| Full name: diacylglycerol kinase alpha | Alias Symbol: DGK-alpha | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 1606 | HGNC ID: HGNC:2849 | Ensembl Gene: ENSG00000065357 | OMIM ID: 125855 |
| Drug and gene relationship at DGIdb | |||
Expression of DGKA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGKA | 1606 | 203385_at | -0.3382 | 0.5832 | |
| GSE20347 | DGKA | 1606 | 203385_at | -0.8528 | 0.0000 | |
| GSE23400 | DGKA | 1606 | 203385_at | -0.6051 | 0.0000 | |
| GSE26886 | DGKA | 1606 | 203385_at | -1.4299 | 0.0000 | |
| GSE29001 | DGKA | 1606 | 203385_at | -1.1206 | 0.0022 | |
| GSE38129 | DGKA | 1606 | 203385_at | -0.3635 | 0.2039 | |
| GSE45670 | DGKA | 1606 | 203385_at | -0.3180 | 0.1061 | |
| GSE53622 | DGKA | 1606 | 52125 | -0.7377 | 0.0000 | |
| GSE53624 | DGKA | 1606 | 52125 | -0.9487 | 0.0000 | |
| GSE63941 | DGKA | 1606 | 203385_at | 1.8713 | 0.0009 | |
| GSE77861 | DGKA | 1606 | 203385_at | -0.3385 | 0.2665 | |
| GSE97050 | DGKA | 1606 | A_23_P105307 | -0.1291 | 0.8428 | |
| SRP007169 | DGKA | 1606 | RNAseq | -1.6420 | 0.0000 | |
| SRP008496 | DGKA | 1606 | RNAseq | -2.0045 | 0.0000 | |
| SRP064894 | DGKA | 1606 | RNAseq | -0.9451 | 0.0000 | |
| SRP133303 | DGKA | 1606 | RNAseq | -0.5921 | 0.0091 | |
| SRP159526 | DGKA | 1606 | RNAseq | -1.2772 | 0.0000 | |
| SRP193095 | DGKA | 1606 | RNAseq | -0.7673 | 0.0001 | |
| SRP219564 | DGKA | 1606 | RNAseq | -0.9847 | 0.1087 | |
| TCGA | DGKA | 1606 | RNAseq | 0.3816 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by DGKA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGKA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGKA | 1606 | 6 | 2 | 22 | |
| GSE20123 | DGKA | 1606 | 6 | 1 | 23 | |
| GSE43470 | DGKA | 1606 | 4 | 0 | 39 | |
| GSE46452 | DGKA | 1606 | 8 | 1 | 50 | |
| GSE47630 | DGKA | 1606 | 10 | 2 | 28 | |
| GSE54993 | DGKA | 1606 | 0 | 5 | 65 | |
| GSE54994 | DGKA | 1606 | 4 | 1 | 48 | |
| GSE60625 | DGKA | 1606 | 0 | 0 | 11 | |
| GSE74703 | DGKA | 1606 | 4 | 0 | 32 | |
| GSE74704 | DGKA | 1606 | 4 | 1 | 15 | |
| TCGA | DGKA | 1606 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of DGKA:
Generating mutation plots.
Highly correlated genes for DGKA:
Showing top 20/1345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGKA | EPGN | 0.809556 | 3 | 0 | 3 |
| DGKA | NIPAL1 | 0.805661 | 3 | 0 | 3 |
| DGKA | EVPL | 0.778635 | 12 | 0 | 11 |
| DGKA | SYTL1 | 0.774183 | 9 | 0 | 9 |
| DGKA | C6orf132 | 0.7705 | 7 | 0 | 7 |
| DGKA | SH3GL1 | 0.767922 | 11 | 0 | 11 |
| DGKA | ARHGAP32 | 0.763601 | 10 | 0 | 10 |
| DGKA | KIF21A | 0.759857 | 5 | 0 | 5 |
| DGKA | EPS8L2 | 0.75794 | 10 | 0 | 10 |
| DGKA | CAPN1 | 0.7538 | 13 | 0 | 13 |
| DGKA | ALS2CL | 0.751497 | 11 | 0 | 11 |
| DGKA | PPP1R13L | 0.751006 | 12 | 0 | 11 |
| DGKA | EXPH5 | 0.75065 | 11 | 0 | 11 |
| DGKA | DUOX1 | 0.741962 | 13 | 0 | 12 |
| DGKA | RAB25 | 0.741183 | 13 | 0 | 12 |
| DGKA | TECR | 0.740641 | 12 | 0 | 12 |
| DGKA | MPZL3 | 0.737817 | 7 | 0 | 7 |
| DGKA | EPHA1 | 0.736278 | 12 | 0 | 12 |
| DGKA | FRMD4B | 0.733521 | 11 | 0 | 11 |
| DGKA | ARHGAP27 | 0.731587 | 9 | 0 | 8 |
For details and further investigation, click here
