| Full name: Indian hedgehog signaling molecule | Alias Symbol: HHG2|BDA1 | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 3549 | HGNC ID: HGNC:5956 | Ensembl Gene: ENSG00000163501 | OMIM ID: 600726 |
| Drug and gene relationship at DGIdb | |||
IHH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of IHH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IHH | 3549 | 215420_at | 0.0138 | 0.9697 | |
| GSE20347 | IHH | 3549 | 215420_at | -0.1153 | 0.1700 | |
| GSE23400 | IHH | 3549 | 215420_at | -0.1487 | 0.0000 | |
| GSE26886 | IHH | 3549 | 229358_at | 0.1072 | 0.3595 | |
| GSE29001 | IHH | 3549 | 215420_at | -0.2548 | 0.1746 | |
| GSE38129 | IHH | 3549 | 215420_at | -0.1704 | 0.1732 | |
| GSE45670 | IHH | 3549 | 215420_at | -0.0792 | 0.2969 | |
| GSE53622 | IHH | 3549 | 88345 | 0.0277 | 0.8852 | |
| GSE53624 | IHH | 3549 | 88345 | -0.5782 | 0.0000 | |
| GSE63941 | IHH | 3549 | 229358_at | 0.1682 | 0.3203 | |
| GSE77861 | IHH | 3549 | 215420_at | -0.1293 | 0.2374 | |
| TCGA | IHH | 3549 | RNAseq | -4.9803 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by IHH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IHH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IHH | 3549 | 1 | 14 | 15 | |
| GSE20123 | IHH | 3549 | 1 | 13 | 16 | |
| GSE43470 | IHH | 3549 | 1 | 7 | 35 | |
| GSE46452 | IHH | 3549 | 0 | 5 | 54 | |
| GSE47630 | IHH | 3549 | 4 | 5 | 31 | |
| GSE54993 | IHH | 3549 | 1 | 2 | 67 | |
| GSE54994 | IHH | 3549 | 7 | 10 | 36 | |
| GSE60625 | IHH | 3549 | 0 | 3 | 8 | |
| GSE74703 | IHH | 3549 | 1 | 5 | 30 | |
| GSE74704 | IHH | 3549 | 1 | 7 | 12 | |
| TCGA | IHH | 3549 | 11 | 27 | 58 |
Total number of gains: 28; Total number of losses: 98; Total Number of normals: 362.
Somatic mutations of IHH:
Generating mutation plots.
Highly correlated genes for IHH:
Showing top 20/1017 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IHH | EDA2R | 0.764602 | 5 | 0 | 5 |
| IHH | IFNA21 | 0.743558 | 4 | 0 | 4 |
| IHH | BRINP2 | 0.720526 | 4 | 0 | 4 |
| IHH | CGA | 0.712249 | 5 | 0 | 5 |
| IHH | PAPPA2 | 0.699461 | 5 | 0 | 5 |
| IHH | CHST4 | 0.698776 | 4 | 0 | 4 |
| IHH | SLC10A1 | 0.698646 | 4 | 0 | 4 |
| IHH | ABCA4 | 0.691467 | 3 | 0 | 3 |
| IHH | KIR2DS5 | 0.68827 | 5 | 0 | 5 |
| IHH | GCM1 | 0.684963 | 3 | 0 | 3 |
| IHH | FMNL1 | 0.684881 | 3 | 0 | 3 |
| IHH | SLC6A5 | 0.684077 | 4 | 0 | 4 |
| IHH | GABRR2 | 0.683164 | 5 | 0 | 4 |
| IHH | KRT76 | 0.682548 | 4 | 0 | 4 |
| IHH | TTC36 | 0.681292 | 3 | 0 | 3 |
| IHH | EPOR | 0.677584 | 6 | 0 | 5 |
| IHH | SYT2 | 0.676544 | 4 | 0 | 4 |
| IHH | JAK3 | 0.674786 | 5 | 0 | 5 |
| IHH | MAGEA8 | 0.674779 | 3 | 0 | 3 |
| IHH | KIR2DS3 | 0.672697 | 5 | 0 | 5 |
For details and further investigation, click here
