| Full name: arachidonate 15-lipoxygenase | Alias Symbol: 15-LOX-1 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 246 | HGNC ID: HGNC:433 | Ensembl Gene: ENSG00000161905 | OMIM ID: 152392 |
| Drug and gene relationship at DGIdb | |||
Expression of ALOX15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALOX15 | 246 | 207328_at | 0.0605 | 0.8196 | |
| GSE20347 | ALOX15 | 246 | 207328_at | 0.0814 | 0.2269 | |
| GSE23400 | ALOX15 | 246 | 207328_at | 0.0075 | 0.7620 | |
| GSE26886 | ALOX15 | 246 | 207328_at | 0.1065 | 0.3418 | |
| GSE29001 | ALOX15 | 246 | 207328_at | -0.1166 | 0.4739 | |
| GSE38129 | ALOX15 | 246 | 207328_at | 0.0820 | 0.4167 | |
| GSE45670 | ALOX15 | 246 | 207328_at | 0.1418 | 0.6076 | |
| GSE53622 | ALOX15 | 246 | 30602 | 0.7298 | 0.0063 | |
| GSE53624 | ALOX15 | 246 | 30602 | 0.7076 | 0.0000 | |
| GSE63941 | ALOX15 | 246 | 207328_at | 0.4654 | 0.1883 | |
| GSE77861 | ALOX15 | 246 | 207328_at | -0.0277 | 0.8458 | |
| GSE97050 | ALOX15 | 246 | A_33_P3361348 | 0.1816 | 0.7959 | |
| SRP064894 | ALOX15 | 246 | RNAseq | 0.5251 | 0.0691 | |
| SRP133303 | ALOX15 | 246 | RNAseq | 1.5588 | 0.0250 | |
| TCGA | ALOX15 | 246 | RNAseq | 3.2111 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ALOX15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALOX15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALOX15 | 246 | 5 | 2 | 23 | |
| GSE20123 | ALOX15 | 246 | 5 | 3 | 22 | |
| GSE43470 | ALOX15 | 246 | 1 | 6 | 36 | |
| GSE46452 | ALOX15 | 246 | 34 | 1 | 24 | |
| GSE47630 | ALOX15 | 246 | 7 | 1 | 32 | |
| GSE54993 | ALOX15 | 246 | 4 | 3 | 63 | |
| GSE54994 | ALOX15 | 246 | 5 | 9 | 39 | |
| GSE60625 | ALOX15 | 246 | 4 | 0 | 7 | |
| GSE74703 | ALOX15 | 246 | 1 | 3 | 32 | |
| GSE74704 | ALOX15 | 246 | 3 | 1 | 16 | |
| TCGA | ALOX15 | 246 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 50; Total Number of normals: 351.
Somatic mutations of ALOX15:
Generating mutation plots.
Highly correlated genes for ALOX15:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALOX15 | ACSM5 | 0.70807 | 3 | 0 | 3 |
| ALOX15 | ZFPM1 | 0.707741 | 3 | 0 | 3 |
| ALOX15 | SLC2A11 | 0.702526 | 3 | 0 | 3 |
| ALOX15 | TRPM3 | 0.67851 | 3 | 0 | 3 |
| ALOX15 | PGC | 0.672782 | 3 | 0 | 3 |
| ALOX15 | LIME1 | 0.662733 | 4 | 0 | 3 |
| ALOX15 | LILRA3 | 0.659419 | 3 | 0 | 3 |
| ALOX15 | IL21 | 0.657617 | 3 | 0 | 3 |
| ALOX15 | OPRD1 | 0.654385 | 3 | 0 | 3 |
| ALOX15 | IGSF9 | 0.654125 | 3 | 0 | 3 |
| ALOX15 | PRR18 | 0.651289 | 3 | 0 | 3 |
| ALOX15 | LCT | 0.651228 | 3 | 0 | 3 |
| ALOX15 | TMPRSS6 | 0.649242 | 3 | 0 | 3 |
| ALOX15 | TSKS | 0.648282 | 3 | 0 | 3 |
| ALOX15 | FAM178B | 0.64663 | 3 | 0 | 3 |
| ALOX15 | PCSK1N | 0.646317 | 4 | 0 | 3 |
| ALOX15 | MEPE | 0.645481 | 4 | 0 | 3 |
| ALOX15 | NTN3 | 0.64254 | 3 | 0 | 3 |
| ALOX15 | LTK | 0.64098 | 3 | 0 | 3 |
| ALOX15 | SLC22A31 | 0.640807 | 3 | 0 | 3 |
For details and further investigation, click here
