886 | 1561651_s_at | -0.2489 | 0.1088 | |
| GSE97050 | TAL1 | 6886 | A_23_P63371 | -0.0113 | 0.9729 | |
| SRP064894 | TAL1 | 6886 | RNAseq | 0.1026 | 0.7619 | |
| SRP133303 | TAL1 | 6886 | RNAseq | -0.6919 | 0.0003 | |
| SRP159526 | TAL1 | 6886 | RNAseq | 0.0118 | 0.9819 | |
| SRP193095 | TAL1 | 6886 | RNAseq | 0.1592 | 0.2766 | |
| SRP219564 | TAL1 | 6886 | RNAseq | 0.2861 | 0.5772 | |
| TCGA | TAL1 | 6886 | RNAseq | -1.0331 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TAL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TAL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAL1 | 6886 | 4 | 3 | 23 | |
| GSE20123 | TAL1 | 6886 | 4 | 2 | 24 | |
| GSE43470 | TAL1 | 6886 | 5 | 1 | 37 | |
| GSE46452 | TAL1 | 6886 | 2 | 1 | 56 | |
| GSE47630 | TAL1 | 6886 | 8 | 4 | 28 | |
| GSE54993 | TAL1 | 6886 | 0 | 1 | 69 | |
| GSE54994 | TAL1 | 6886 | 11 | 2 | 40 | |
| GSE60625 | TAL1 | 6886 | 0 | 0 | 11 | |
| GSE74703 | TAL1 | 6886 | 4 | 1 | 31 | |
| GSE74704 | TAL1 | 6886 | 2 | 0 | 18 | |
| TCGA | TAL1 | 6886 | 10 | 17 | 69 |
Total number of gains: 50; Total number of losses: 32; Total Number of normals: 406.
Somatic mutations of TAL1:
Generating mutation plots.
Highly correlated genes for TAL1:
Showing top 20/935 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAL1 | CACFD1 | 0.726186 | 5 | 0 | 5 |
| TAL1 | GYPB | 0.725475 | 4 | 0 | 4 |
| TAL1 | DGKA | 0.709314 | 3 | 0 | 3 |
| TAL1 | FSHR | 0.707239 | 5 | 0 | 5 |
| TAL1 | LUZP4 | 0.706973 | 5 | 0 | 5 |
| TAL1 | GALNT8 | 0.705511 | 5 | 0 | 5 |
| TAL1 | KRTAP4-7 | 0.690475 | 5 | 0 | 5 |
| TAL1 | PF4 | 0.687804 | 4 | 0 | 4 |
| TAL1 | IFNA17 | 0.686978 | 5 | 0 | 4 |
| TAL1 | FAM66D | 0.682177 | 5 | 0 | 5 |
| TAL1 | SLC17A3 | 0.678858 | 6 | 0 | 5 |
| TAL1 | SLC2A5 | 0.674332 | 3 | 0 | 3 |
| TAL1 | SCN8A | 0.674168 | 5 | 0 | 5 |
| TAL1 | MTAP | 0.672714 | 6 | 0 | 5 |
| TAL1 | STX11 | 0.671677 | 3 | 0 | 3 |
| TAL1 | OR7E24 | 0.670866 | 6 | 0 | 6 |
| TAL1 | NR1H4 | 0.665636 | 4 | 0 | 4 |
| TAL1 | ASCL3 | 0.665103 | 6 | 0 | 6 |
| TAL1 | DCC | 0.662777 | 5 | 0 | 5 |
| TAL1 | NEUROD2 | 0.661684 | 4 | 0 | 3 |
For details and further investigation, click here
