| Full name: nuclear receptor subfamily 1 group H member 4 | Alias Symbol: FXR|RIP14|HRR1|HRR-1 | ||
| Type: protein-coding gene | Cytoband: 12q23.1 | ||
| Entrez ID: 9971 | HGNC ID: HGNC:7967 | Ensembl Gene: ENSG00000012504 | OMIM ID: 603826 |
| Drug and gene relationship at DGIdb | |||
NR1H4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of NR1H4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NR1H4 | 9971 | 206340_at | 0.0428 | 0.8501 | |
| GSE20347 | NR1H4 | 9971 | 206340_at | -0.0982 | 0.1288 | |
| GSE23400 | NR1H4 | 9971 | 206340_at | -0.1452 | 0.0000 | |
| GSE26886 | NR1H4 | 9971 | 206340_at | -0.0303 | 0.7778 | |
| GSE29001 | NR1H4 | 9971 | 206340_at | -0.0545 | 0.7717 | |
| GSE38129 | NR1H4 | 9971 | 206340_at | -0.1638 | 0.0046 | |
| GSE45670 | NR1H4 | 9971 | 1554375_a_at | -0.0900 | 0.3826 | |
| GSE53622 | NR1H4 | 9971 | 45701 | -0.0133 | 0.9198 | |
| GSE53624 | NR1H4 | 9971 | 45701 | -0.1760 | 0.3876 | |
| GSE63941 | NR1H4 | 9971 | 206340_at | 0.0598 | 0.6542 | |
| GSE77861 | NR1H4 | 9971 | 206340_at | -0.0080 | 0.9341 | |
| SRP133303 | NR1H4 | 9971 | RNAseq | -1.2814 | 0.0000 | |
| TCGA | NR1H4 | 9971 | RNAseq | -2.3007 | 0.0618 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NR1H4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NR1H4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NR1H4 | 9971 | 2 | 2 | 26 | |
| GSE20123 | NR1H4 | 9971 | 2 | 2 | 26 | |
| GSE43470 | NR1H4 | 9971 | 2 | 0 | 41 | |
| GSE46452 | NR1H4 | 9971 | 9 | 1 | 49 | |
| GSE47630 | NR1H4 | 9971 | 9 | 1 | 30 | |
| GSE54993 | NR1H4 | 9971 | 0 | 5 | 65 | |
| GSE54994 | NR1H4 | 9971 | 4 | 2 | 47 | |
| GSE60625 | NR1H4 | 9971 | 0 | 0 | 11 | |
| GSE74703 | NR1H4 | 9971 | 2 | 0 | 34 | |
| GSE74704 | NR1H4 | 9971 | 1 | 2 | 17 | |
| TCGA | NR1H4 | 9971 | 19 | 10 | 67 |
Total number of gains: 50; Total number of losses: 25; Total Number of normals: 413.
Somatic mutations of NR1H4:
Generating mutation plots.
Highly correlated genes for NR1H4:
Showing top 20/517 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NR1H4 | MATN1 | 0.708444 | 3 | 0 | 3 |
| NR1H4 | CXorf38 | 0.693202 | 3 | 0 | 3 |
| NR1H4 | SSTR4 | 0.687837 | 4 | 0 | 4 |
| NR1H4 | CNR2 | 0.687581 | 4 | 0 | 4 |
| NR1H4 | DPEP1 | 0.682861 | 4 | 0 | 4 |
| NR1H4 | FGF23 | 0.681795 | 4 | 0 | 4 |
| NR1H4 | PHLDB1 | 0.67621 | 5 | 0 | 4 |
| NR1H4 | INO80D | 0.676145 | 4 | 0 | 4 |
| NR1H4 | OR1D2 | 0.67599 | 4 | 0 | 4 |
| NR1H4 | A4GNT | 0.671907 | 4 | 0 | 4 |
| NR1H4 | PTK2B | 0.669404 | 3 | 0 | 3 |
| NR1H4 | CYP2D6 | 0.667036 | 5 | 0 | 5 |
| NR1H4 | BTNL3 | 0.666338 | 4 | 0 | 4 |
| NR1H4 | TAL1 | 0.665636 | 4 | 0 | 4 |
| NR1H4 | C11orf16 | 0.664326 | 4 | 0 | 4 |
| NR1H4 | IRS4 | 0.663628 | 4 | 0 | 4 |
| NR1H4 | SERPINA4 | 0.661491 | 4 | 0 | 3 |
| NR1H4 | CRB1 | 0.661402 | 5 | 0 | 5 |
| NR1H4 | SHBG | 0.657244 | 4 | 0 | 4 |
| NR1H4 | ZNF280A | 0.654123 | 3 | 0 | 3 |
For details and further investigation, click here
