| Full name: zinc finger protein 451 | Alias Symbol: KIAA0576|COASTER|dJ417I1.1|KIAA1702 | ||
| Type: protein-coding gene | Cytoband: 6p12.1 | ||
| Entrez ID: 26036 | HGNC ID: HGNC:21091 | Ensembl Gene: ENSG00000112200 | OMIM ID: 615708 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ZNF451:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZNF451 | 26036 | 1556060_a_at | 0.8913 | 0.1310 | |
| GSE20347 | ZNF451 | 26036 | 215012_at | 0.1049 | 0.6095 | |
| GSE23400 | ZNF451 | 26036 | 215012_at | 0.0755 | 0.2480 | |
| GSE26886 | ZNF451 | 26036 | 212557_at | -0.0489 | 0.8340 | |
| GSE29001 | ZNF451 | 26036 | 215012_at | -0.0052 | 0.9878 | |
| GSE38129 | ZNF451 | 26036 | 212557_at | 0.0476 | 0.6426 | |
| GSE45670 | ZNF451 | 26036 | 212557_at | -0.3037 | 0.0277 | |
| GSE53622 | ZNF451 | 26036 | 100077 | 0.4623 | 0.0000 | |
| GSE53624 | ZNF451 | 26036 | 120975 | 0.8345 | 0.0000 | |
| GSE63941 | ZNF451 | 26036 | 1556060_a_at | 0.1506 | 0.8120 | |
| GSE77861 | ZNF451 | 26036 | 1556060_a_at | 1.2604 | 0.0259 | |
| GSE97050 | ZNF451 | 26036 | A_33_P3257528 | 0.1540 | 0.5150 | |
| SRP007169 | ZNF451 | 26036 | RNAseq | 0.8381 | 0.0385 | |
| SRP008496 | ZNF451 | 26036 | RNAseq | 0.8554 | 0.0000 | |
| SRP064894 | ZNF451 | 26036 | RNAseq | 0.2151 | 0.2901 | |
| SRP133303 | ZNF451 | 26036 | RNAseq | 0.3187 | 0.0203 | |
| SRP159526 | ZNF451 | 26036 | RNAseq | -0.0574 | 0.7270 | |
| SRP193095 | ZNF451 | 26036 | RNAseq | 0.1048 | 0.1652 | |
| SRP219564 | ZNF451 | 26036 | RNAseq | 0.3066 | 0.2698 | |
| TCGA | ZNF451 | 26036 | RNAseq | -0.1158 | 0.0222 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ZNF451 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZNF451:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZNF451 | 26036 | 8 | 2 | 20 | |
| GSE20123 | ZNF451 | 26036 | 8 | 2 | 20 | |
| GSE43470 | ZNF451 | 26036 | 4 | 0 | 39 | |
| GSE46452 | ZNF451 | 26036 | 2 | 10 | 47 | |
| GSE47630 | ZNF451 | 26036 | 7 | 5 | 28 | |
| GSE54993 | ZNF451 | 26036 | 3 | 2 | 65 | |
| GSE54994 | ZNF451 | 26036 | 9 | 4 | 40 | |
| GSE60625 | ZNF451 | 26036 | 0 | 1 | 10 | |
| GSE74703 | ZNF451 | 26036 | 4 | 0 | 32 | |
| GSE74704 | ZNF451 | 26036 | 4 | 1 | 15 | |
| TCGA | ZNF451 | 26036 | 23 | 10 | 63 |
Total number of gains: 72; Total number of losses: 37; Total Number of normals: 379.
Somatic mutations of ZNF451:
Generating mutation plots.
Highly correlated genes for ZNF451:
Showing top 20/728 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZNF451 | RAD21 | 0.838809 | 3 | 0 | 3 |
| ZNF451 | U2AF2 | 0.8232 | 4 | 0 | 4 |
| ZNF451 | CCDC14 | 0.821273 | 4 | 0 | 4 |
| ZNF451 | WDR81 | 0.820657 | 3 | 0 | 3 |
| ZNF451 | SF3A2 | 0.807068 | 3 | 0 | 3 |
| ZNF451 | TMTC4 | 0.806067 | 3 | 0 | 3 |
| ZNF451 | NUFIP2 | 0.800023 | 3 | 0 | 3 |
| ZNF451 | KBTBD6 | 0.797438 | 3 | 0 | 3 |
| ZNF451 | KHSRP | 0.79666 | 3 | 0 | 3 |
| ZNF451 | ZNF787 | 0.796066 | 3 | 0 | 3 |
| ZNF451 | U2SURP | 0.79553 | 3 | 0 | 3 |
| ZNF451 | FZD6 | 0.786482 | 3 | 0 | 3 |
| ZNF451 | CRTC2 | 0.783369 | 4 | 0 | 4 |
| ZNF451 | UBXN7 | 0.771982 | 4 | 0 | 4 |
| ZNF451 | TERF1 | 0.769491 | 4 | 0 | 4 |
| ZNF451 | ZNF791 | 0.764751 | 3 | 0 | 3 |
| ZNF451 | SLC26A11 | 0.764188 | 3 | 0 | 3 |
| ZNF451 | SLC39A10 | 0.762031 | 4 | 0 | 4 |
| ZNF451 | ZXDC | 0.760306 | 3 | 0 | 3 |
| ZNF451 | DPY19L4 | 0.759403 | 4 | 0 | 4 |
For details and further investigation, click here
