| Full name: follicle stimulating hormone receptor | Alias Symbol: FSHRO|LGR1 | ||
| Type: protein-coding gene | Cytoband: 2p16.3 | ||
| Entrez ID: 2492 | HGNC ID: HGNC:3969 | Ensembl Gene: ENSG00000170820 | OMIM ID: 136435 |
| Drug and gene relationship at DGIdb | |||
FSHR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04913 | Ovarian steroidogenesis |
Expression of FSHR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FSHR | 2492 | 211201_at | -0.0423 | 0.8819 | |
| GSE20347 | FSHR | 2492 | 211201_at | -0.0577 | 0.4765 | |
| GSE23400 | FSHR | 2492 | 211201_at | -0.1363 | 0.0007 | |
| GSE26886 | FSHR | 2492 | 211201_at | -0.1392 | 0.1579 | |
| GSE29001 | FSHR | 2492 | 211201_at | -0.2011 | 0.1835 | |
| GSE38129 | FSHR | 2492 | 211201_at | -0.1625 | 0.0361 | |
| GSE45670 | FSHR | 2492 | 211201_at | 0.0385 | 0.7500 | |
| GSE53622 | FSHR | 2492 | 64707 | -1.0805 | 0.0000 | |
| GSE53624 | FSHR | 2492 | 64707 | -1.5783 | 0.0000 | |
| GSE63941 | FSHR | 2492 | 211201_at | -0.0122 | 0.9424 | |
| GSE77861 | FSHR | 2492 | 211201_at | -0.2145 | 0.0864 | |
| TCGA | FSHR | 2492 | RNAseq | -2.1588 | 0.3794 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FSHR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FSHR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FSHR | 2492 | 6 | 2 | 22 | |
| GSE20123 | FSHR | 2492 | 6 | 1 | 23 | |
| GSE43470 | FSHR | 2492 | 5 | 0 | 38 | |
| GSE46452 | FSHR | 2492 | 1 | 4 | 54 | |
| GSE47630 | FSHR | 2492 | 8 | 0 | 32 | |
| GSE54993 | FSHR | 2492 | 0 | 5 | 65 | |
| GSE54994 | FSHR | 2492 | 12 | 0 | 41 | |
| GSE60625 | FSHR | 2492 | 0 | 3 | 8 | |
| GSE74703 | FSHR | 2492 | 5 | 0 | 31 | |
| GSE74704 | FSHR | 2492 | 7 | 1 | 12 | |
| TCGA | FSHR | 2492 | 36 | 2 | 58 |
Total number of gains: 86; Total number of losses: 18; Total Number of normals: 384.
Somatic mutations of FSHR:
Generating mutation plots.
Highly correlated genes for FSHR:
Showing top 20/1067 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FSHR | HAMP | 0.804002 | 3 | 0 | 3 |
| FSHR | CGA | 0.744178 | 4 | 0 | 4 |
| FSHR | IFNA4 | 0.728901 | 4 | 0 | 4 |
| FSHR | HCG27 | 0.716273 | 4 | 0 | 3 |
| FSHR | GPLD1 | 0.707264 | 3 | 0 | 3 |
| FSHR | TAL1 | 0.707239 | 5 | 0 | 5 |
| FSHR | SLC2A5 | 0.705154 | 3 | 0 | 3 |
| FSHR | OR3A3 | 0.705142 | 4 | 0 | 4 |
| FSHR | DEFA4 | 0.700475 | 3 | 0 | 3 |
| FSHR | CTNNBIP1 | 0.700375 | 4 | 0 | 4 |
| FSHR | CYP2A6 | 0.699904 | 4 | 0 | 4 |
| FSHR | LIMD1 | 0.698024 | 3 | 0 | 3 |
| FSHR | IFNA17 | 0.696235 | 6 | 0 | 6 |
| FSHR | HAND1 | 0.694518 | 7 | 0 | 7 |
| FSHR | ZNF717 | 0.692982 | 5 | 0 | 4 |
| FSHR | IVL | 0.688984 | 5 | 0 | 4 |
| FSHR | PRPH2 | 0.688356 | 4 | 0 | 4 |
| FSHR | FCN2 | 0.687979 | 3 | 0 | 3 |
| FSHR | PRR34 | 0.687309 | 5 | 0 | 5 |
| FSHR | KHDRBS2 | 0.686858 | 4 | 0 | 4 |
For details and further investigation, click here
