| Full name: T-box transcription factor 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 6911 | HGNC ID: HGNC:11605 | Ensembl Gene: ENSG00000149922 | OMIM ID: 602427 |
| Drug and gene relationship at DGIdb | |||
Expression of TBX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBX6 | 6911 | 207684_at | -0.0896 | 0.7341 | |
| GSE20347 | TBX6 | 6911 | 207684_at | -0.1237 | 0.2149 | |
| GSE23400 | TBX6 | 6911 | 207684_at | -0.2762 | 0.0000 | |
| GSE26886 | TBX6 | 6911 | 215122_at | -0.1867 | 0.1454 | |
| GSE29001 | TBX6 | 6911 | 207684_at | -0.2601 | 0.0797 | |
| GSE38129 | TBX6 | 6911 | 207684_at | -0.2247 | 0.0346 | |
| GSE45670 | TBX6 | 6911 | 215122_at | 0.0459 | 0.7479 | |
| GSE53622 | TBX6 | 6911 | 21307 | -0.8034 | 0.0000 | |
| GSE53624 | TBX6 | 6911 | 21307 | -0.5292 | 0.0000 | |
| GSE63941 | TBX6 | 6911 | 207684_at | 0.1131 | 0.5046 | |
| GSE77861 | TBX6 | 6911 | 207684_at | -0.2087 | 0.1329 | |
| GSE97050 | TBX6 | 6911 | A_24_P167970 | 0.1991 | 0.4106 | |
| SRP007169 | TBX6 | 6911 | RNAseq | -1.5898 | 0.0964 | |
| SRP008496 | TBX6 | 6911 | RNAseq | -2.3812 | 0.0082 | |
| SRP064894 | TBX6 | 6911 | RNAseq | -1.5710 | 0.0000 | |
| SRP133303 | TBX6 | 6911 | RNAseq | -1.8023 | 0.0000 | |
| SRP159526 | TBX6 | 6911 | RNAseq | -2.0272 | 0.0000 | |
| SRP193095 | TBX6 | 6911 | RNAseq | -1.5429 | 0.0000 | |
| SRP219564 | TBX6 | 6911 | RNAseq | -1.3664 | 0.0252 | |
| TCGA | TBX6 | 6911 | RNAseq | 0.1200 | 0.5683 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by TBX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBX6 | 6911 | 5 | 5 | 20 | |
| GSE20123 | TBX6 | 6911 | 5 | 4 | 21 | |
| GSE43470 | TBX6 | 6911 | 3 | 3 | 37 | |
| GSE46452 | TBX6 | 6911 | 38 | 1 | 20 | |
| GSE47630 | TBX6 | 6911 | 11 | 7 | 22 | |
| GSE54993 | TBX6 | 6911 | 2 | 5 | 63 | |
| GSE54994 | TBX6 | 6911 | 5 | 9 | 39 | |
| GSE60625 | TBX6 | 6911 | 4 | 0 | 7 | |
| GSE74703 | TBX6 | 6911 | 3 | 2 | 31 | |
| GSE74704 | TBX6 | 6911 | 3 | 2 | 15 | |
| TCGA | TBX6 | 6911 | 20 | 11 | 65 |
Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.
Somatic mutations of TBX6:
Generating mutation plots.
Highly correlated genes for TBX6:
Showing top 20/961 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBX6 | SCNN1G | 0.6977 | 5 | 0 | 5 |
| TBX6 | ZNF335 | 0.691078 | 3 | 0 | 3 |
| TBX6 | STX1B | 0.683719 | 3 | 0 | 3 |
| TBX6 | LZTS1 | 0.683191 | 3 | 0 | 3 |
| TBX6 | IFNA10 | 0.68082 | 5 | 0 | 4 |
| TBX6 | CITED1 | 0.680635 | 3 | 0 | 3 |
| TBX6 | SERPINA6 | 0.673417 | 4 | 0 | 4 |
| TBX6 | CD5 | 0.673163 | 5 | 0 | 4 |
| TBX6 | IL1RAPL2 | 0.672675 | 4 | 0 | 4 |
| TBX6 | MYOG | 0.665485 | 6 | 0 | 5 |
| TBX6 | IHH | 0.661377 | 5 | 0 | 5 |
| TBX6 | CIDEB | 0.656243 | 6 | 0 | 5 |
| TBX6 | C11orf16 | 0.653157 | 7 | 0 | 5 |
| TBX6 | IL9R | 0.652902 | 6 | 0 | 5 |
| TBX6 | HRH2 | 0.652864 | 5 | 0 | 4 |
| TBX6 | PDZD7 | 0.652421 | 6 | 0 | 6 |
| TBX6 | RGSL1 | 0.650258 | 5 | 0 | 5 |
| TBX6 | GABRA4 | 0.649669 | 5 | 0 | 5 |
| TBX6 | GJA8 | 0.648932 | 7 | 0 | 6 |
| TBX6 | KRTAP5-8 | 0.648602 | 5 | 0 | 5 |
For details and further investigation, click here
