| Full name: SIX homeobox 4 | Alias Symbol: AREC3 | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 51804 | HGNC ID: HGNC:10890 | Ensembl Gene: ENSG00000100625 | OMIM ID: 606342 |
| Drug and gene relationship at DGIdb | |||
Expression of SIX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIX4 | 51804 | 229796_at | 1.8815 | 0.0140 | |
| GSE26886 | SIX4 | 51804 | 229796_at | 3.9269 | 0.0000 | |
| GSE45670 | SIX4 | 51804 | 229796_at | 1.6648 | 0.0057 | |
| GSE53622 | SIX4 | 51804 | 129378 | 3.5759 | 0.0000 | |
| GSE53624 | SIX4 | 51804 | 129378 | 3.6720 | 0.0000 | |
| GSE63941 | SIX4 | 51804 | 229796_at | 0.5389 | 0.3967 | |
| GSE77861 | SIX4 | 51804 | 229796_at | 1.0333 | 0.0148 | |
| GSE97050 | SIX4 | 51804 | A_32_P204205 | 1.1364 | 0.0620 | |
| SRP007169 | SIX4 | 51804 | RNAseq | 5.7546 | 0.0000 | |
| SRP008496 | SIX4 | 51804 | RNAseq | 7.6913 | 0.0000 | |
| SRP064894 | SIX4 | 51804 | RNAseq | 2.8992 | 0.0000 | |
| SRP133303 | SIX4 | 51804 | RNAseq | 2.9998 | 0.0000 | |
| SRP159526 | SIX4 | 51804 | RNAseq | 4.7588 | 0.0000 | |
| SRP193095 | SIX4 | 51804 | RNAseq | 2.9834 | 0.0000 | |
| SRP219564 | SIX4 | 51804 | RNAseq | 3.3029 | 0.0000 | |
| TCGA | SIX4 | 51804 | RNAseq | 0.5087 | 0.0082 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by SIX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIX4 | 51804 | 9 | 3 | 18 | |
| GSE20123 | SIX4 | 51804 | 8 | 3 | 19 | |
| GSE43470 | SIX4 | 51804 | 8 | 2 | 33 | |
| GSE46452 | SIX4 | 51804 | 16 | 3 | 40 | |
| GSE47630 | SIX4 | 51804 | 11 | 9 | 20 | |
| GSE54993 | SIX4 | 51804 | 3 | 9 | 58 | |
| GSE54994 | SIX4 | 51804 | 19 | 4 | 30 | |
| GSE60625 | SIX4 | 51804 | 0 | 2 | 9 | |
| GSE74703 | SIX4 | 51804 | 7 | 2 | 27 | |
| GSE74704 | SIX4 | 51804 | 4 | 2 | 14 | |
| TCGA | SIX4 | 51804 | 32 | 14 | 50 |
Total number of gains: 117; Total number of losses: 53; Total Number of normals: 318.
Somatic mutations of SIX4:
Generating mutation plots.
Highly correlated genes for SIX4:
Showing top 20/2182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIX4 | DNMT1 | 0.828088 | 7 | 0 | 7 |
| SIX4 | TCF3 | 0.809195 | 7 | 0 | 7 |
| SIX4 | NEO1 | 0.8066 | 3 | 0 | 3 |
| SIX4 | CDCA2 | 0.803946 | 5 | 0 | 5 |
| SIX4 | PYCR2 | 0.803454 | 3 | 0 | 3 |
| SIX4 | MCM7 | 0.80076 | 6 | 0 | 6 |
| SIX4 | PLXNA1 | 0.796442 | 7 | 0 | 7 |
| SIX4 | UBE2T | 0.795017 | 7 | 0 | 7 |
| SIX4 | HMGB3 | 0.784536 | 7 | 0 | 7 |
| SIX4 | TMEM184B | 0.781749 | 7 | 0 | 7 |
| SIX4 | U2SURP | 0.779835 | 5 | 0 | 5 |
| SIX4 | IMP4 | 0.776599 | 7 | 0 | 7 |
| SIX4 | MTERF3 | 0.773151 | 4 | 0 | 4 |
| SIX4 | MET | 0.772974 | 6 | 0 | 6 |
| SIX4 | SNRPE | 0.77269 | 7 | 0 | 7 |
| SIX4 | NAP1L1 | 0.76967 | 3 | 0 | 3 |
| SIX4 | RHPN2 | 0.768942 | 4 | 0 | 4 |
| SIX4 | KDM1A | 0.768884 | 6 | 0 | 5 |
| SIX4 | BRIX1 | 0.764968 | 7 | 0 | 7 |
| SIX4 | SMYD5 | 0.764927 | 6 | 0 | 6 |
For details and further investigation, click here
