| Full name: nitric oxide synthase 2 | Alias Symbol: iNOS|NOS|HEP-NOS | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 4843 | HGNC ID: HGNC:7873 | Ensembl Gene: ENSG00000007171 | OMIM ID: 163730 |
| Drug and gene relationship at DGIdb | |||
NOS2 involved pathways:
Expression of NOS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOS2 | 4843 | 210037_s_at | 0.1139 | 0.7555 | |
| GSE20347 | NOS2 | 4843 | 210037_s_at | -0.0641 | 0.2447 | |
| GSE23400 | NOS2 | 4843 | 210037_s_at | -0.1388 | 0.0000 | |
| GSE26886 | NOS2 | 4843 | 210037_s_at | -0.0957 | 0.3986 | |
| GSE29001 | NOS2 | 4843 | 210037_s_at | -0.0225 | 0.8931 | |
| GSE38129 | NOS2 | 4843 | 210037_s_at | -0.0108 | 0.8713 | |
| GSE45670 | NOS2 | 4843 | 210037_s_at | 0.1245 | 0.2518 | |
| GSE53622 | NOS2 | 4843 | 20248 | 1.1108 | 0.0000 | |
| GSE53624 | NOS2 | 4843 | 12046 | 1.8286 | 0.0000 | |
| GSE63941 | NOS2 | 4843 | 210037_s_at | -0.0266 | 0.8521 | |
| GSE77861 | NOS2 | 4843 | 210037_s_at | -0.0357 | 0.8193 | |
| SRP159526 | NOS2 | 4843 | RNAseq | 4.6680 | 0.0000 | |
| SRP219564 | NOS2 | 4843 | RNAseq | 0.2013 | 0.7975 | |
| TCGA | NOS2 | 4843 | RNAseq | 1.0641 | 0.0237 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by NOS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOS2 | 4843 | 9 | 1 | 20 | |
| GSE20123 | NOS2 | 4843 | 9 | 1 | 20 | |
| GSE43470 | NOS2 | 4843 | 0 | 1 | 42 | |
| GSE46452 | NOS2 | 4843 | 33 | 1 | 25 | |
| GSE47630 | NOS2 | 4843 | 7 | 1 | 32 | |
| GSE54993 | NOS2 | 4843 | 2 | 3 | 65 | |
| GSE54994 | NOS2 | 4843 | 7 | 6 | 40 | |
| GSE60625 | NOS2 | 4843 | 4 | 0 | 7 | |
| GSE74703 | NOS2 | 4843 | 0 | 1 | 35 | |
| GSE74704 | NOS2 | 4843 | 7 | 1 | 12 | |
| TCGA | NOS2 | 4843 | 21 | 10 | 65 |
Total number of gains: 99; Total number of losses: 26; Total Number of normals: 363.
Somatic mutations of NOS2:
Generating mutation plots.
Highly correlated genes for NOS2:
Showing top 20/323 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOS2 | DPF3 | 0.7472 | 3 | 0 | 3 |
| NOS2 | CDH15 | 0.741647 | 3 | 0 | 3 |
| NOS2 | NCAN | 0.706923 | 3 | 0 | 3 |
| NOS2 | CXCR1 | 0.70303 | 4 | 0 | 3 |
| NOS2 | BIRC7 | 0.694749 | 3 | 0 | 3 |
| NOS2 | SLC9A5 | 0.678885 | 3 | 0 | 3 |
| NOS2 | REM1 | 0.677673 | 4 | 0 | 4 |
| NOS2 | FAM71F1 | 0.67284 | 3 | 0 | 3 |
| NOS2 | GYPA | 0.671451 | 3 | 0 | 3 |
| NOS2 | GRIP2 | 0.663758 | 4 | 0 | 4 |
| NOS2 | OVGP1 | 0.658847 | 4 | 0 | 4 |
| NOS2 | CPS1-IT1 | 0.657172 | 4 | 0 | 3 |
| NOS2 | CCL24 | 0.655764 | 3 | 0 | 3 |
| NOS2 | TMPRSS6 | 0.655587 | 3 | 0 | 3 |
| NOS2 | NR5A1 | 0.65348 | 4 | 0 | 3 |
| NOS2 | RUNDC3A | 0.652721 | 3 | 0 | 3 |
| NOS2 | NKX2-5 | 0.649526 | 4 | 0 | 3 |
| NOS2 | IFNA14 | 0.647056 | 3 | 0 | 3 |
| NOS2 | CRTC1 | 0.645926 | 4 | 0 | 4 |
| NOS2 | CHRNA4 | 0.645043 | 3 | 0 | 3 |
For details and further investigation, click here
