DOCK5

 

Full name: dedicator of cytokinesis 5 Alias Symbol: FLJ21034
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 80005 HGNC ID: HGNC:23476 Ensembl Gene: ENSG00000147459 OMIM ID: 616904
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DOCK5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DOCK5 80005 230263_s_at 0.0830 0.9412
GSE20347 DOCK5 80005 219921_s_at 0.3394 0.0003
GSE23400 DOCK5 80005 219921_s_at 0.1483 0.0001
GSE26886 DOCK5 80005 230206_at 0.4582 0.3100
GSE29001 DOCK5 80005 219921_s_at 0.2646 0.1890
GSE38129 DOCK5 80005 219921_s_at 0.1030 0.2586
GSE45670 DOCK5 80005 230263_s_at -0.0359 0.9191
GSE53622 DOCK5 80005 88407 0.3189 0.0066
GSE53624 DOCK5 80005 16862 0.4603 0.0000
GSE63941 DOCK5 80005 230263_s_at 0.3982 0.6002
GSE77861 DOCK5 80005 1570078_a_at 0.2137 0.4965
GSE97050 DOCK5 80005 A_24_P350245 0.3704 0.3485
SRP007169 DOCK5 80005 RNAseq 0.9872 0.0502
SRP008496 DOCK5 80005 RNAseq 1.1441 0.0027
SRP064894 DOCK5 80005 RNAseq 0.4921 0.1043
SRP133303 DOCK5 80005 RNAseq 0.3617 0.0080
SRP159526 DOCK5 80005 RNAseq 0.3304 0.4645
SRP193095 DOCK5 80005 RNAseq 0.2019 0.1952
SRP219564 DOCK5 80005 RNAseq 0.1844 0.5757
TCGA DOCK5 80005 RNAseq -0.2156 0.0274

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DOCK5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DOCK5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DOCK5 80005 4 12 14
GSE20123 DOCK5 80005 4 12 14
GSE43470 DOCK5 80005 4 7 32
GSE46452 DOCK5 80005 13 13 33
GSE47630 DOCK5 80005 10 8 22
GSE54993 DOCK5 80005 2 15 53
GSE54994 DOCK5 80005 9 16 28
GSE60625 DOCK5 80005 3 0 8
GSE74703 DOCK5 80005 4 6 26
GSE74704 DOCK5 80005 3 8 9
TCGA DOCK5 80005 16 43 37

Total number of gains: 72; Total number of losses: 140; Total Number of normals: 276.  

 

Somatic mutations of DOCK5:

 

Generating mutation plots.

 

Highly correlated genes for DOCK5:

 

Showing top 20/330 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DOCK5PEG100.847674303
DOCK5FAU0.813982303
DOCK5MRPL490.795484303
DOCK5SIN3A0.745537303
DOCK5ATG100.745033303
DOCK5HNRNPA10.744884303
DOCK5NGF0.741174303
DOCK5SMARCD10.739052303
DOCK5TCF7L20.736173303
DOCK5HHLA10.736056303
DOCK5ELOVL50.734907404
DOCK5PWWP2A0.72253303
DOCK5PDPR0.720606403
DOCK5TGFBR10.716993504
DOCK5TCF7L10.714439303
DOCK5XPNPEP10.710051303
DOCK5KIAA0895L0.706441303
DOCK5CPT1A0.704357303
DOCK5CBL0.697492303
DOCK5TOP3A0.696709403

For details and further investigation, click here