| Full name: gamma-aminobutyric acid type A receptor alpha4 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p12 | ||
| Entrez ID: 2557 | HGNC ID: HGNC:4078 | Ensembl Gene: ENSG00000109158 | OMIM ID: 137141 |
| Drug and gene relationship at DGIdb | |||
GABRA4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa04742 | Taste transduction | |
| hsa05032 | Morphine addiction |
Expression of GABRA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRA4 | 2557 | 233437_at | -0.1687 | 0.4530 | |
| GSE20347 | GABRA4 | 2557 | 208463_at | -0.1570 | 0.0500 | |
| GSE23400 | GABRA4 | 2557 | 208463_at | -0.1840 | 0.0007 | |
| GSE26886 | GABRA4 | 2557 | 208463_at | -0.7873 | 0.0007 | |
| GSE29001 | GABRA4 | 2557 | 208463_at | -0.4781 | 0.0057 | |
| GSE38129 | GABRA4 | 2557 | 208463_at | -0.2088 | 0.0164 | |
| GSE45670 | GABRA4 | 2557 | 208463_at | -0.1203 | 0.3131 | |
| GSE53622 | GABRA4 | 2557 | 51075 | -0.4266 | 0.0015 | |
| GSE53624 | GABRA4 | 2557 | 51075 | -1.1486 | 0.0000 | |
| GSE63941 | GABRA4 | 2557 | 208463_at | -0.0276 | 0.8447 | |
| GSE77861 | GABRA4 | 2557 | 208463_at | -0.2067 | 0.1232 | |
| SRP133303 | GABRA4 | 2557 | RNAseq | -0.7839 | 0.0063 | |
| SRP159526 | GABRA4 | 2557 | RNAseq | -1.7179 | 0.0066 | |
| SRP193095 | GABRA4 | 2557 | RNAseq | -1.8582 | 0.0000 | |
| TCGA | GABRA4 | 2557 | RNAseq | -1.3414 | 0.2140 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by GABRA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRA4 | 2557 | 1 | 15 | 14 | |
| GSE20123 | GABRA4 | 2557 | 1 | 15 | 14 | |
| GSE43470 | GABRA4 | 2557 | 0 | 14 | 29 | |
| GSE46452 | GABRA4 | 2557 | 1 | 37 | 21 | |
| GSE47630 | GABRA4 | 2557 | 1 | 18 | 21 | |
| GSE54993 | GABRA4 | 2557 | 7 | 0 | 63 | |
| GSE54994 | GABRA4 | 2557 | 4 | 9 | 40 | |
| GSE60625 | GABRA4 | 2557 | 0 | 0 | 11 | |
| GSE74703 | GABRA4 | 2557 | 0 | 12 | 24 | |
| GSE74704 | GABRA4 | 2557 | 0 | 9 | 11 | |
| TCGA | GABRA4 | 2557 | 15 | 33 | 48 |
Total number of gains: 30; Total number of losses: 162; Total Number of normals: 296.
Somatic mutations of GABRA4:
Generating mutation plots.
Highly correlated genes for GABRA4:
Showing top 20/618 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRA4 | AMHR2 | 0.704479 | 4 | 0 | 4 |
| GABRA4 | SLC28A2 | 0.692296 | 5 | 0 | 5 |
| GABRA4 | NPAP1 | 0.691503 | 4 | 0 | 4 |
| GABRA4 | SLC25A51 | 0.69021 | 3 | 0 | 3 |
| GABRA4 | INO80D | 0.682212 | 5 | 0 | 4 |
| GABRA4 | GATA1 | 0.680007 | 3 | 0 | 3 |
| GABRA4 | HHLA1 | 0.679863 | 4 | 0 | 4 |
| GABRA4 | GJB4 | 0.672894 | 5 | 0 | 4 |
| GABRA4 | SCNN1G | 0.665527 | 6 | 0 | 6 |
| GABRA4 | EPS8L3 | 0.665355 | 5 | 0 | 5 |
| GABRA4 | MASP1 | 0.664943 | 5 | 0 | 4 |
| GABRA4 | MATN1 | 0.659507 | 3 | 0 | 3 |
| GABRA4 | EPOR | 0.65884 | 6 | 0 | 6 |
| GABRA4 | CDC14A | 0.65858 | 5 | 0 | 5 |
| GABRA4 | APBA1 | 0.652642 | 4 | 0 | 4 |
| GABRA4 | TBX6 | 0.649669 | 5 | 0 | 5 |
| GABRA4 | CHRM2 | 0.648863 | 4 | 0 | 4 |
| GABRA4 | CAV3 | 0.648086 | 6 | 0 | 5 |
| GABRA4 | UPK2 | 0.647874 | 6 | 0 | 6 |
| GABRA4 | ZFP36 | 0.647814 | 3 | 0 | 3 |
For details and further investigation, click here
