| Full name: alpha fetoprotein | Alias Symbol: FETA | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 174 | HGNC ID: HGNC:317 | Ensembl Gene: ENSG00000081051 | OMIM ID: 104150 |
| Drug and gene relationship at DGIdb | |||
AFP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of AFP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFP | 174 | 204694_at | 0.0422 | 0.8807 | |
| GSE20347 | AFP | 174 | 204694_at | 0.0465 | 0.4002 | |
| GSE23400 | AFP | 174 | 204694_at | -0.0261 | 0.3709 | |
| GSE26886 | AFP | 174 | 204694_at | 0.1920 | 0.0715 | |
| GSE29001 | AFP | 174 | 204694_at | 0.0547 | 0.7458 | |
| GSE38129 | AFP | 174 | 204694_at | 0.1663 | 0.1769 | |
| GSE45670 | AFP | 174 | 204694_at | 0.0882 | 0.4407 | |
| GSE53622 | AFP | 174 | 122557 | 0.5034 | 0.0056 | |
| GSE53624 | AFP | 174 | 122557 | 1.2268 | 0.0000 | |
| GSE63941 | AFP | 174 | 204694_at | -0.9924 | 0.0423 | |
| GSE77861 | AFP | 174 | 204694_at | -0.0802 | 0.4096 | |
| TCGA | AFP | 174 | RNAseq | 3.1391 | 0.0301 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AFP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AFP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFP | 174 | 2 | 9 | 19 | |
| GSE20123 | AFP | 174 | 2 | 9 | 19 | |
| GSE43470 | AFP | 174 | 0 | 13 | 30 | |
| GSE46452 | AFP | 174 | 3 | 34 | 22 | |
| GSE47630 | AFP | 174 | 1 | 19 | 20 | |
| GSE54993 | AFP | 174 | 7 | 0 | 63 | |
| GSE54994 | AFP | 174 | 1 | 9 | 43 | |
| GSE60625 | AFP | 174 | 0 | 0 | 11 | |
| GSE74703 | AFP | 174 | 0 | 11 | 25 | |
| GSE74704 | AFP | 174 | 2 | 5 | 13 | |
| TCGA | AFP | 174 | 19 | 27 | 50 |
Total number of gains: 37; Total number of losses: 136; Total Number of normals: 315.
Somatic mutations of AFP:
Generating mutation plots.
Highly correlated genes for AFP:
Showing top 20/191 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFP | ZP2 | 0.736538 | 3 | 0 | 3 |
| AFP | ADAM21 | 0.708776 | 3 | 0 | 3 |
| AFP | ITIH1 | 0.699598 | 3 | 0 | 3 |
| AFP | NPTXR | 0.697208 | 4 | 0 | 4 |
| AFP | TBX4 | 0.69453 | 3 | 0 | 3 |
| AFP | FAM153A | 0.687556 | 3 | 0 | 3 |
| AFP | MIRLET7BHG | 0.686068 | 3 | 0 | 3 |
| AFP | CYP2W1 | 0.678234 | 4 | 0 | 4 |
| AFP | NCR3 | 0.671993 | 3 | 0 | 3 |
| AFP | PKLR | 0.671881 | 5 | 0 | 4 |
| AFP | CACNG2 | 0.667701 | 4 | 0 | 4 |
| AFP | PRSS12 | 0.666261 | 3 | 0 | 3 |
| AFP | SPATA9 | 0.665464 | 3 | 0 | 3 |
| AFP | EIF1AY | 0.658731 | 3 | 0 | 3 |
| AFP | CCL1 | 0.656713 | 3 | 0 | 3 |
| AFP | FGG | 0.656417 | 4 | 0 | 3 |
| AFP | DNM3 | 0.65547 | 3 | 0 | 3 |
| AFP | TNXB | 0.654346 | 4 | 0 | 4 |
| AFP | TRHDE | 0.654272 | 3 | 0 | 3 |
| AFP | VPS9D1 | 0.651858 | 4 | 0 | 4 |
For details and further investigation, click here
